This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Dolutegravir was approved as antiretroviral medication by FDA on 12/08/2013 to treat HIV infection.

Mechanism of Action of undefined

Dolutegravir Tablet is an antiretroviral medication belonging to the category of HIV integrase inhibitors. It works by increasing the number of CD4 T cells and stimulates the immune system to fight against infections. It helps reduce the viral load of HIV in the blood and lowers the severity of HIV infection.

Uses of undefined

Dolutegravir has been developed to treat Human Immunodeficiency Virus (HIV-1) in adults and children infected with HIV 1.

undefined Drug administaration and Dosage available

Dolutegravir is available as film coated tablets and oral suspension. The tablets are available in the dose 50mg. The usual recommended dosage of Dolutegravir is one tablet everyday with or without food.

Warnings, Precautions and Side Effects of undefined


Do not take this medication if you have experienced hypersensitivity reactions to Dolutegravir or its ingredients. During treatment with Dolutegravir Tablet, your doctor will test you for hepatitis B virus and may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with diabetes, hypertension, high blood cholesterol, pancreatitis, bone disease, fractures, liver or kidney problems. Tell your healthcare provider and discontinue medication if you experience unusual blisters, breathing trouble, swelling of face, mouth, lips or tongue, dark urine or extreme tiredness.


Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment as Dolutegravir is not recommended during early pregnancy. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Dolutegravir Tablet are sleeping trouble, tiredness and headache. Some serious adverse reactions include bone loss, worsening of Hepatitis B and C infection, kidney injury, immune reconstitution syndrome, lactic acidosis, and liver problems. If you experience any allergic reactions after taking this tablet, report to your doctor immediately.

Word Of Advice

Dolutegravir can make you feel tired. Hence, you should avoid driving or handling machines during this treatment.

Frequently Asked Question


  1. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
  2. GlaxoSmithKline, U.S. Food and Drug Administration, [Revised on Oct 2022] [Accessed on 13th Oct 2022],
  3. Kandel CE, Walmsley SL, Dolutegravir - a review of the pharmacology, efficacy, and safety in the treatment of HIV, Drug Des Devel Ther., 2015, 7(9), 3547-55,   


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.