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Author Details
Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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Quick Summary
MESALAZINE
Last updated on 31 Mar 2026 | 09:31 AM (IST)
MESALAZINE
Background and Date of approval MESALAZINE
The U.S. FDA approved Mesalazine on January 16, 2007. Mesalazine is an anti-inflammatory drug that belongs to the family known as aminosalicylates.
Uses of MESALAZINE
Mesalazine is used to treat ulcerative colitis and Crohn’s ileocolitis. Ulcerative colitis and Crohn's ileocolitis are inflammatory bowel diseases (IBD). Ulcerative colitis mainly inflames the colon and rectum, causing diarrhea and rectal bleeding. Crohn's ileocolitis affects the small intestine and colon, involving deeper layers of the intestinal wall and leading to abdominal pain, weight loss, and complications.
How is MESALAZINE administered?
Take the Mesalazine as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects of MESALAZINE
The most common side effects of Mesalazine are diarrhea, abdominal pain, nausea, headache, indigestion, bloating, and muscle pain. Serious side effects while taking Mesalazine are unexpected nose bleeds, bleeding gums, bruising more easily, problems with kidney function, a skin rash with flaking, boils, or sore lips, fever, sore throat, mouth or lip ulcers, spots underneath the skin, and swollen ankles.
Warnings
Do not take Mesalazine if you are allergic to Mesalazine, aspirin, salicylate, or any of its ingredients. Do not take this medicine if you have severe kidney disease or blood abnormalities while taking other medicines, such as sulphasalazine. This medicine is not for use in children under the age of 2. Inform your doctor if you have or have had a history of severe skin rash or skin peeling, blistering, and mouth sore.
Precautions
Before initiating Mesalazine treatment, your kidney and blood function will be assessed through tests. Your doctor will periodically monitor your liver, kidney, and blood health using blood and urine samples throughout your treatment. This medicine may lead to kidney stones, which could cause abdominal pain and blood in urine. Ensure proper hydration during the treatment.
Word of Advice
Follow the prescribed dosage and usage instructions provided by your healthcare professional. Inform your doctor about any known allergies or medical conditions you have before receiving Mesalazine. Do not consume this medicine if you have kidney related condition. Before stating the treatment inform your doctor if you have liver condition as this medicine is cautiously recommended in such conditions. If you notice any unexpected or severe side effects, like an allergic reaction, seek immediate medical attention. Inform your healthcare professional about any other medications or supplements you are consuming to avoid potential drug interactions. If you have any concerns regarding the treatment, consult your healthcare professional for information.
Frequently Asked Questions
Q1.
How can I manage side effects while taking Mesalazine?
If you observe any side effects while taking Mesalazine, stay hydrated by drinking plenty of fluids. Your medical professional may also recommend over-the-counter or prescription medications to help manage your symptoms. You should contact your physician if your side effects are severe or persistent.
Q2.
Can I give the Mesalazine to children?
No, the Mesalazine should not be given to children under 2 years of age. It's important to follow the recommended age guidelines and consult a healthcare professional for appropriate pediatric dosing and alternatives for younger children.
Q3.
Are there any dietary restrictions while taking Mesalazine?
There are no specific dietary restrictions associated with these medications. However, it is recommended to maintain a healthy and balanced diet to support overall health and well-being.
Q4.
Can Mesalazine be taken during pregnancy or while breastfeeding?
It is unsafe to consume Mesalazine during pregnancy and breastfeeding. Notify your healthcare professional if you are pregnant or planning to have a baby think you may be pregnant. Your doctor will decide whether you should use this medicine.
Q5.
How long does it take for Mesalazine to start working?
The time it takes for the Mesalazine to start working varies from person to person. However, it is important to continue taking the medication as your healthcare provider prescribes to achieve optimal treatment outcomes.
Q6.
What are the side effects of Mesalazine?
The common side effects of Mesalazine are diarrhea, abdominal pain, nausea, headache, indigestion, bloating, and muscle pain.
References
AbbVie Lt, Electronic Medicines Compendium (EMC), [Revised on May 2023] [Accessed on 31st August 2023].
Actavis Pharma, Inc., US Food and Drug Administration, [Revised on Sept 2015] [Accessed on 31st August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204412s006lbl.pdf
KD Tripathi, Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics, Essentials of Medical Pharmacology, 8th Edition, 2019, 209-226.
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.
