This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Paclitaxel is a chemotherapeutic anticancer treatment drug which was approved for its medical use on December 1992.

Mechanism of Action of undefined

Paclitaxel is a chemotherapeutic agent that belongs to the category of medications called microtubule inhibitors. microtubules are structures that aid in the growth and development of cancer cells. Paclitaxel works by inhibiting these structures, ultimately stopping the multiplication of cancer cells. Paclitaxel is prescribed alone and also in combination with other anticancer medications.

Uses of undefined

Paclitaxel has been developed to treat certain forms of breast cancer, ovarian cancer, non-small cell lung cancer and AIDS-induced Kaposis sarcoma in patients who have not responded well to previous anticancer therapies.

undefined Drug administaration and Dosage available

Paclitaxel is available in the form of injection in the doses 30mg, 100mg, 260mg and 300mg. Your healthcare provider will calculate the ideal dose according to your condition and administer it as an intravenous infusion after dilution.

Warnings, Precautions and Side Effects of undefined

Warnings

It is not recommended to take Paclitaxel Injection if you are allergic to Paclitaxel, polyoxyethylated castor oil or any of its ingredients. During the Paclitaxel treatment, your doctor may periodically monitor your complete blood counts, blood sugar, electrolytes, liver panel, and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with stomach ulcers, anaemia, lung disease, problems in your heart, liver, skin, kidneys. Tell your physician before you undergo surgery or dental procedures. Seek immediate medical attention if you experience severe stomach pain, diarrhea or vomiting that does not go away.

Precautions

 It is not known if Paclitaxel causes harm to an unborn baby. Tell your healthcare provider before beginning this treatment if you are pregnant or planning to have a baby. It is advised for both men and women to follow proper contraceptive methods during and for 3 months after the last dose of Paclitaxel. Avoid breastfeeding your baby while you are on the treatment and for 2 weeks after the last dose of Paclitaxel.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Paclitaxel are diarrhea, nausea, vomiting, hair loss, rashes, decreased blood counts, joint pain, muscle pain, infections, changes in liver function tests, abnormal heartbeat, decreased appetite, swelling of hands and feet, dehydration, numbness and tingling sensation. If you experience any allergic reactions, fever, breathing trouble or other unusual reactions after taking this medicine, report to your doctor immediately.

Word Of Advice

Ensure that you stay hydrated and maintain a balanced diet. Avoid driving or operating heavy machines if you experience dizziness or tiredness while on treatment with Paclitaxel. 

Frequently Asked Question

References

1. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Goodman & Gilman’s Pharmacological Basis of Therapeutics, Cytotoxic Drugs, 13th Edition, 2018, 1167-1201.

2. Pfizer, [Revised on Apr 2021] [Accessed on 5th Oct 2022], https://labeling.pfizer.com/ShowLabeling.aspx?id=4559

3. Abraxis BioScience, LLC., [Revised on Aug 2020] [Accessed on 5th Oct 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021660s047lbl.pdf

Disclaimer

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.