This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Lenvatinib is composed of the active ingredient Lenvatinib. It is a tyrosine kinase inhibitor indicated for progressive or advanced thyroid cancer when radioactive iodine therapy is not beneficial. It is also used to treat previously untreated liver cancer patients who are not eligible for surgical treatment. Patients who have had an allergic reaction to lenvatinib or any of its components should not take this medication. Patients should inform their dentist or oral surgeon that they are taking this medication, as it can impair wound healing and increase the risk of bleeding.

Lenvatinib was first approved by the United States Food and Drug Administration (FDA) in February 2015 for the treatment of locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer. Since then, it has received additional approvals for other indications, including the treatment of hepatocellular carcinoma (liver cancer) and renal cell carcinoma (kidney cancer).

Mechanism of Action of undefined

Lenvatinib blocks the enzyme receptor tyrosine kinases (RTKs). RTKs develop new blood vessels that supply oxygen and nutrients to the cells and help them grow. This medicine inhibits the receptors that facilitate the growth of blood vessels in tumor cells. RTKs are present in high concentrations in cancer cells, and administration of this medicine slows down the rate of cancer cells’ growth and multiplication.

Uses of undefined

Lenvatinib is a medication that is used to treat several types of cancer, including thyroid, liver, and kidney cancer. In patients with radioactive iodine-refractory differentiated thyroid cancer, it can be used to slow the progression of the disease and reduce tumor size. It is also approved for the treatment of unresectable hepatocellular carcinoma (HCC), which is the most common type of liver cancer.

undefined Drug administaration and Dosage available

Lenvatinib is an oral medication that is usually taken once a day, at approximately the same time each day, with or without food. It should be taken as prescribed by a doctor or other healthcare provider. These capsules should be swallowed whole with a glass of water. They should not be crushed, chewed, or opened, as this can affect the way the medication is absorbed and decrease its effectiveness. You should not take a double dose to make up the second dose.

Warnings, Precautions and Side Effects of undefined


Lenvatinib can cause an increase in blood pressure and increase the risk of heart attack, stroke, and other cardiovascular events. This medication can increase the risk of bleeding or hemorrhage and impair wound healing. It can cause kidney damage or kidney failure which results in proteinuria (an abnormal amount of protein in the urine). Sometimes it can cause hypothyroidism or other thyroid dysfunction. In rare cases, this medication can cause a condition called reversible posterior leukoencephalopathy syndrome (RPLS), which can cause seizures, confusion, and other neurological symptoms.


Patients taking lenvatinib should monitor their blood pressure regularly, and if hypertension is not well-controlled, the dose needs to be adjusted or treatment may need to be stopped. Patients with a history of cardiovascular disease, history of bleeding, or taking blood thinners require close monitoring. Patients should inform their healthcare provider if they plan to have any surgical procedures during treatment as this medication increases the risk of bleeding. You should do urine tests regularly for protein checks and any signs of kidney problems while taking this medication. Women of reproductive age should use effective contraception while taking it and for at least one week after the last dose. You should do thyroid function testing regularly while taking and if there are signs of thyroid dysfunction tell your doctor immediately.

Side Effects

Lenvatinib can cause several side effects, some of which can be serious. Common side effects include fatigue, decreased appetite, weight loss, muscle pain, nausea, vomiting, and diarrhea. Patients may also experience high blood pressure. Other potential side effects include liver damage, blood clotting problems, and heart problems. Patients should be monitored closely for signs of liver damage, such as yellowing of the skin or eyes, dark urine, or abdominal pain. It can also increase the risk of blood clots, which can be life-threatening. This medication can cause serious heart problems, including heart attack, stroke, and heart failure.

Word Of Advice

If you are receiving close communication with your healthcare provider and report any concerns or side effects as soon as possible. Avoid getting pregnant and breastfeeding during treatment. Patients should avoid eating grapefruits as they affect the absorption of this drug. Patients should use sunscreen and wear protective clothing while outdoors to reduce the risk of sunburn or skin damage. You should avoid strenuous activities or exercise until you know how this medication is affecting you. Maintain a healthy and balanced diet during treatment to support your overall health and well-being. By being informed and engaged in your treatment, you can help ensure the best possible outcomes and manage any potential risks or complications associated.

Frequently Asked Question


  1. Eisai Europe Limited, Electronic Medicines Compendium (EMC), [Revised on Mar 2021] [Accessed on 20th April 2023],
  2. Suyama and Iwase, Lenvatinib: A promising molecular targeted agent for multiple cancers, Cancer Control, 2018, 25, 1-5, 1073274818789361.pdf
  3. Q.M. Anstee, D.E.J. Jones, Liver and Biliary Tract Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 921-988.
  4. M.W.J. Strachan, J. Newell-Price, Endocrine disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 733-796.
  5. Eisai Inc U.S Food and Safety Drug Administration (FDA) [Last revised Aug 2018], [Accessed on 20th April 2023],


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.