Progesterone is a synthetic hormone commonly prescribed for various medical purposes, designed to mimic the natural effects of the body's progesterone. It is often used in hormone replacement therapy for menopausal women or to regulate the menstrual cycle in cases of irregular periods.

• Progesterone in oral capsule form (e.g., Prometrium): The FDA initially approved Prometrium on October 8, 1998.
• Progesterone in injectable form (e.g., Progesterone in Oil): The FDA initially approved Progesterone in Oil on November 20, 1981.

Progesterone medication is used for a range of therapeutic purposes. It is commonly employed in hormone replacement therapy (HRT) for menopausal women to alleviate symptoms like hot flashes and vaginal dryness. It is also utilized in fertility treatments to support pregnancy and reduce the risk of miscarriage. Progesterone medication can help regulate menstrual cycles in cases of irregular or heavy bleeding and is used in certain contraceptive methods.

A healthcare provider gives this injection. The dosage and frequency will depend on the specific condition being treated. 

Side effects of progesterone can vary in severity. Common side effects may include fatigue, dizziness, headache, breast tenderness or swelling, bloating, nausea, mood changes, and changes in menstrual bleeding patterns. Although less common, serious side effects may include allergic reactions, blood clotting disorders, jaundice, severe abdominal pain, chest pain, or vision changes.

Progesterone medication carries several warnings that should be considered. These include the potential risk of allergic reactions, increased risk of blood clotting disorders, caution in hormone-sensitive conditions such as certain cancers, the possibility of mood changes or depression, the potential for interactions with other medications, and the need for prompt medical attention in the case of ectopic pregnancy. Additionally, there may be associations with breast cancer, effects on liver function, cardiovascular risks, effects on blood sugar levels, potential vision changes, and caution in individuals with asthma.

Individuals with known allergies to Progesterone or its components should avoid its use. Discuss your medical history and pre-existing conditions such as blood clotting disorders, hormone-sensitive conditions, or liver disease. It is crucial to follow the prescribed dosage and schedule and be aware of any potential interactions with other medications

It is important to inform your healthcare provider about any existing medical conditions, including liver or kidney impairment, epilepsy, or cardiovascular diseases. Some individuals may experience hypersensitivity reactions to Progesterone, including allergic reactions. Seek immediate medical attention if you develop rash, itching, swelling, or difficulty breathing. It should be used cautiously in individuals with a history of cardiovascular disease, arrhythmias, or other medications that can affect heart rhythm. Pregnant or breastfeeding individuals should seek medical advice before using it.  Do not smoke while taking this medication, as this may increase your chances of a blood clot.

1. Watson Laboratories Inc, US Food and Drug Administration, [Revised on 2007] [Accessed on 12th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017362s104lbl.pdf
2. MP Warren et al., Use of Progesterone in clinical practice, Int J Fertil Womens Med, 1999, 44(2):96-103. [Accessed on 12th June 2023], https://pubmed.ncbi.nlm.nih.gov/10338267/

The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.