This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Metoclopramide contains the active component Metoclopramide. It is commonly used to treat gastrointestinal disorders. It works by increasing muscle contractions in the upper digestive tract, which helps speed up food movement and reduce nausea and vomiting. This benefit is particularly relevant for individuals with gastroparesis, a condition characterized by delayed stomach emptying. Metoclopramide was first approved by the U.S. Food and Drug Administration (FDA) in 1979 for gastrointestinal disorders.
Mechanism of Action of undefined
Metoclopramide exerts its therapeutic effects through its actions on multiple receptor systems. It is a dopamine receptor antagonist, primarily targeting D2 receptors in the brain and gastrointestinal tract. By blocking these receptors, it enhances the release of acetylcholine, a neurotransmitter that stimulates gastrointestinal motility and accelerates gastric emptying.
Uses of undefined
Metoclopramide is commonly used for the treatment of various gastrointestinal conditions. It is prescribed to relieve symptoms such as nausea, vomiting, and heartburn associated with gastroesophageal reflux disease (GERD) and diabetic gastroparesis.
undefined Drug administaration and Dosage available
To use metoclopramide effectively, following the instructions provided by your healthcare provider or the medication packaging is important. This medication is typically taken orally before meals, either in tablet or liquid form, as directed by your doctor. The dosage and frequency will depend on the specific condition being treated. It is crucial to adhere to the prescribed dose and schedule and not exceed the recommended duration of use.
Warnings, Precautions and Side Effects of undefined
Metoclopramide carries several important warnings. It may cause tardive dyskinesia, a potentially irreversible movement disorder, especially with long-term use. The medication can also lead to extrapyramidal symptoms resembling Parkinson's disease and in rare cases, neuroleptic malignant syndrome, a serious condition characterized by fever and muscle rigidity. It may cause sedation, impair alertness, and coordination, and can have gastrointestinal effects. It has been associated with depression, suicidal ideation, hypersensitivity reactions, and cardiovascular effects.
Individuals with known allergies to Metoclopramide or its components should avoid its use. Those with severe kidney impairment or kidney failure should exercise caution. Caution is needed in individuals with epilepsy, as it may lower the seizure threshold. It can interact with other medications, and caution should be exercised in pediatric and geriatric populations. Patients should avoid abrupt discontinuation after prolonged use as it may result in withdrawal symptoms.
Metoclopramide may cause various side effects. Common side effects include drowsiness, restlessness, fatigue, and gastrointestinal disturbances like diarrhea or constipation. It can also lead to movement disorders, such as dystonia or tardive dyskinesia, particularly with long-term use. Other potential side effects include changes in blood pressure, sedation, headache, and hormonal effects like increased prolactin levels.
Word Of Advice
It is important to inform your healthcare provider about any existing medical conditions, including liver or kidney impairment, epilepsy, or cardiovascular diseases. Close monitoring is needed in elderly patients and those with a history of movement disorders. Some individuals may experience hypersensitivity reactions to metoclopramide, including allergic reactions. Seek immediate medical attention if you develop rash, itching, swelling, or difficulty breathing. It should be used cautiously in individuals with a history of cardiovascular disease, arrhythmias, or other medications that can affect heart rhythm. Pregnant or breastfeeding individuals should seek medical advice before using it. This medication should be used cautiously in children, as they may be more susceptible to certain side effects, such as movement disorders. The benefits and risks should be carefully evaluated in pediatric patients.
Frequently Asked Question
- Hameln pharma Ltd, Electronic medicines compendium (EMC), [Revised on 26 Jan 2022], [Accessed on 9th June 2023], https://www.medicines.org.uk/emc/product/6283/pil#gref
- ANI Pharmaceuticals, Inc, US Food and Drug Administration, [Revised on August 2017],[Accessed on 9th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017854s062lbl.pdf
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.