This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Midostaurin is an anticancer medication which was approved for its medical use on April 2017.

Mechanism of Action of undefined

Midostaurin is an anticancer medication belonging to the category of medications called kinase inhibitors. It acts against the receptors and proteins that facilitate the mutation of FLT3 gene, interrupts cancer cell signaling, and eventually stops the growth and spread of cancer cells.

Uses of undefined

Midostaurin is a prescription medicine developed to treat acute myeloid leukemia caused by a mutation in FLT3 genes. It is also indicated to treat aggressive system mast cytosis, systemic mast cytosis with hematological neoplasm, and mast cell leukemia.

undefined Drug administaration and Dosage available

Midostaurin is available in form of Capsules in the dose 25mg. The usual recommended dosing is 50mg twice daily with food for acute myeloid leukemia and 100mg twice daily for aggressive systemic mast cytosis and systemic mast cytosis. Swallow Midostaurin Capsule whole with a glass of water.

Warnings, Precautions and Side Effects of undefined


Midostaurin not recommended for patients who are allergic to Midostaurin, or its ingredients. It is essential to let your physician know if you are diagnosed with problems in your kidneys or liver. Your physician will regularly monitor your blood cell count, blood pressure, cholesterol, liver and kidney parameters to prevent complications. Seek immediate medical attention if you experience worsening cough, chest discomfort or shortness of breath.


Midostaurin can affect the fertility of male and female patients. Female patients and female partners of male patients should avoid getting pregnant during this treatment. Tell your healthcare provider if you are pregnant, think you might be pregnant, breastfeeding or planning to have a baby. Discuss effective contraceptive methods with your healthcare practitioner and continue using birth control methods for 4 months after the final dose of Midostaurin. Do not breastfeed during and 4 months after the last dose of Midostaurin capsule.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Midostaurin Capsule are nausea, vomiting, diarrhoea, tiredness, constipation, nose bleeds, muscle or bone pain, upper respiratory tract infection, bruising, mouth ulcers, headache, fever, trouble breathing, high blood sugar levels, stomach pain, swelling of hands and feet. If you experience any allergic reactions or any other symptoms like shortness of breath, chills, or swelling, report to your doctor immediately.

Word Of Advice

Avoid driving and operating machines while on treatment with Midostaurin Capsule if you feel dizzy. Your healthcare provider will prescribe medications to prevent nausea and vomiting due to Midostaurin treatment.

Frequently Asked Question


  1. Novartis, US Food & Drug Administration, [Revised on Nov 2021] [Accessed on 25th Oct 2022],
  2. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.