This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Phytomenadione was initially approved by the United States Food and Drug Administration (FDA) on June 19, 1941.

Mechanism of Action of undefined

Phytomenadione operates through its vital role as a cofactor for the enzyme gamma-glutamyl carboxylase, which adds carboxyl groups to specific amino acid residues in vitamin K-dependent proteins. This carboxylation process is essential for activating clotting factors such as prothrombin, VII, IX, and X, enabling them to participate in the coagulation cascade. These activated clotting factors, in turn, contribute to the formation of stable blood clots in response to injuries, preventing excessive bleeding and ensuring proper hemostasis.

Uses of undefined

Phytomenadione regulates blood clotting, reverses anticoagulant effects, prevents bleeding issues in newborns, supports bone health, and manages clotting function in conditions like malabsorption or liver disease. This medication also helps in hemostasis in gastrointestinal bleeding and treats coumarin-induced skin necrosis.

undefined Drug administaration and Dosage available

Phytomenadione can be administered through multiple routes, including oral ingestion through tablets or liquid, intravenous injection, and intramuscular injection into a muscle. The specific route chosen depends on the patient's condition, urgency of treatment, and healthcare provider's recommendation. 

Warnings, Precautions and Side Effects of undefined


Allergic reactions such as rash, itching, swelling, or difficulty breathing can occur with using Phytomenadione. Unusual bleeding, bruising, or bleeding that does not stop can be also seen. This medication could also affect clotting factors. Although rare, sensitivity to sunlight might occur.


If you experience signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek medical help immediately. If you notice unusual bleeding, bruising, or bleeding that does not stop, inform your healthcare provider. Inform surgeons or dentists about it before undergoing procedures. Do not stop using Phytomenadione abruptly without consulting your healthcare provider.  If taking anticoagulant medications like warfarin, follow your healthcare provider's recommendations closely. Use sun protection measures.

Side Effects

Side effects of Phytomenadione are generally rare and mild, with common ones including minor injection site discomfort or mild gastrointestinal symptoms. Serious side effects are uncommon but could involve severe allergic reactions with symptoms like rash, swelling, or difficulty breathing. In rare cases, unusual bleeding or bruising might occur.

Word Of Advice

Inform your healthcare provider of allergies, medical history, and medication use before starting  Phytomenadione. Discuss potential allergic reactions, unusual bleeding, or bruising. Pregnant or breastfeeding individuals should seek medical advice. Caution is advised for those with liver or lung conditions, and any interactions with alcohol should be discussed. Dosage, particularly for children and older adults, should be followed as directed by the healthcare professional. Before surgeries or dental procedures, inform professionals about your medication use. Regular monitoring and communication with healthcare providers are important for those taking anticoagulants. Avoid discontinuation without professional guidance. While sunlight exposure is not directly affected, sun protection remains important. Ultimately, consult your healthcare provider for personalized advice, ensuring safe and effective usage of this medication

Frequently Asked Question


  1. Neon Healthcare Limited, Electronic Medicines Compendium (EMC), [Revised on 16 Feb 2022] [Accessed on 19th August 2023],
  2. Valdepharm, US Food, and Drug Administration, [Revised on May 2018] [Accessed on 19th August 2023],
  3. P. Hanlon, M. Byers, J.P.H. Wilding and H.M. Macdonald, Environmental and nutritional factors in disease, Davidson’s Principles, and Practice of Medicine, 22nd Edition, 2014, 97-132.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.