This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

L-Methylfolate contains an active component as L-Methylfolate. The active form of folate or vitamin B9 can be used directly by the body. Folate is an essential nutrient that plays a crucial role in various biological processes, including DNA synthesis, cell division, and the production of red blood cells. It is particularly important for individuals with certain genetic variations, such as MTHFR gene mutation. This mutation can impair the body's ability to convert synthetic folic acid (found in most supplements) into an active form.

Mechanism of Action of undefined

L-methylfolate has a range of therapeutic effects, including addressing folate deficiency and supporting essential biological processes such as DNA synthesis and cell division. It has shown promise as an adjunctive treatment for depression, potentially enhancing the effectiveness of antidepressant medications. In the context of psychiatric disorders like bipolar disorder and schizophrenia, this supplementation may be recommended due to its involvement in folate metabolism. Additionally, it plays a role in reducing the risk of neural tube defects during pregnancy and may be used in cardiovascular disease management.

Uses of undefined

L-Methylfolate is used for folate deficiency, depression, psychiatric disorders, cardiovascular disease, and prevention of neural tube defects.

undefined Drug administaration and Dosage available

When using L-methylfolate, following the instructions provided by your healthcare professional or the product packaging is important. Typically, it is taken orally with or without food. The dosage and frequency of use will depend on the specific medical condition being treated and individual needs.

Warnings, Precautions and Side Effects of undefined


L-methylfolate has a generally favorable safety profile, but some important warnings must be considered. Allergic reactions to L-methylfolate can occur. It may exacerbate symptoms in individuals with bipolar disorder and increase the risk of seizures in those with epilepsy. L-methylfolate can mask vitamin B12 deficiency symptoms, necessitating regular monitoring. Renal impairment may require dosage adjustments, and healthcare professionals should guide its use in children. 


Seek immediate medical attention if you experience rash, itching, swelling, dizziness, or difficulty breathing. It is crucial to be aware of associated warnings and closely follow healthcare provider instructions. If you are scheduled for surgery or medical procedures, inform your healthcare provider about your L-methylfolate use. Avoid alcohol consumption and regularly monitor vitamin B12 levels. Following these precautions will help ensure the safe and appropriate use of L-methylfolate based on your specific circumstances.

Side Effects

L-Methylfolate is generally well-tolerated, but it can potentially cause side effects in some individuals. Common side effects may include gastrointestinal upset like nausea, bloating, or gas. Allergic reactions, although rare, can manifest as rash, itching, swelling, dizziness, or difficulty breathing. 

Word Of Advice

It is important to exercise caution and follow these general recommendations when considering the use of L-methylfolate. Firstly, be aware of any known allergies or hypersensitivity to folate or related substances, and seek immediate medical attention if you experience signs of an allergic reaction. Use L-methylfolate with caution if you have bipolar disorder, epilepsy, or a history of seizures, and consult with your healthcare provider beforehand. Regular monitoring of vitamin B12 levels is advisable to detect any potential deficiency masked by this supplementation. Dosage adjustments may be necessary for individuals with renal impairment. Healthcare professionals should guide pediatric use. It is essential to inform your healthcare provider about all medications, pre-existing medical conditions, and scheduled procedures to ensure the safe and appropriate use tailored to your needs. These precautions will help minimize risks and promote optimal use in your healthcare regimen.

Frequently Asked Question


  1. Satyanarayana U, Chakrapani U, Biochemistry, Mineral metabolism, 4th edition, 2013, 405.
  2. Ramesh Kumar Saini et al; Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives; Pharmacological research; [Published on May 2020]; [Accessed on 19th June 20203];


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.