This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA-approved Hylan polymer A&B G-F 20 to treat people with knee osteoarthritis on August 1997. 

Mechanism of Action of undefined

Hylan polymer A&B G-F 20 works by enabling a process called viscosupplementation; in viscosupplementation, the cartilage cells are protected from physical and chemical damage by restoring the physiological conditions of the tissues present in the joints. This, in turn, eases pain and discomfort and allows more extensive movement of the joints.

Uses of undefined

Hylan polymer A&B G-F 20 is an intra-Articular Agents used to treat knee osteoarthritis by synovial fluid. Synovial fluid is responsible for viscosity in joints that helps in mobility.

undefined Drug administaration and Dosage available

Hylan will be administered to you by a doctor or other healthcare professional in the knee. Your doctor will decide the dose, route of administration, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age. Do not self-administer the injection. 

Warnings, Precautions and Side Effects of undefined


Notify your doctor if you have a knee joint infection, skin disease or infection on the injection site, or systemic bleeding disorders. Before receiving SYNVISC ONE, tell your doctor if you have severe knee inflammation, lymphatic or venous stasis (swollen or inflamed) in the leg to be injected, and chondrocalcinosis (accumulation of calcium pyrophosphate dihydrate (CPP) crystals in and around the joints).


Tell your doctor if you are pregnant, planning to get pregnant, or breastfeeding before taking this medicine. Before taking this medicine, talk to your doctor about all the medicines you have been taking recently, including supplements and herbal medicines. Consult your doctor for more information. Limited information is only available on the usage of children. In elders, this medicine should be used cautiously. Consult your doctor for more information. 

Side Effects

The most common side effects of Hylan polymer A&B G-F 20 are hypersensitivity reactions (anaphylactic shock, anaphylactoid reaction, angioedema). 

Some serious side effects of Hylan polymer A&B G-F 20 are joint pain, inflammation, and pain in the injection site.

Word Of Advice

Notify your doctor about all your underlying medication conditions. It is curious to tell your physician if you are pregnant or planning to get pregnant or breasting. Report to your doctor if you experience any side effects or new symptoms, and also mention if you take any other medicine before starting the treatment. Do not take this medicine if you are allergic to Hylan or its other ingredient. 

Frequently Asked Question


  1. yme Biosurgery, Genzyme Corporation, Sanofi-Aventtis Canada Inc, [Revised on 3rd Mar 2015] [Accessed on 3rd May 2023],
  2. Genzyme Biosurgery, Genzyme Europe B.V, Package insert, [Revised on Sep 2014] [Accessed on 3rd May 2023]
  3. Sanofi India, [Revised on Apr 2014] [Accessed on 3rd May 2023]


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.