This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Probenecid was initially approved by the United States Food and Drug Administration (FDA) on October 15, 1995.

Mechanism of Action of undefined

Probenecid works by inhibiting the reabsorption of uric acid in the kidneys, leading to increased excretion of uric acid in the urine. This mechanism helps lower uric acid levels in the blood, which is beneficial for conditions like gout and hyperuricemia. By promoting uric acid elimination, this medication reduces the risk of urate crystal formation in joints and tissues, alleviating gout symptoms and preventing its progression.

Uses of undefined

Probenecid, an antigout agent classified as a uricosuric agent, treats gout and hyperuricemia. Enhancing the excretion of uric acid in the urine helps lower elevated levels of uric acid in the bloodstream, preventing the formation of urate crystals in joints and tissues. Its therapeutic role lies in its ability to alleviate gout symptoms, reduce the frequency of gout attacks, and potentially prevent long-term joint damage associated with uric acid crystal deposition. It is an important option in managing these conditions, contributing to improved quality of life for individuals dealing with gout and hyperuricemia.

undefined Drug administaration and Dosage available

Probenecid is typically administered orally, which means it is taken by mouth as tablets or capsules. The medication is absorbed into the digestive system and enters the bloodstream, where it exerts its effects on uric acid metabolism and renal excretion. The oral route of administration is the most common and convenient way to deliver Probenecid to the body to treat conditions like gout and hyperuricemia.

Warnings, Precautions and Side Effects of undefined


Severe allergic reactions can occur, including rash, itching, swelling, and difficulty breathing. Blood disorders like agranulocytosis or hemolytic anemia may arise, leading to symptoms such as persistent fever, sore throat, or unusual bleeding. Kidney dysfunction can manifest, especially in individuals with impaired renal function. Serious skin reactions, though rare, may result in blistering, peeling, and lesions. Gout flare-ups might initially worsen before improvement. Interactions with other medications can impact their effectiveness or lead to unexpected outcomes. Alcohol consumption can interact with Probenecid and cause side effects. Dizziness, headaches, and gastrointestinal issues are possible. 


Stay vigilant for potential allergic reactions, such as rash and swelling, and seek immediate medical attention if they occur. Regularly monitor for blood disorders and kidney function, especially if you have a history of these conditions. If serious skin reactions or gout flare-ups manifest, discontinue use and consult a healthcare provider. Be cautious with alcohol consumption due to potential interactions, and inform healthcare providers about all medications being taken. Manage dizziness, headaches, and gastrointestinal upset, and promptly report any adverse effects. Adhere to prescribed dosages and maintain open communication with healthcare providers for guidance and monitoring.

Side Effects

Probenecid use may lead to side effects, ranging from common and generally manageable effects such as gastrointestinal upset, skin rash, headaches, dizziness, and joint pain to more serious reactions like severe allergic responses, blood disorders, and kidney dysfunction. While not everyone experiences these effects, it's crucial to promptly report any unusual or severe symptoms to a healthcare provider. Monitoring and open communication are key to managing potential side effects and ensuring this medication's safe and effective use.

Word Of Advice

Individuals with a history of allergies to Probenecid should exercise caution, and any potential allergic reactions should be promptly reported to a healthcare provider. Patients with kidney impairment or blood disorders must inform their healthcare provider, as dose adjustments or monitoring may be necessary. Its interactions with other medications require disclosing all current medications, including over-the-counter drugs and supplements, to the healthcare provider. Regular monitoring of uric acid levels, kidney function, and blood counts may be required, and maintaining proper hydration is essential. Dietary habits, such as purine intake, should be discussed with the healthcare provider. Pregnant or breastfeeding individuals should consult their healthcare provider before using this medication. Medical advice should be sought in cases of skin reactions, dizziness, or other unusual symptoms. Its potential interactions with alcohol should be understood, and alcohol consumption should be moderated or avoided. Lastly, adherence to the prescribed dosage, storage guidelines, and open communication with the healthcare provider is crucial for ensuring this medication's safe and effective use.

Frequently Asked Question


  1. Tillomed Laboratories Ltd, Electronic medicines compendium (EMC), [Revised on October 06, 2021] [ Accessed on August 09, 2023], [Revised on March 14, 2022] [ Accessed on August 10, 2023],
  2. Tilo Grosser, Emer M. Smyth, Garret A. FitzGerald, Pharmacotherapy of Inflammation, Fever, Pain, and Gout, Goodman & Gilman's Pharmacological Basis of Therapeutics, 13th Edition, 2018, 685-709.


The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.