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Author Details
Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 30 Jul 2026 | 09:35 AM (IST)
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Quick Summary
IDELALISIB
Last updated on 30 Jul 2026 | 09:35 AM (IST)
IDELALISIB
Background and Date of approval IDELALISIB
The U.S. FDA-approved Idelalisib to treat people with chronic lymphocytic leukemia (CLL) and follicular lymphoma on July 23, 2014.
Uses of IDELALISIB
Idelalisib is a targeted therapy medication that inhibits the delta isoform of PI3K (found in blood cells as B-cells and T-cells). By blocking PI3Kδ, Idelalisib disrupts signaling pathways that regulate cell survival, proliferation, and migration.
How is IDELALISIB administered?
Take Idelalisib as advised by your physician. Usually, this medicine will be given twice a day. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking Idelalisib if your doctor advises you to stop.
Side Effects of IDELALISIB
The most common side effects of Idelalisib are infections, liver damage, change in the number of WBC, increased liver enzymes, and lung inflammation.
Serious side effects while taking Idelalisib are reddish patches, changes in skin color, skin-peeling, mouth ulcers, ulcers in the throat, nose, genital, and eyes, skin rashes, fever, and dress syndrome (enlarged lymph nodes).
Warnings
Do not consume this medicine if you are allergic to Idelalisib, sunset yellow FCF (a petroleum-derived orange azo dye), and other ingredients of this medicine. Inform your physician if you have any conditions with the liver, lung (pneumonitis), kidney, intestinal perforation, neutropenia (low level of neutrophils), active infections/hepatitis, or skin reaction (Stevens-Johnson syndrome). Do not take this medicine if you are pregnant or think you might be pregnant or breastfeeding.
Precautions
Before starting with Idelalisib, notify your doctor about all your underlying medical conditions. Your doctor may regularly monitor you to check the injection and functions of the respiratory system, kidney, lungs, liver, and other organs. Depending on the response to the treatment and other side effects, your doctor may adjust your dosage of the Idelalisin tablet. Notify your doctor if you are planning toget pregnant. Use effective contraception.
Word of Advice
Keep out of sight and reach of pets and children. Store protected from light at a temperature not exceeding 30°C. Do not freeze. Oral contraception may be ineffective while under the treatment of Idelalisib. Discuss effective contraception methods with your doctor, along with fertility concerns. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. Your doctor may change your dose or stop the treatment based on your response. This medicine is not recommended for children or adolescents.
Frequently Asked Questions
Q1.
Why is it mandatory to use effective contraception during the treatment of Idelalisib tablet?
To avoid unwanted pregnancy, it is advised to use effective contraception. Oral contraception may be ineffective, so it is better to discuss effective contraception with your doctor.
Q2.
Is that okay to consume Idelalisib tablet with a lung condition?
No, Inform your doctor if you have lung conditions before starting Idelalisib. Not only lung conditions but also inform about kidney, liver, fever, infections, and other underlying medical conditions.
Q3.
Why is liver enzyme getting elevated during treatment with Idelalisib tablet ?
The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary and typically resolves on its own or with dose adjustment of the Idelalisib tablet.
Q4.
How can I manage diarrhea while taking Idelalisib tablet?
If you experience diarrhea while taking Idelalisib tablet , it is crucial to stay hydrated by drinking more fluids. Your physician may also recommend over-the-counter or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.
Q5.
My daughter is 12 years old. Can I use the Idelalisib tablet?
No, Idelalisib tablets should not be taken by children.
References
- Gilead Sciences Ireland UC, European Medicines Agency (EMA), [Revised on 20/05/2021] [Accessed on 10th May 2023], Zydelig | European Medicines Agency (europa.eu)
- Gilead Sciences, Inc.US Food and Drug Administration, [ Revised on Feb 2022] [ Accessed on 10th May 2023], , label (fda.gov)
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.
