Megestrol is an anticancer, antianorexia and anticachectic medication that was approved for its medical use in September 1993.

Megestrol Tablet has been developed to treat hormone-dependent cancer like endometrial and breast cancer. Its off-label indications include treatment of cancer-related loss of appetite (anorexia) and muscle loss (cachexia).

Megestrol is available as a tablet in doses 40mg and 160mg. The initial dose is 40mg four times a day and the maximum dosage is 800mg. The dosage and frequency vary according to the type of cancer.

The common side effects that are likely to occur while you are on the treatment with Megestrol Tablet are weight gain, high blood sugar, constipation, diarrhea, impotence, rashes, flatulence, asthenia, pain and changes in urine frequency. Call your healthcare provider if you experience allergic reactions, high blood pressure, chest pain, hot flashes, mood swings or any other discomfort after taking this medicine.

Megestrol Tablet is not recommended for those who are hypersensitive to Megestrol or its ingredients. Tell your doctor if you still get your periods. During the Megestrol Tablet treatment, your doctor may periodically monitor your blood sugar levels and check for the presence of adrenal suppression to prevent serious complications. Report to your doctor if you have HIV, endocrine disease, psychiatric disorders, thrombophlebitis, heart problem, liver disease or kidney problem. 

Megestrol Tablet may cause fertility problems in men and women. This Tablet is not recommended for pregnant women due to its ability to cause fetal harm and miscarriage. Inform your healthcare provider before starting this treatment if you are pregnant or planning to have a baby. Pregnancy testing is recommended for women of reproductive potential before starting Megestrol treatment. Discuss effective contraceptive methods to use during treatment with Megestrol and notify your healthcare provider right away if you get pregnant during this treatment. Do not breastfeed during treatment as Megestrol can pass into the breastmilk and cause potential harm to the baby.

If you feel tired or weak, you should avoid driving or handling machines. Tell your physician before taking this medicine if you are taking any other prescription medications, over-the counter drugs or supplements.

1. AA Pharma Inc., [Revised on Sep 2021] [Accessed on 1st Oct 2022], https://www.aapharma.ca/downloads/en/PIL/2021/Megestrol_PM_EN.pdf

2. Chris Manikkuttiyil; Hoang Nguyen, Megestrol, StatPearls [Internet], [Revised on Jul 2022] [Accessed on 1st Oct 2022], https://www.ncbi.nlm.nih.gov/books/NBK559205/#:~:text=Megestrol%20is%20a%20synthetic%20form,the%20progesterone%20receptor%20than%20progesterone. 

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.