This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Lenalidomide is an antiangiogenic agent (a drug that blocks the formation of blood vessels) which was approved for its medical use on 27th December 2005.
Mechanism of Action of undefined
Lenalidomide is an antiangiogenic agent that works by inhibiting the formation of blood vessels that supplies nutrition to the cancer cells and facilitates the immune system attack against cancer cells. It activates T-cell and Natural Killer cells, suppresses inflammatory mediators like TNFα and other cytokines, arrests the cell cycle and induces programmed cell death of cancer cells. Lenalidomide is used in combination with other treatments like hemopoietic stem cell transplant, dexamethasone, or rituximab.
Uses of undefined
Lenalidomide has been developed to treat Multiple myeloma and myelodysplastic syndrome, mantle cell lymphoma and follicular lymphoma.
undefined Drug administaration and Dosage available
Lenalidomide is available in the form of capsule in the doses 2.5mg, 5mg, 10mg, 15mg, 20mg, and 25mg. You shall take Lenalidomide capsule with or without food by swallowing the capsule with water once a day. If you have kidney problem, your healthcare provider will adjust the dose after measuring your creatinine clearance.
Warnings, Precautions and Side Effects of undefined
Contact your doctor immediately if you experience shortness of breath, abnormal bleeding, or extreme tiredness. During the Lenalidomide treatment, your doctor may periodically monitor your blood cell counts, platelets, blood sugar, electrolytes, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with anemia, liver problems, kidney disease, heart problem, etc. Get immediate medical attention if you experience red itchy skin, rashes, peeling of the skin, yellowing of skin and eyes, severe itching, very fast heartbeat, or fever.
It is not recommended to get pregnant or breastfeed during treatment with Lenalidomide. Tell your physician before starting this treatment if you are pregnant, breastfeeding, think you could be pregnant or planning to have a baby. Discuss effective contraceptive methods with your physician and use them to prevent pregnancy. Your healthcare provider will conduct pregnancy test every 4 weeks if your menstrual cycle is regular and every 2 weeks if irregular.
The common side effects that are likely to occur while you are on the treatment with Lenalidomide are diarrhoea, rash, nausea, constipation, tiredness, weakness, fever, itching, bronchitis, inflammation of the stomach and intestine, muscle cramps, headache, sleep problems, cough, sore throat, joint pain, nosebleeds, back pain. Serious side effects include thyroid problems, dizziness, confusion, tumor lysis syndrome, secondary cancers, liver problems, low blood cell counts. If you experience any allergic reactions such as swelling of lips, eyes, face, or tongue, hives, breathing trouble, report to your doctor immediately.
Word Of Advice
Lenalidomide can cause dizziness and confusion. Therefore, it is advisable to avoid driving or doing activities that require your focus during this treatment. Tell your healthcare provider if you have lactose intolerance.
Frequently Asked Question
1. Bristol Myers Squibb, US Food & Drug Administration, [Revised on May 2022] [Accessed on 7th Sep 2022], https://packageinserts.bms.com/pi/pi_revlimid.pdf
2. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.