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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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Quick Summary
GOSERELIN ACETATE
Last updated on 31 Mar 2026 | 09:31 AM (IST)
GOSERELIN ACETATE
Background and Date of approval GOSERELIN ACETATE
Goserelin Acetate is a gonadotropin-releasing hormone agonist. Goserelin Acetate 3.6mg implant was approved in 1989 whereas Goserelin Acetate 10.8mg was approved in 1996.
Uses of GOSERELIN ACETATE
Goserelin Acetate Injection is an anticancer medication indicated for the palliative treatment of Advanced prostate cancer and breast cancer. It is also indicated as an endometrial thinning agent in uterine bleeding and for the management of endometriosis.
How is GOSERELIN ACETATE administered?
Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg. It is administered through subcutaneous route.
Goserelin Acetate 10.8mg Injection should be administered every 12 weeks below the navel and Goserelin Acetate 3.6mg Injection should be administered every 28 days. For patients with endometriosis, Goserelin Acetate 3.6mg Injection is indicated every 6 months.
Side Effects of GOSERELIN ACETATE
The common side effects that are likely to occur while you are on the treatment with Goserelin Acetate Injection are hot flashes, decreased erection in men, headache, sweating, acne, sexual dysfunction, depression, decreased libido, vaginitis in women, peripheral edema. Lower urinary tract infection is a common side effect of Goserelin Acetate 10.8mg Injection. If you experience any allergic reactions after taking this medicine, report to your healthcare provider immediately.
Warnings
Goserelin Acetate Injection is not recommended for people who are hypersensitive to Goserelin Acetate or other GnRH agonists. Your healthcare provider will monitor your serum testosterone levels, blood glucose levels, serum calcium and cardiac function. Regular monitoring will prevent the risk of spinal cord compression and urinary tract obstruction. Tell your healthcare provider if you have been diagnosed with heart problems or diabetes.
Precautions
Goserelin Acetate can impair fertility in men and women of reproductive age. Goserelin Acetate is not recommended for use during pregnancy as it has the tendency to cause fetal harm. Hence, it is advisable to tell your physician before starting this treatment if you are pregnant or planning to get pregnant. It is not known if Goserelin Acetate passes into the breast milk. If you are a breastfeeding mother, your health care provider will suggest whether to discontinue breastfeeding or discontinue this treatment based on your condition.
Word of Advice
Goserelin Acetate can cause urinary tract infections. Hence, it is advised to consume plenty of water during the treatment and reach out to your healthcare provider if you experience any discomfort
Frequently Asked Questions
Q1.
What should you know before taking Goserelin Acetate?
It is important to be aware that Goserelin Acetate may cause infertility, urinary tract infection, high blood sugar, tumor flare and heart problems.
Q2.
Is Goserelin Acetate Injection safe for women?
Goserelin Acetate 10.8mg Injection is not recommended for women due to its tendency to reduce estrogen levels significantly. For women requiring Goserelin Acetate, your healthcare provider might prescribe the lower dose i.e., Goserelin Acetate 3.6mg Injection.
Q3.
How to store Goserelin Acetate Injection?
Store Goserelin Acetate Injection at room temperature below 25°C.
Q4.
How long does it take for Goserelin Acetate Injection to work in women?
It typically takes around three weeks after the first injection to lower estrogen levels in women.
Q5.
How is Goserelin Acetate Injection administered?
Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg. It is administered through the subcutaneous route. The accurate dose and duration of administration will be decided by your physician according to your medical condition.
Q6.
Who should not take Goserelin Acetate Injection?
Goserelin Acetate is not recommended for pregnant women and patients who have experienced allergic reaction to Goserelin Acetate or other gonadotropin releasing hormone agonists.
Q7.
Is it safe to consume alcohol or smoke during Goserelin Acetate treatment?
Avoid smoking cigarettes and smoking alcohol while on treatment with Goserelin Acetate as it increases your risk of bone loss, stroke and heart problems.
References
1. TerSera Therapeutics LLC., [Revised on Dec 2020] [Accessed on 28th Sep 2022], https://documents.tersera.com/zoladex-us/3.6mg_MagnumPI.pdf
2. TerSera Therapeutics LLC., [Revised on Dec 2020] [Accessed on 28th Sep 2022], https://documents.tersera.com/zoladex-us/10.8mg_MagnumPI.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Anterior Pituitary Hormones, 8th Edition, 2019, 257-266.
4. Claudine Isaacs, Anton Wellstein, and Anna T. Riegel, Hormones and Related Agents in the Therapy of Cancer, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1237-1247.
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.
