This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Nandrolone Decanoate is an anabolic steroid primarily used in the treatment of conditions involving muscle wasting, chronic anemia, and osteoporosis. It mimics the effects of natural male hormones (androgens) and helps increase muscle mass, bone density, and red blood cell production. Unlike testosterone, Nandrolone has a greater anabolic effect than androgenic effect, making it a preferred choice in clinical settings where tissue-building is required without strong masculinizing side effects.

Nandrolone Decanoate was approved by the U.S. FDA in the 1980s for the treatment of anemia of chronic kidney disease and has since been used in multiple countries for other indications, including osteoporosis and muscle wasting. In India, it is commonly prescribed under endocrinology, oncology, and rehabilitation care. The drug is available in the form of intramuscular injections, typically administered every 1 to 4 weeks depending on the condition.

Mechanism of Action of undefined

Nandrolone Decanoate works by binding to androgen receptors in the body, which triggers protein synthesis and inhibits protein breakdown. This leads to enhanced muscle growth and improved nitrogen retention. It also stimulates the bone marrow to produce more red blood cells, which is beneficial in treating certain types of anemia. Additionally, Nandrolone promotes calcium retention and bone mineralization, which helps in managing osteoporosis.

Unlike some anabolic agents, Nandrolone does not convert readily to dihydrotestosterone (DHT), reducing the risk of certain androgenic side effects. However, it may aromatize to estrogen in small amounts, which can cause hormonal side effects if not monitored.

Uses of undefined

Nandrolone Decanoate is used for:

  • Management of anemia associated with chronic kidney disease
  • Treatment of osteoporosis in postmenopausal women
  • Supportive therapy in patients with muscle wasting due to HIV/AIDS, cancer, or severe illness
  • Adjunctive therapy in delayed growth and development (off-label in some cases)
  • Palliative management in certain hormone-sensitive cancers (under supervision)

undefined Drug administaration and Dosage available

Nandrolone Decanoate is administered as a deep intramuscular injection, typically in the gluteal region. The injection is usually given every 1 to 4 weeks depending on the condition being treated. Commonly available strengths include 25 mg/mL, 50 mg/mL, and 100 mg/mL ampoules.

The dosing regimen is individualized by the physician based on the patient’s clinical condition, body weight, and response to therapy. In anemia and wasting syndromes, doses are typically higher and given more frequently. In osteoporosis, lower maintenance doses are used. Healthcare providers ensure sterile technique during injection to minimize the risk of site reactions and infections.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Do not use in patients with prostate cancer, male breast cancer, or suspected hormone-sensitive tumors.
  • Contraindicated in severe liver disease or active hepatic tumors
  • Avoid in pregnancy and lactation due to risk of fetal virilization and hormonal disruption.
  • Risk of virilization (male characteristics) in female patients if used improperly or in high doses
  • May increase the risk of fluid retention, especially in patients with heart, kidney, or liver disorders

Precautions

Before starting Nandrolone Decanoate, inform your doctor if you have a history of liver problems, cardiovascular disease, kidney impairment, or hormone-related cancers. Female patients should be carefully monitored for signs of virilization, including deepening of the voice, hair growth, and menstrual irregularities. Long-term use may affect lipid profiles and liver enzymes, so regular blood tests are recommended.

Patients undergoing surgery or serious medical procedures should inform their medical team about Nandrolone use. Do not take other hormone or steroid medications without medical advice. If you're using the injectable form, only a trained healthcare professional should administer it to reduce the risk of injection-site issues. Patients with diabetes should monitor blood glucose closely, as Nandrolone can influence insulin sensitivity.

Also, regular prostate checks are advised for older male patients, as anabolic steroids may increase prostate size or PSA levels.

Side Effects

Common Side Effects:

  • Acne
  • Hair growth changes
  • Fluid retention or swelling
  • Injection site pain
  • Increased libido

Serious Side Effects:

  • Liver dysfunction (jaundice, dark urine)
  • Gynecomastia (breast enlargement in men)
  • Prostate enlargement
  • Mood swings, aggression
  • Menstrual irregularities in women
     

Word Of Advice

Nandrolone Decanoate.NPP should not be used for bodybuilding or athletic performance enhancement due to health risks and legal restrictions. Patients should undergo regular health checks including hormone levels, liver function, and cardiovascular status. Inform any surgeon or emergency care provider that you are using this medication. Report any sudden behavioral changes or unusual symptoms to your doctor.

Frequently Asked Question

References

  1. https://precision.fda.gov/ginas/app/ui/substances/6PG9VR430D
  2. https://www.federalregister.gov/documents/2010/08/10/2010-19698/determination-that-deca-durabolin-nandrolone-decanoate-injection-200-milligramsmilliliter-1
  3. https://archive.hshsl.umaryland.edu/server/api/core/bitstreams/a8ec092c-db24-4c6d-9475-440247d14d69/content
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC7696474/

Disclaimer

The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.