This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Myo-Inositol, D-Chiro-Inositol, and L-Methylfolate, a unique combination, are widely used to support women’s reproductive and metabolic health, especially in conditions like polycystic ovary syndrome (PCOS). Myo-inositol and D-chiro-inositol are natural compounds that belong to the vitamin B complex group and help regulate insulin and ovarian function. L-Methylfolate is the active form of folic acid, essential for fertility, fetal development, and mood balance. Together, they help correct hormonal imbalances, improve menstrual regularity, and support ovulation.

While individual components like L-Methylfolate have received FDA approval for specific conditions like folate deficiency and depression, the combination itself is often marketed as a dietary supplement and not a prescription drug. Clinical studies published since the early 2010s have shown positive outcomes in women with PCOS and insulin resistance, especially when used over 3 to 6 months.

Mechanism of Action of undefined

These three ingredients work together to support overall hormonal and reproductive health, especially in women with PCOS. Myo-inositol helps the body use insulin more effectively and supports the healthy development of eggs in the ovaries. D-chiro-inositol works alongside it to balance male hormones (androgens) in women and helps improve ovulation. L-Methylfolate, a special form of folate, plays a key role in making DNA and red blood cells, while also supporting mood and nerve health. 

When combined, these ingredients help regulate hormones, improve menstrual cycles, and maintain stable blood sugar levels, which are common concerns in PCOS. With regular use, this combination can help restore natural ovulation and improve fertility outcomes over time.

Uses of undefined

A combination of Myo-Inositol, D-Chiro-Inositol, and L-Methylfolate is commonly used for the following purposes:

  • Management of PCOS (polycystic ovary syndrome)
  • Regulation of menstrual cycles
  • Improving ovulation and fertility in women
  • Supporting healthy insulin levels and metabolic function
  • Enhancing folate levels, especially in women trying to conceive
  • Supporting mood and neurological function in folate-deficient individuals

undefined Drug administaration and Dosage available

This combination is usually available in oral tablets or powder sachets. It is typically taken once or twice daily, depending on the formulation and the doctor’s recommendation. Common dosages include 2000 mg of Myo-inositol, 50–100 mg of D-chiro-inositol, and 200–400 mcg of L-Methylfolate per serving. It can be taken with or without food, but consistency is key for long-term benefits. Powder forms are often mixed with water and consumed daily.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Do not use if allergic to inositol or folate-containing compounds.
  • Avoid combining with antidepressants or antiepileptic drugs without medical advice.
  • Not suitable for individuals with bipolar disorder unless closely monitored.
  • Consult a doctor if you are on medications for diabetes, as blood sugar levels may fluctuate.
  • Excessive folate intake may mask symptoms of vitamin B12 deficiency.

Precautions

Before starting this supplement, inform your doctor about any underlying health conditions such as thyroid disorders, diabetes, or mood disorders. Pregnant and breastfeeding women should only use it under medical supervision, even though it's generally safe. Avoid taking multiple supplements that also contain folate or inositol to prevent overdosing. Stick to the recommended dose and monitor your cycle and symptoms regularly to track progress.

Side Effects

This supplement is generally well-tolerated, but some users may experience mild side effects.

Common side effects:

  • Nausea
  • Bloating or gas
  • Headache
  • Mild stomach discomfort

Serious side effects (rare):

  • Allergic reactions such as itching, rash, or swelling
  • Dizziness or difficulty breathing (in case of folate sensitivity)
  • Mood changes (very rare with high-dose methylfolate)

Always consult your doctor if you experience any unusual or prolonged symptoms.

Word Of Advice

This supplement works best when paired with a healthy lifestyle. Maintaining a balanced diet, managing stress, exercising regularly, and avoiding refined sugars can significantly improve your results. Don’t expect overnight changes as hormonal balance and metabolic improvements take time. Most women see benefits in 2 to 3 months. Always buy from reputable brands with clinical backing and avoid self-medication.

Frequently Asked Question

Disclaimer

The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.