This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Nortriptyline + pregabalin + methylcobalamin contains an active component as Nortriptyline, pregabalin, and methylcobalamin. Nortriptyline is an antidepressant medication that belongs to the class of drugs known as tricyclic antidepressants (TCAs). Pregabalin is an anticonvulsant and antiepileptic medication used to treat neuropathic pain, especially in diabetic neuropathy, postherpetic neuralgia, and fibromyalgia. Methylcobalamin is a form of vitamin B12, an essential nutrient for the body. It is used as a dietary supplement to treat vitamin B12 deficiency, which can lead to anemia and nervous system problems. 

Mechanism of Action of undefined

These medications prescribed by healthcare professionals in specific cases where the patient's medical condition requires multimodal treatment. For example, some individuals with neuropathic pain may benefit from a combination of nortriptyline and pregabalin as they work through different mechanisms to address pain and may have a synergistic effect. Nortriptyline works by affecting the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which play a role in regulating mood and pain perception. Pregabalin works by reducing the release of certain neurotransmitters in the brain, which helps to decrease pain signals and alleviate anxiety symptoms. Methylcobalamin can be added to support nerve health and potentially enhance the treatment outcomes.

Uses of undefined

Nortriptyline + pregabalin + methylcobalamin is used to treat neuropathic pain.

undefined Drug administaration and Dosage available

Nortriptyline + pregabalin + methylcobalamin can be administered orally in tablet form. The specific usage instructions may vary depending on the condition being treated and the form of the medication. Oral tablets are typically taken with water, as directed by the healthcare provider. 

Warnings, Precautions and Side Effects of undefined


Nortriptyline + pregabalin + methylcobalamin may pose potential risks and require careful consideration due to their respective side effect profiles. Nortriptyline can cause adverse effects such as dry mouth, drowsiness, and constipation, while more severe concerns include irregular heartbeat and an increased risk of suicidal thoughts, particularly in young adults. Pregabalin's common side effects involve dizziness, drowsiness, and weight gain, while more serious reactions include allergic responses, swelling, and mood changes, potentially leading to suicidal thoughts. Methylcobalamin, being a form of vitamin B12, is generally well-tolerated, but at high doses, it may cause rare side effects like diarrhea or skin rash.


When considering these medications, it is crucial to consult a qualified healthcare provider for an individualized assessment of potential benefits and risks. Pregnant individuals should exercise extra caution and consult their obstetrician to evaluate the appropriateness of this combination during pregnancy, as certain medications may not be safe during this time.

Side Effects

Nortriptyline + pregabalin + methylcobalamin may cause various side effects, though not everyone will experience them. Serious side effects include allergic reactions, swelling of hands/feet, unusual bleeding or bruising, mood changes, suicidal thoughts, irregular heartbeat, and severe dizziness/fainting. Common side effects comprise constipation, dry mouth, headache, drowsiness, diarrhea, weight gain, and blurred vision.

Word Of Advice

If you have prescribed Nortriptyline + pregabalin + methylcobalamin for neuropathic pain, follow your healthcare provider's instructions carefully. Monitor for unusual symptoms, such as mood changes and irregular heartbeat. If you experience any unusual or severe side effects while taking these medications, contact your doctor immediately. Pregnant or breastfeeding individuals should inform their obstetrician or healthcare provider before using this combination, as certain medications may not be safe during pregnancy or lactation. Regularly attend follow-up appointments and communicate openly with your healthcare provider about any concerns or questions for a successful and safe diabetes management journey. 

Frequently Asked Question


  1. Ram Prabhoo et al., Efficacy and Tolerability of a Fixed Dose Combination of Methylcobalamin and Pregabalin in the Management of Painful Neuropathy, [Revised on 4/11/2012] [Accessed on 19/07/2023],
  2. Yasmin U Dongre et al., Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience [Revised on 19/5/2013] [Accessed on 19/07/2023],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.