Palbociclib is an anticancer medication that was developed by Pfizer for treating breast cancer in postmenopausal women who tested positive for hormone receptors. It was initially approved in 2015 and later approved for treating metastatic breast cancer. Recently this medication has received a nod for its use in treating male breast cancer.

Palbociclib is used in the treatment of hormone-positive breast cancer. It is usually administered in combination with other hormonal therapy agents. Palbociclib is effective in treating breast cancer that has spread to other organs.

Palbociclib is intended for oral use only. It is often given along with other hormonal therapy agents. It must be consumed with meals and do not open/break the capsule. Palbociclib capsule is available in three different strengths 75mg capsule, 100 mg, and 125 mg capsules.

It is common to experience few side effects while on the treatment with Palbociclib. They include reduction of white blood cells, fatigue, loss of appetite, hair loss, dry skin, fever, visual changes, diarrhea, and vomiting.

Palbociclib is associated with causing harm to the unborn baby. Thus, it is suggested to consult your doctor if you are planning for pregnancy in the near future. Adequate birth control methods are to be strictly followed at least 3 weeks after the completion of treatment. Discuss with your doctor if you have had a history of allergy to sugar compounds in any form such as lactose, as this medicine consists of lactose. Avoid consuming grapefruit in any form during the course of treatment with Palbociclib. To avoid serious side effects, inform your doctor if you are taking any medications for treating cholesterol or heart diseases.

You must report your medication history to the doctor before starting with Palbociclib. If you are subjected to consuming antibiotics/antiviral/antifungal medications, inform your doctor beforehand to avoid serious complications. It is vital to monitor your blood cell counts thoroughly during the treatment with Palbociclib as this agent may cause a decline in the levels of platelets, and red and white blood cells. If you have liver disorders, inform your doctor before the treatment commences.

If you are experiencing any breathing difficulties, chest pain, or fever with chills, it is imperative to seek immediate medical support or report to the doctor, as it might be a sign of lung inflammation. It is considered best to consume this Palbociclib tablet every day at the same time, ideally with a meal. Exercise caution while driving or handling machines, as you may experience tiredness or dizziness while on the treatment with Palbociclib.  Avoid crowded places, wash your hands frequently, and consume home-cooked foods only to reduce the risk of infections.

1. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
2. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
3. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment