This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate is a complete regimen consisting of antiviral medications, which was approved for its medical use in 2018.


Mechanism of Action of undefined

Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate Tablet is a combination of non-nucleoside reverse transcriptase inhibitor and nucleoside reverse transcriptase inhibitors. It works by increasing the number of CD4 T cells and stimulates the immune system to fight against infections. Thereby, it reduces the viral load of HIV in the blood and decreases the severity of HIV infection.

Uses of undefined

Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate is indicated as a complete regimen to treat human immunodeficiency virus infection in adults and paediatric patients weighing at least 40kg.

undefined Drug administaration and Dosage available

Efavirenz, Lamivudine and Tenofovir disoproxil fumarate is available as film coated tablets consisting of 600mg of Efavirenz, 300mg of Lamivudine and 300mg of Tenofovir disoproxil fumarate. The usual recommended dosage of this combination regimen is one tablet every day, preferably at bedtime.

Warnings, Precautions and Side Effects of undefined


Do not take this medication if you have experienced hypersensitivity reactions to Efavirenz, lamivudine or Tenofovir disoproxil fumarate. Patients who are diagnosed with pancreatitis or at risk of pancreatitis should take this combination medicine with caution. During the Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate Tablet treatment, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have had a history of heart failure, seizures, pancreatitis, bone disease, fractures, liver or kidney problems. Seek immediate medical attention from a nearby hospital if you experience any psychiatric symptoms like depression or suicidal thoughts during this treatment.


Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. Avoid getting pregnant during and 12 weeks after the last dose of Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate. If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment as this combination regimen is not recommended during early pregnancy. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate Tablet are impaired concentration, abnormal dreams, headache, nausea, muscle pain, tiredness, diarrhoea, rash, dizziness, insomnia, pain, depression, asthenia and cough. Some serious adverse reactions include bone loss, worsening of Hepatitis B, acute kidney injury, immune reconstitution syndrome, etc. If you experience any allergic reactions after taking this tablet, report to your doctor immediately.

Word Of Advice

Efavirenz, Lamivudine and Tenofovir disoproxil Fumarate can make you feel tired and dizzy. Hence, you should avoid driving or handling machines during this treatment. 

Frequently Asked Question


  1. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
  2. Mylan Laboratories Limited., U.S. Food and Drug Administration, [Revised on Oct 2019] [Accessed on 21st Oct 2022],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.