This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Flucloxacillin belongs to the cause of Beta-lactam antibiotics.

Mechanism of Action of undefined

Flucloxacillin exerts its therapeutic effect through inhibition of bacterial cell wall synthesis. As a beta-lactam antibiotic, it interferes with the activity of enzymes known as penicillin-binding proteins (PBPs) that are crucial for cross-linking bacterial cell wall components. Disrupting this process weakens the integrity of the bacterial cell wall, leading to osmotic instability and, ultimately, bacterial cell death. This mechanism primarily targets bacteria like Staphylococcus aureus, rendering them susceptible to the drug's action.

Uses of undefined

Flucloxacillin is used to treat various bacterial infections caused by susceptible organisms. It finds application in skin and soft tissue infections such as boils, cellulitis, and impetigo, as well as bone and joint infections like osteomyelitis and septic arthritis. It is also used for certain respiratory tract infections caused by susceptible bacteria. Its effectiveness against staphylococcus species, including Staphylococcus aureus, makes it valuable in treating staphylococcal infections. Additionally, it might be used for prevention against bacterial endocarditis during certain dental or surgical procedures in individuals with specific heart conditions. 

undefined Drug administaration and Dosage available

Flucloxacillin is available in various forms, including oral capsules, oral suspensions, and injectable forms for intravenous use. The route of administration depends on the type and severity of the infection being treated. 

Warnings, Precautions and Side Effects of undefined


Flucloxacillin can cause severe allergic reactions, including anaphylaxis. Although rare, serious skin reactions like Stevens-Johnson syndrome can occur with flucloxacillin use. It may lead to liver problems, such as jaundice and hepatic impairment. This medication can lead to Clostridium difficile-associated diarrhea (CDAD), potentially causing severe gastrointestinal issues.


If severe allergic reactions occur, require immediate medical attention. If you have a history of liver problems, close monitoring is necessary during flucloxacillin use. Individuals with kidney issues may require dosage adjustments to ensure proper medication clearance. Complete the entire prescribed course of this medication, even if symptoms improve earlier, to prevent antibiotic resistance.

Side Effects

Flucloxacillin use can lead to a range of side effects, with common ones like gastrointestinal disturbances like nausea, vomiting, diarrhea, skin rash, and yeast infections due to alterations in normal bacterial balance. Mild digestive upset, changes in taste, and pain or inflammation at injection sites (in the case of intravenous administration) may occur. Notably, serious side effects are infrequent but can include severe allergic reactions, such as difficulty breathing and swelling, and potentially life-threatening skin reactions like Stevens-Johnson syndrome. Liver dysfunction might manifest as jaundice or abdominal discomfort.

Word Of Advice

Inform your healthcare provider about any allergies, especially to penicillin antibiotics, and previous adverse reactions to antibiotics before starting Flucloxacillin. Individuals with liver conditions or renal impairment need close monitoring, as its metabolism occurs in the liver and excretion in the kidneys. Complete the full prescribed course to prevent antibiotic resistance and inform your doctor if you have underlying medical conditions, are pregnant, breastfeeding, or taking other medications. Be cautious of potential interactions, and immediately report any severe side effects, such as severe skin reactions or allergic responses. If you experience unusual symptoms, consult your healthcare provider and adhere to storage instructions, keeping the medication away from children and pets. Always consult your healthcare provider for advice based on your specific medical situation.

Frequently Asked Question


  1. Mastroviti S, Cassarino G. La Flucloxacillina,. G Bacteriol Virol Immunol.[Published on July 1975] [Accessed on 29th Aug 2023],
  2. Aurobindo Pharma - Milpharm Ltd., Electronic Medicines Compendium (EMC), [Revised on 29th August 2023] [Accessed on 29th Aug 2023],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.