Uses of undefined

FDA-approved uses of this drug include:

• Chronic idiopathic constipation (CIC) – Long-term constipation without an identifiable cause
• Irritable bowel syndrome with constipation (IBS-C) – A functional bowel disorder characterised by abdominal pain and constipation

undefined Drug administaration and Dosage available

Plecanatide is available as an oral tablet and is typically prescribed in a 3 mg once-daily dose, which can be taken with or without food. The tablet should be swallowed whole and not crushed, split, or chewed to ensure proper release of the medication. It is approved for use in adults aged 18 years and older and is not recommended for children. The drug should be taken at the same time each day for consistent results. If a dose is missed, it should be taken as soon as remembered, but double dosing should be avoided.

Warnings, Precautions and Side Effects of undefined

Warnings

• Contraindicated in children under six years due to the risk of severe dehydration
• Should not be used in patients with known or suspected mechanical gastrointestinal obstruction
• Serious allergic reactions may occur; discontinue use if symptoms like swelling or breathing difficulties develop
• Potential drug interactions: Caution is advised when taken with other medications affecting bowel motility

Precautions

Before starting treatment, patients should inform their healthcare provider about any medical history related to gastrointestinal obstructions, severe diarrhoea, or hypersensitivity reactions. Since the medication increases fluid secretion in the intestines, dehydration is a potential risk, especially in elderly patients. Adequate hydration should be maintained throughout the treatment. Patients should also avoid splitting or crushing the tablet to ensure proper drug release and effectiveness.

Side Effects

Common Side Effects

• Diarrhea
• Bloating
• Gas
• Nausea
• Fatigue
• Upper respiratory tract infections

Serious Side Effects

• Severe diarrhoea leading to dehydration
• Severe abdominal pain
• Allergic reactions (swelling, difficulty breathing, rash)

Word Of Advice

Patients should start treatment under medical supervision, especially if they have a history of gastrointestinal issues. If diarrhoea occurs, stopping the medication and consulting a healthcare provider is recommended. Pregnant or breastfeeding women should discuss potential risks with their doctor. Since this medication is not approved for pediatric use, it should be kept out of children’s reach.

Frequently Asked Question

• What is the best time to take Plecanatide?
• Plecanatide can be taken at any time of the day, but taking it at the same time daily ensures consistency. It does not have stimulant properties, so timing does not affect its effectiveness. If a dose is missed, it should be taken when remembered unless it is close to the next scheduled dose.

• Should Plecanatide be taken before or after meals?
• Plecanatide can be taken before or after meals as food does not impact its effectiveness. Patients may choose a time that fits their routine to maintain consistency in dosing.

• How long does Plecanatide take to work?
• Relief from constipation can typically be noticed within 24 to 48 hours after taking the first dose. However, individual responses may vary, and full benefits may take a few days of consistent use.

• Can Plecanatide cause diarrhoea?
• Yes, diarrhoea is a commonly reported side effect. If it becomes severe, leading to dehydration or discomfort, it is important to discontinue the medication and seek medical advice. Staying hydrated can help reduce the risk of dehydration from diarrhoea.

• Is Plecanatide safe for long-term use?
• Clinical studies have shown that Plecanatide is safe for long-term use in patients with CIC and IBS-C. However, regular follow-ups with a healthcare provider are recommended to monitor its effectiveness and any potential side effects over time.