This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA approved Fluticasone and Salmeterol on August 24, 2000, to treat asthma and chronic obstructive pulmonary disease (COPD). The combination helps reduce inflammation and improve airflow in the lungs.

Mechanism of Action of undefined

The combination of Fluticasone and Salmeterol works by reducing airway inflammation (Fluticasone) and relaxing the smooth muscles in the airways (Salmeterol). This dual action helps improve breathing and manage symptoms of asthma and COPD.

Uses of undefined

The combination of Fluticasone and Salmeterol is used to manage asthma and chronic obstructive pulmonary disease (COPD). Fluticasone reduces inflammation in the airways, while Salmeterol helps relax the muscles around the airways, making breathing easier. This combination is typically prescribed for patients whose symptoms are not adequately controlled by other medications. It helps prevent asthma attacks and manage COPD symptoms, such as wheezing and shortness of breath.

undefined Drug administaration and Dosage available

The Fluticasone and Salmeterol combination is administered via an inhaler or dry powder inhaler, typically twice daily—once in the morning and once in the evening. For asthma, two inhalations per dose are usually prescribed, while for COPD, one inhalation per dose is common. It's important to follow the prescribed dosage and not exceed it. After each use, patients should rinse their mouth to reduce the risk of side effects like oral thrush. Always consult a healthcare professional for proper usage instructions.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Not for Acute Asthma: Not suitable for acute asthma attacks. Use a fast-acting bronchodilator in emergencies.
  • Worsening Asthma: Increased use of short-acting bronchodilators may signal deteriorating asthma control; consult a physician.
  • Do Not Stop Abruptly: Discontinuation can cause exacerbations, particularly in asthma. Dose reduction should be supervised by a doctor.
  • Caution in Specific Conditions: Use with caution in patients with pulmonary tuberculosis, severe cardiovascular issues, diabetes, or thyroid disorders.
  • Systemic Effects: Long-term use can lead to Cushing’s syndrome, adrenal suppression, and growth retardation in children.
  • Adrenal Crisis Risk: High doses, especially in children, may increase the risk of adrenal crisis during stress or surgery.
  • Paradoxical Bronchospasm: Rarely, paradoxical bronchospasm may occur; discontinue if this happens.
  • Drug Interactions: Avoid combining with Ritonavir or potent CYP3A inhibitors due to increased risk of systemic side effects.
  • Lactose Content: Contains lactose, which may affect highly lactose-intolerant individuals.

Precautions

Fluticasone and Salmeterol should be used cautiously in patients with pulmonary tuberculosis, severe cardiovascular disorders, diabetes, or thyroid issues. Doctors should regularly monitor patients, especially children, for potential growth effects and adrenal suppression. Patients must not stop the medication abruptly; any dose reductions should be managed under medical supervision. They should also avoid using it for acute asthma attacks and ensure they have a fast-acting bronchodilator on hand.

Side Effects

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Fluticasone and Salmeterol:

  • Candidiasis (thrush) of the mouth and throat
  • Headache
  • Tremor
  • Throat irritation
  • Hoarseness/dysphonia
  • Palpitations
  • Tachycardia (fast heart rate)
  • Muscle cramps
  • Arthralgia (joint pain)

Serious side effects of Fluticasone and Salmeterol:

  • Hypersensitivity reactions (e.g., skin reactions, angioedema, respiratory symptoms, anaphylaxis)
  • Cushing's syndrome and Cushingoid features
  • Adrenal suppression
  • Growth retardation in children and adolescents
  • Decreased bone mineral density
  • Cataracts
  • Glaucoma
  • Hyperglycaemia (high blood sugar)
  • Paradoxical bronchospasm (worsening of breathing difficulty)

Word Of Advice

Always follow your doctor's guidance when using Fluticasone and Salmeterol. Make sure to regularly monitor your asthma or COPD symptoms and discuss any changes with your healthcare provider. Never stop the medication suddenly; work with your doctor to adjust the dose safely. Keep a fast-acting bronchodilator available for acute asthma attacks. If you have any underlying health conditions, inform your doctor to ensure proper management while on this treatment.

Frequently Asked Question

References

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021077s061lbl.pdf

2. https://www.ema.europa.eu/en/documents/referral/seretide-diskus-article-6-13-referral-annex-i-ii-iii_en.pdf

3. Adams BS, Nguyen H. Salmeterol. [Updated 2023 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557453/

4. Remien K, Patel P, Bowman A. Fluticasone. [Updated 2024 May 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542161/

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.