This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Esomeprazole and Domperidone is a combination medication developed by the U.S. Food And Drug Administration and initially approved for treating gastroesophageal reflux disease.

Mechanism of Action of undefined

Esomeprazole works by irreversibly binding to the proton pump and inhibiting its function. By doing so, it blocks the final step of acid production. Specifically, this drug inhibits the enzyme's ability to transport hydrogen ions (protons) into the stomach, thereby reducing gastric acid secretion. Domperidone enhances the movement and contractions of the stomach and intestines. It helps to improve gastrointestinal motility and facilitates the food to pass through the digestive part.

Uses of undefined

Esomeprazole and Domperidone treat conditions such as gastroesophageal reflux disease (in which the stomach acid and contents flow back into the esophagus), peptic ulcers (a sore or erosion that forms on the stomach lining), and nausea and vomiting.

undefined Drug administaration and Dosage available

Take the Esomeprazole and Domperidone Tablet as your physician advises. Usually, the tablets will be taken with a glass of water. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Warnings, Precautions and Side Effects of undefined


This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Esomeprazole, Domperidone may worsen urinary retention (inability to empty the bladder). It should be used with caution in these individuals, and discontinuation of treatment should be considered if urinary retention occurs. Inform your physician of any kidney or liver disease. Your physician may prescribe you a low dose and perform regular blood tests.


It is generally recommended to avoid using Esomeprazole, Domperidone during pregnancy unless it is necessary. Taking this drug while breastfeeding is unsafe because it may affect the child. Do not breastfeed while taking this medicine. This tablet does contain lactose, and if you have been diagnosed with a rare hereditary problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency, it is advised not to use this medication.

Side Effects

The side effects known to occur commonly during the treatment with Esomeprazole, Domperidone are headache, stomach pain, accumulation of gas, nausea, vomiting, constipation, diarrhea and benign polyps in the stomach (masses of cells form in the stomach lining).

Word Of Advice

Take the Esomeprazole and Domperidone tablets, exactly as your physician prescribes. Do not change the dose or stop taking the medication without consulting your doctor first. This drug is usually taken at least one hour before meals. Follow the general instructions given by your doctor regarding the timing and dosing of the medication. While taking this medicine, making certain dietary modifications to support your treatment may be helpful. Avoid foods and beverages that trigger your symptoms, such as spicy or acidic foods, caffeine, and alcohol. Eat smaller meals and avoid eating close to bedtime. Consider elevating the head of your bed to help reduce nighttime acid reflux.

Frequently Asked Question


  1. Mylan, Electronic medicines compendium (EMC), [ Revised on Jan 2018] [ Accessed on 07 August 2023],
  2. Ciplamed; [ Accessed on 07 August 2023],
  3. KD Tripathi, Essentials of Medical Pharmacology, Drugs for Peptic ulcer and Gastrointestinal oesophageal reflux disease, 7th edition, 2013, 653.
  4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Pharmacotherapy of Acidity, ulcers, and Reflux disease, 12th edition, 2011, 1318.


The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.