This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Meropenem belongs to the class of medications known as carbapenem antibiotics. EDTA (Ethylenediaminetetraacetic acid) is a chelating agent. Meropenem was first approved by the Food and Drug Safety Administration (FDA) in 1996. 

Mechanism of Action of undefined

Meropenem, a broad-spectrum antibiotic, disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). When combined with EDTA, a chelating agent, it can enhance Meropenem's effectiveness by affecting bacterial cell wall integrity or permeability, making certain bacteria more susceptible to its actions.

Uses of undefined

Meropenem+EDTA is often prescribed to treat serious infections, including complicated skin and skin structure infections, complicated intra-abdominal infections, bacterial meningitis, and pneumonia, among others.

undefined Drug administaration and Dosage available

Healthcare professionals typically administer Meropenem+EDTA in a hospital or clinical setting. The injection may be given as a slow infusion or intermittent intravenous (IV), depending on the treatment condition and the healthcare provider's instructions. Before administration, the healthcare professional will assess the patient's patient's medical history, current health status, and any known allergies or sensitivities.

Warnings, Precautions and Side Effects of undefined


Meropenem+EDTA may lead to severe allergic reactions, pseudomembranous colitis, rare central nervous system side effects, decreased blood cell counts, potential kidney damage in cases of overdose or prolonged use, and EDTA-induced hypocalcemia.


When using Meropenem+EDTA, it's important to be vigilant for potential allergic reactions, especially in individuals with a history of antibiotic or chelating agent sensitivities. Monitoring for signs of allergic responses is crucial. Caution should be exercised in patients with prior Clostridium difficile infections, seizures, or central nervous system disorders due to possible severe complications. Regular monitoring of blood cell counts and kidney function is recommended due to rare associated risks. Adhering to prescribed dosages and promptly reporting any concerning symptoms to a healthcare professional is essential for safe and effective use.

Side Effects

Meropenem+EDTA, like any medication, may lead to various side effects, though not everyone will experience them. Serious effects include severe allergic reactions, pseudomembranous colitis, rare central nervous system side effects, decreased blood cell counts, potential kidney damage in cases of overdose or prolonged use, and EDTA-induced hypocalcemia. Common side effects encompass diarrhea, nausea, vomiting, headaches, rashes, itching, injection site reactions (if administered intravenously), and alterations in blood tests like liver function.

Word Of Advice

Patients should inform their healthcare providers about any known allergies or previous adverse reactions to Meropenem+EDTA or other antibiotics. Close monitoring of kidney and liver function is essential, especially in patients with pre-existing conditions affecting these organs. Proper dosage adjustment is crucial, considering factors such as the patient's weight, age, and renal function. Patients should complete the full course of treatment as prescribed, even if they start feeling better. Pregnant and breastfeeding women should consult their healthcare providers before using it. Patients should promptly report any severe or concerning side effects experienced during treatment. This medication should be used cautiously in the elderly and pediatric populations, with dosages adjusted accordingly. These precautions aim to maximize the benefits of this medication while minimizing the risk of side effects and antibiotic resistance.

Frequently Asked Question


  1. Sun Pharmaceutical Industries Europe B.V., Electronic Medicines Compendium (EMC),  [Revised date January 2022) (Accessed on 1/11/2023]
  2. Braun Medical Inc, Food and Drug Safety Administration (FDA)  [Revised on May 2020] [Accessed date 11/11/2023]
  3. KD Tripathi MD. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology 8th edition. Page – 731.


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.