Phenylephrine was approved by the US Food and Drug Administration (FDA) on 20/12/2012 for increasing blood pressure in adults with clinically important hypotension.

Phenylephrine is used in adults to raise low blood pressure caused by septic shock or anesthesia, where blood vessels widen too much, causing a drop in blood pressure. It helps by narrowing the blood vessels and increasing blood pressure to normal levels.

Phenylephrine is available as a 10mg injection for intravenous use (injected into your vein) by your healthcare provider. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

Phenylephrine can cause some side effects like any other drug. Serious allergic reactions to phenylephrine injection may manifest as itching, rash, facial or throat swelling, breathing difficulties, or wheezing, requiring immediate medical attention. Common side effects include elevated blood pressure, increased heart rate, difficulty sleeping, vomiting, headaches, and shortness of breath. Additionally, you might experience challenges in passing urine, an inability to empty your bladder, and enlarged pupils, which can cause blurred vision. Be vigilant for these symptoms and promptly consult your healthcare provider if you encounter any of them during your treatment.

It is not recommended to take this medication if you are allergic to phenylephrine hydrochloride or any of its ingredients. It is important to inform your doctor if you are currently using or have stopped taking antidepressants recently. If you have high blood pressure, overactive thyroid (hyperthyroidism), prostatic enlargement, or any specific eye problem, inform your doctor promptly before taking this medication. Inform your doctor if you have diabetes, heart, liver, lung, or kidney disease before taking phenylephrine. Transparency with your doctor regarding your medical history and medications is crucial to ensure dimercaprol's safe and proper use.

Before taking phenylephrine, it's vital to inform your doctor if you are pregnant, planning to conceive, or breastfeeding before using phenylephrine injection, as it can potentially harm the fetus or pass into breast milk. If you have lung diseases or liver disorders, consult your physician before taking the medication. Avoid alcohol, which can intensify its effects. Additionally, if you feel dizzy during treatment, refrain from driving or operating machinery and seek advice from your doctor promptly. Safety is crucial; ensure open communication with your healthcare provider regarding any concerns.

When taking phenylephrine, it's important to remember a few key points for your well-being. If you are pregnant or breastfeeding, do not use this medication without your doctor's advice, as they can guide you on its safety for you and your baby. Additionally, avoid smoking while using phenylephrine, as tobacco use can worsen its effects. Your overall health is a priority, so follow these guidelines and consult your healthcare provider if you have any concerns or questions about your medication.

1. Amdipharm UK Limited Electronic medicines compendium (EMC), [Revised on Aug  2021], [Accessed on 16th Oct 2023], https://www.medicines.org.uk/emc/product/5577/pil
2. Éclat Pharmaceuticals, US Food and Drug Administration (FDA), [Revised on Mar 2023] [Accessed on 16th Oct 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/203826Orig1s015,017lbl.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Drugs Acting On Ans, 8th edition, 2019, 148.
4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Adrenergic Agonists And Antagonists, 2018, 202

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.