This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Purified Vero Cell Rabies vaccine is composed of Purified Vero Cell Rabies Vaccine which is indicated to prevent and treat rabies before and after exposure to the virus. This vaccine is made by growing the rabies virus in these cells and then purifying it to remove unwanted substances. The purified virus is then inactivated, meaning it can no longer cause disease but still stimulate an immune response. Pre-exposure vaccination is for travelers, those in high-risk occupations, and children living in rabies-prone areas. Post-exposure prophylaxis refers to prompt wound management and vaccination. This vaccine is prepared from the Pitman-Moore strain of the Rabies virus grown in Vero cells.
Mechanism of Action of undefined
The Purified Vero Cell Rabies vaccine introduces inactivated rabies virus particles to the body. This exposure triggers an immune response, producing specific antibodies that recognize and target the rabies virus. If a vaccinated person subsequently encounters the virus, their immune system is primed to quickly recognize and neutralize it, preventing it from causing it.
Uses of undefined
Purified Vero Cell Rabies vaccine is used in Immunization before possible exposure to rabies, Post-exposure treatment after exposure to a suspected rabid animal and Prevention of infection for high-risk people (veterinarians, municipal workers, medical and paramedical workers).
undefined Drug administaration and Dosage available
The Purified Vero Cell Rabies vaccine is typically given as a series, with the exact schedule determined by healthcare professionals based on factors such as age, health status, and risk of exposure to rabies. The injections are usually given in the upper arm for adults and older children or in the thigh muscle for infants and young children.
Warnings, Precautions and Side Effects of undefined
The Purified Vero Cell Rabies Vaccine carries warnings for potential allergic reactions. Individuals with weakened immune systems may have reduced vaccine response. While rare, Guillain-Barré Syndrome (severe neurological disease) cases have been reported.
Precautions associated with the Purified Vero Cell Rabies Vaccine include ensuring the absence of severe allergic reactions to vaccine components, monitoring individuals with compromised immune systems for potential reduced vaccine response, assessing the risks and benefits for pregnant and breastfeeding individuals, avoiding vaccine administration errors, and considering individual medical conditions and medications that may interact with the vaccine. Adverse events should be reported for ongoing safety monitoring. Consultation with a healthcare professional is crucial to address specific concerns and make informed decisions.
Common side effects of the Purified Vero Cell Rabies Vaccine include pain, redness, or swelling at the injection site, headache, fatigue, muscle or joint pain, and mild fever. Serious side effects are rare but can occur like severe anaphylactic reaction (severe life-threatening allergic reaction).
Word Of Advice
If you are considering getting the Purified Vero Cell Rabies vaccine, you should know the potential risks and warnings associated with the vaccine. Pregnant and breastfeeding women should always consult a doctor before taking it. Inform your physician before beginning treatment if you have or ever had a mental illness, seizures, hepatitis infection, skin rashes, or any other signs of infection or inflammation. Reporting any adverse events is crucial for ongoing safety monitoring. Consulting with a healthcare professional is essential to address specific concerns and ensure appropriate vaccination decisions.
Frequently Asked Question
- Sudarshan MK. World Health Organization 2018 Guidelines on Rabies Prophylaxis: Contentious Issues. Pediatr Inf Dis 2019;1(4):154–156, https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1226
- Thomas Moulenat et al., Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019, Trop. Med. Infect. Dis., 2020, 5, 40, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157209/pdf/tropicalmed-05-00040.pdf
- Bharat Biotech International Ltd, [Revised on Aug 2018] [Accessed on 22nd May 2023], https://www.bharatbiotech.com/images/indirab/Indirab-Package-Insert.pdf
- AbhayRIG, [Accessed on 22nd May 2023], https://www.cphi-online.com/46/resourcefile/09/72/83/IIL%20Human%20Health%20Vaccine%20Brochure.pdf
- KD Tripathi, Vaccines, Antisera and lmmuneglobulins, Essentials of Medical Pharmacology, 8th Edition, 2019, 978-986.
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.