Uses of undefined

Raltegravir is approved by the FDA for the following:

• Treatment of HIV-1 infection in adults and children aged 4 weeks and older, weighing at least 3 kg
• Used in combination with other antiretroviral drugs
• Effective for both treatment-naïve and treatment-experienced patients

undefined Drug administaration and Dosage available

Raltegravir is taken by mouth and comes in tablet, chewable tablet, and oral suspension forms. The dosage depends on the patient’s age, weight, and specific medical needs. Adults are typically prescribed 400 mg twice daily or a 1200 mg once-daily dose. For children, the dose is adjusted according to body weight. It's important to follow the dosing schedule consistently and never skip doses, as doing so can affect treatment success.

Warnings, Precautions and Side Effects of undefined

Warnings

• Do not use with aluminium or magnesium-containing antacids as they reduce its effectiveness.
• Avoid combining with rifampin, as it can lower drug levels in the body.
• Use cautiously in people with a history of depression or mental illness.
• Not recommended in individuals with severe liver disease unless closely monitored.
• It may interact with warfarin and other blood thinners, so dose adjustments may be needed.

Precautions

Before starting this medicine, inform your doctor about any history of liver problems, mental health issues, or muscle disorders. If you are pregnant or planning to become pregnant, discuss the potential risks and benefits. Breastfeeding is not recommended as HIV can be passed to the baby through breast milk. Always inform your doctor about any other medications or supplements you are taking to avoid interactions. It is also important to attend regular check-ups and lab tests to monitor liver function and viral load during treatment.

Side Effects

Common Side Effects:

• Headache
• Trouble sleeping
• Dizziness
• Nausea
• Tiredness
• Diarrhea
• Itching or rash (usually mild)

Serious Side Effects:

• Severe skin reactions (such as Stevens-Johnson syndrome)
• Liver problems (signs include yellowing of skin or eyes, dark urine)
• Muscle breakdown or weakness
• Depression or mood changes
• Allergic reactions like swelling of the face or lips

If any serious symptoms appear, medical help should be sought immediately.

Word Of Advice

For best results, take this medicine exactly as prescribed and do not stop even if you feel better. Missing doses can allow the virus to grow and become resistant. Make sure to store the tablets in a dry place away from heat and moisture. Keep a fixed schedule to avoid missing a dose, and set reminders if needed. Also, maintain a healthy lifestyle, eat a balanced diet, and stay in touch with your healthcare provider for regular updates on your treatment progress. This medicine works best as part of a complete treatment plan including other antiretroviral drugs.

Frequently Asked Question

• What is the mechanism of action of Raltegravir?
• Raltegravir works by blocking an enzyme called integrase, which HIV uses to insert its genetic material into human cells. By stopping this process, the virus cannot multiply or infect new cells. This helps reduce the amount of HIV in the body and improves immune function.

• What is the difference between Raltegravir and Dolutegravir?
• Both drugs are integrase inhibitors used to treat HIV, but Dolutegravir is newer and generally considered more potent with fewer side effects. It also has a higher barrier to resistance, meaning the virus is less likely to become resistant to it. Dolutegravir is often preferred for first-line therapy, while Raltegravir may be used in specific cases or when other drugs are not suitable.

• Is Raltegravir a PEP?
• Yes, Raltegravir can be used as part of post-exposure prophylaxis (PEP) to prevent HIV infection after a possible exposure. It is usually combined with two other antiretroviral drugs and must be started within 72 hours of exposure for maximum effectiveness. The typical duration of PEP is 28 days.

• How much does Raltegravir cost?
• In India, the cost of Raltegravir varies depending on the brand and dosage. On average, a 400 mg tablet may cost between ₹150 to ₹300 per tablet. A full month’s supply can range from ₹9,000 to ₹18,000, depending on the prescribed dose and frequency.