This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Goserelin Acetate is a gonadotropin-releasing hormone agonist. Goserelin Acetate 3.6mg implant was approved in 1989 whereas Goserelin Acetate 10.8mg was approved in 1996.

Mechanism of Action of undefined

Goserelin Acetate is a synthetic analogue of gonadotropin releasing hormone that binds to the gonadotropin receptors of pituitary gland. It lowers the androgen and testosterone levels in men and oestrogen levels in women. It is prescribed in combination with androgen antagonist like flutamide to prevent the initial flare up of tumor.

Uses of undefined

Goserelin Acetate Injection is an anticancer medication indicated for the palliative treatment of Advanced prostate cancer and breast cancer. It is also indicated as an endometrial thinning agent in uterine bleeding and for the management of endometriosis.

undefined Drug administaration and Dosage available

Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg.  It is administered through subcutaneous route. 

Goserelin Acetate 10.8mg Injection should be administered every 12 weeks below the navel and Goserelin Acetate 3.6mg Injection should be administered every 28 days. For patients with endometriosis, Goserelin Acetate 3.6mg Injection is indicated every 6 months.

Warnings, Precautions and Side Effects of undefined


Goserelin Acetate Injection is not recommended for people who are hypersensitive to Goserelin Acetate or other GnRH agonists. Your healthcare provider will monitor your serum testosterone levels, blood glucose levels, serum calcium and cardiac function. Regular monitoring will prevent the risk of spinal cord compression and urinary tract obstruction. Tell your healthcare provider if you have been diagnosed with heart problems or diabetes.


Goserelin Acetate can impair fertility in men and women of reproductive age. Goserelin Acetate is not recommended for use during pregnancy as it has the tendency to cause fetal harm. Hence, it is advisable to tell your physician before starting this treatment if you are pregnant or planning to get pregnant. It is not known if Goserelin Acetate passes into the breast milk. If you are a breastfeeding mother, your health care provider will suggest whether to discontinue breastfeeding or discontinue this treatment based on your condition.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Goserelin Acetate Injection are hot flashes, decreased erection in men, headache, sweating, acne, sexual dysfunction, depression, decreased libido, vaginitis in women, peripheral edema. Lower urinary tract infection is a common side effect of Goserelin Acetate 10.8mg Injection. If you experience any allergic reactions after taking this medicine, report to your healthcare provider immediately.

Word Of Advice

Goserelin Acetate can cause urinary tract infections. Hence, it is advised to consume plenty of water during the treatment and reach out to your healthcare provider if you experience any discomfort

Frequently Asked Question


1. TerSera Therapeutics LLC., [Revised on Dec 2020] [Accessed on 28th Sep 2022],

2. TerSera Therapeutics LLC., [Revised on Dec 2020] [Accessed on 28th Sep 2022],

3. KD Tripathi, Essentials of Medical Pharmacology, Anterior Pituitary Hormones, 8th Edition, 2019, 257-266.

4. Claudine Isaacs, Anton Wellstein, and Anna T. Riegel, Hormones and Related Agents in the Therapy of Cancer, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1237-1247.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.