Histamine Dihydrochloride + Human normal immunoglobulin + Sodium thiosulphate is a combination medicine approved for use to treat and prevent a number of allergic conditions, including generalized skin allergies, eczema, and allergic rhinitis. 

It is used to treat Eczema, urticaria, migraine headaches, premenstrual syndrome (PMS) and provides relief from respiratory distress and rhinitis. 

It is available in injection form of dose 1 ml administered subcutaneously containing the composition in ratio of human normal immunoglobulin 12 mg, histamine dihydrochloride 0.15 mcg, sodium thiosulphate 32mg. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. 

Histamine dihydrochloride + human normal immunoglobulin + sodium thiosulphate can cause side effects like any other medicine. Sometimes it may cause some serious side effects that include severe allergic reactions, muscle weakness or paralysis, severe pain or swelling at the injection site and even blood clots commonly, people may experience injection site reactions, fever, nausea and vomiting, diarrhea, dizziness and fatigue.

Avoid Histamine + Dihydrochloride + Human normal immunoglobulin + Sodium thiosulphate if allergic to any of its components. Consult your physician if you have an allergy or superinfection; these conditions should be addressed before beginning this injectable therapy. Because this injection is a thermolabile medication, it should only be used with a cool syringe. It needs to be applied subcutaneously.

 Due to limited data on its safety during pregnancy and breastfeeding, this medication is generally not recommended in these situations.  This medication is ineffective during an acute allergic attack, such as anaphylaxis. Discuss with your doctor if you have any underlying medical conditions like severe kidney or liver disease, as they might need special considerations when using it. It can be used safely in children under proper medical supervision.

Avoid receiving live vaccines while using Histamine + Dihydrochloride + Human normal immunoglobulin + Sodium thiosulphate or within a certain period after its administration. Immunoglobulin products might interfere with the effectiveness of live vaccines, so consult your healthcare provider about the appropriate timing for vaccinations. Inform your healthcare provider about any existing medical conditions you have, especially those related to kidney problems, blood clotting disorders, or a history of thrombosis (blood clots).  If you have concerns about infections, discuss them with your healthcare provider.  Inform your doctor about all the medications, supplements, or herbal products you are taking, as these might interact with this medication, affecting its efficacy or causing adverse reactions. Report any adverse reactions or unexpected symptoms experienced after receiving it to your healthcare provider promptly. 

1. Bharat Serums and Vaccines Limited, [Accessed on 28th Dec 2023], https://www.bharatserums.com/assets/pdf/products/Histoglob.pdf
2. Dr.Surya Mangadevi. Thota, Efficacy of Injection Histoglob in Treatment of Chronic Urticaria-A Prospective Study, IOSR Journal of Dental and Medical Sciences, 2019, 18(3), 57-62, https://www.iosrjournals.org/iosr-jdms/papers/Vol18-issue3/Series-8/L1803085762.pdf 
3. Bertram G. Katzung, Histamine, Serotonin & the Ergot Alkaloids, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 277-299.

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.