This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Rabeprazole and itopride contain the active component Rabeprazole and itopride. It is a prescription medication and should only be taken under the supervision and guidance of a healthcare professional. Rabeprazole is a proton pump inhibitor (PPI) that reduces the production of stomach acid. It is commonly prescribed for conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and conditions associated with excessive stomach acid production. Itopride, on the other hand, is a prokinetic agent that enhances gastrointestinal motility. It is primarily used to treat symptoms of functional dyspepsia, characterized by chronic or recurrent pain or discomfort in the upper abdomen, bloating, and early satiety. The FDA initially approved Rabeprazole on August 19, 1999.

Mechanism of Action of undefined

Rabeprazole and itopride can provide comprehensive therapeutic effects for certain gastrointestinal conditions. Rabeprazole, a proton pump inhibitor, helps reduce the production of stomach acid, relieving symptoms associated with excessive acid production, such as heartburn, acid reflux, and stomach ulcers. On the other hand, itopride, a prokinetic agent, enhances gastrointestinal motility, aiding in emptying the stomach and alleviating symptoms like bloating, discomfort, and early satiety. When used together, these medications can offer a synergistic effect, addressing both acid-related symptoms and impaired motility commonly seen in conditions like functional dyspepsia.

Uses of undefined

Rabeprazole and itopride treat functional dyspepsia, gastroesophageal reflux disease, and peptic ulcer.

undefined Drug administaration and Dosage available

A healthcare provider typically prescribes Rabeprazole and Itopride. This medication is usually taken orally once a day, with or without food. Use recommended dosage, which may vary depending on the specific product and individual needs. It is important to adhere to the suggested frequency and timing of the intake.

Warnings, Precautions and Side Effects of undefined


When using rabeprazole and itopride, it is important to be aware of certain warnings. Prolonged use may increase the risk of side effects such as bone fractures, magnesium deficiency, and increased susceptibility to infections like Clostridium difficile-associated diarrhea. It also leads to extrapyramidal symptoms, which are movement disorders, and caution should be exercised in patients with Parkinson's or a history of movement disorders. Additionally, rabeprazole may lead to hypomagnesemia and low vitamin B12 levels, while itopride should be used cautiously in individuals with hepatic impairment.


This medication should be used cautiously in individuals with Parkinson's disease and avoided in gastrointestinal bleeding or obstruction cases. It can also interact with certain medications, potentially leading to serious side effects. Discussing these warnings and any specific concerns with your healthcare provider before using ranitidine or domperidone is important.

Side Effects

Rabeprazole and itopride can cause side effects. Common side effects may include headache, nausea, diarrhea, abdominal pain, and constipation. It commonly causes side effects such as diarrhea, abdominal pain, nausea, and headache. Serious but rare side effects may include allergic reactions, severe skin reactions, and changes in liver function.

Word Of Advice

Regarding your health and medication usage, it is important to prioritize open communication with your healthcare provider. Make sure to provide them with a comprehensive overview of your medical history, including any existing conditions, medications you are currently taking, or any allergies you may have. Prolonged use requires monitoring for potential side effects such as bone fractures, magnesium deficiency, and an increased risk of certain infections like Clostridium difficile-associated diarrhea. Breastfeeding and pregnant women should discuss this with their healthcare provider before using it. 

It should be used cautiously in individuals with Parkinson's disease and avoided in gastrointestinal bleeding or obstruction cases. Monitor certain parameters like magnesium levels or liver function during treatment. Follow the doctor's instructions regarding dosage, frequency, and duration of medication use. If you experience any unexpected or concerning symptoms while taking Rabeprazole, itopride, or any other medications, don't hesitate to contact your healthcare provider for guidance.

Frequently Asked Question


  1. Eisai Ltd, Electronic medicines compendium (EMC), [Revised on 23 Dec 2022], [Accessed on 3rd June 2023],
  2. Eisai Ltd, US Food and Drug Administration, [Revised on Dec 2014],[Accessed on 3rd June 2023],


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.