This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Ketoconazole, Zinc pyrithione is a combination of antifungals that is approved and belongs to the therapeutic class of Dermatologics.

Mechanism of Action of undefined

Ketoconazole + Zinc pyrithione kills the fungus that causes dandruff and other scalp infections and reduces the amount of yeast and bacteria on the scalp. 

Uses of undefined

Ketoconazole + Zinc pyrithione is used to treat and prevent scalp conditions such as dandruff, seborrheic dermatitis, tinea capitis (scalp ringworm), and other scalp infections caused by yeast or bacteria. It is also used to prevent the recurrence of dandruff and seborrheic dermatitis and to promote healthy scalp and hair growth.

undefined Drug administaration and Dosage available

Ketoconazole + Zinc pyrithione is typically administered topically. The best route of administration depends on the individual's needs and preferences.

Warnings, Precautions and Side Effects of undefined


Ketoconazole + Zinc pyrithione can cause allergic reactions in some people. Symptoms of an allergic reaction may include hives, difficulty breathing, and swelling of the face, throat, or tongue. This medication can also cause contact dermatitis, a type of skin irritation.  Symptoms of contact dermatitis may include redness, itching, and burning on the scalp.


Stop and seek medical attention immediately if you experience allergic reactions after using Ketoconazole + Zinc pyrithione. If you experience symptoms like redness, itching, and burning on the scalp after using it, stop using it and talk to your doctor.

Side Effects

Ketoconazole + Zinc pyrithione can cause side effects in some people. The most common side effects are mild and temporary, such as scalp irritation, dryness, itching, burning, and hair loss. Serious side effects are rare but may include allergic reactions, contact dermatitis, severe redness and irritation, and skin peeling or blistering.

Word Of Advice

Avoid contact with eyes, nose, and mouth while using  Ketoconazole + Zinc pyrithione. If the medication gets into your eyes, rinse them immediately with water. If you have open wounds or cuts on your scalp, avoid using them until they have healed. Keep it away from open flames and heat sources. Use it as directed by your doctor or pharmacist. Do not use more than directed. If you experience any irritation or other side effects while using this medication, stop using it and talk to your doctor. Consult your doctor before using it if you are taking any other medications. If you use other hair products, such as conditioners or styling products, rinse them thoroughly before using this medication. If you have other scalp conditions, such as psoriasis or eczema, talk to your doctor before using this medication.

Frequently Asked Question


  1. Pinewood Laboratories Ltd., Electronic Medicines Compendium (EMC), [Revised on26 Oct 2021] [Accessed on 17th Oct 2023],
  2. Minji Park et al., Understanding the Mechanism of action of the Anti-dandruff agent Zinc Pyrithione against Malassezia Restricta, Scientific Reports, 2018, [Accessed on 17th Oct 2023]
  3. KD Tripathi, Antifungal Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 838-848.
  4. Suresh Sadhasivam et al., Newly Developed Anti-Dandruff Regimen, VB-3222, Delivers Enhanced Sensorial and Effective Therapeutic Benefits Against Moderate Adherent Dandruff, Clin Cosmet Investig Dermatol. 2020; 13: 187–195, [Accessed on 17th Oct 2023],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.