This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Plazomicin is a strong antibiotic used to treat serious infections caused by bacteria, especially when other antibiotics don’t work anymore. It belongs to a group of medicines called aminoglycosides, which are often used for tough bacterial infections. What makes Plazomicin different is that it can still fight bacteria that have become resistant to older antibiotics.
The U.S. FDA approved it on June 26, 2018, after successful clinical trials called CARE and EPIC. These studies showed that Plazomicin works well for treating complicated urinary tract infections and certain blood infections caused by hard-to-treat bacteria. This approval was an important step in helping doctors fight infections that no longer respond to regular treatments.
Mechanism of Action of undefined
This antibiotic works by stopping the growth of harmful bacteria. It does this by attaching to the bacterial cells and blocking the production of proteins they need to survive and multiply. When these proteins are not produced, the bacteria can’t function properly and eventually die. What makes this drug powerful is that it’s been modified to resist the defences that many bacteria have developed against older antibiotics. This means it can still be effective even when other drugs no longer work.
Uses of undefined
Plazomicin is approved by the FDA to treat:
- Complicated urinary tract infections (cUTIs), including serious kidney infections.
- Infections caused by certain tough bacteria that don’t respond to other antibiotics, especially when other treatment options are not working or can’t be used.
undefined Drug administaration and Dosage available
This medicine is given as an injection directly into a vein (intravenous infusion), usually in a hospital setting under the supervision of a healthcare professional. It is typically administered once a day, and the duration of treatment depends on the severity and type of infection. The available strength is 500 mg per vial, and the exact dose is calculated based on the patient's body weight and kidney function. It is not available in tablet or oral form
Warnings, Precautions and Side Effects of undefined
Warnings
- Not recommended for patients with severe kidney impairment.
- Should not be used in combination with other drugs known to cause kidney or ear damage unless absolutely necessary.
- May interact with diuretics, certain antivirals, and chemotherapy drugs.
- Not advised for use in pregnant or breastfeeding women unless clearly needed.
- Close monitoring of kidney function and hearing is essential during treatment.
Precautions
Before starting treatment, it’s important to inform your doctor about any history of kidney problems, hearing issues, or previous allergic reactions to antibiotics. Since this drug is mainly cleared by the kidneys, people with reduced kidney function may require dose adjustments. Regular blood tests may be done to check for any harmful effects. Patients should stay well-hydrated and report any signs of hearing changes or balance issues immediately. Avoiding other medications that stress the kidneys or ears during treatment is also crucial.
Side Effects
Common side effects:
- Nausea
- Diarrhea
- Headache
- Dizziness
- Increased creatinine levels (a marker of kidney function)
Serious side effects:
- Kidney damage (nephrotoxicity)
- Hearing loss or ringing in the ears (ototoxicity)
- Balance issues or vertigo
- Allergic reactions such as swelling, rash, or trouble breathing
Anyone experiencing serious side effects should seek immediate medical help.
Word Of Advice
Since this drug is given by a healthcare provider in a clinical setting, patients should make sure to attend all scheduled doses and follow-up appointments. Do not skip or stop treatment early, even if symptoms improve, as this can lead to incomplete recovery and increased resistance. Let your doctor know about any unusual symptoms during the treatment. Avoid self-medicating or taking over-the-counter drugs without informing your healthcare team, especially painkillers like ibuprofen that may affect kidney function.
Frequently Asked Question
References
Disclaimer
The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.
