This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Ranitidine and Domperidone contain the active component Ranitidine and Domperidone. Ranitidine reduces stomach acid production as an H2 blocker. It can help relieve symptoms associated with conditions such as peptic ulcers, GERD, and Zollinger-Ellison syndrome. Zollinger-Ellison syndrome is a rare condition that causes excessive acid production in the stomach, leading to peptic ulcers. GERD is characterized by the backward flow of stomach acid into the esophagus, causing heartburn and acid reflux. By decreasing acid production, ranitidine can alleviate heartburn, indigestion, and stomach pain. As a dopamine receptor antagonist, Domperidone improves gastrointestinal motility and helps prevent nausea and vomiting. It is commonly used for gastroparesis, which involves delayed gastric emptying. The first FDA approval for ranitidine was granted in 1983.

Mechanism of Action of undefined

Reducing stomach acid production with ranitidine can minimize the potential irritation and discomfort caused by excess acid. Domperidone then complements the effects of ranitidine by improving gastrointestinal motility, allowing for better digestion, and preventing symptoms like nausea and vomiting.

Uses of undefined

Ranitidine and domperidone are medications with distinct uses. Ranitidine primarily treats excessive stomach acid production conditions, such as gastroesophageal reflux disease (GERD), gastric and duodenal ulcers, and Zollinger-Ellison syndrome. Domperidone is commonly prescribed for gastroesophageal reflux, functional dyspepsia, and gastroparesis.

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A healthcare provider typically prescribes Ranitidine and Domperidone. This medication is usually taken orally once a day, with or without food. Use recommended dosage, which may vary depending on the specific product and individual needs. It is important to adhere to the suggested frequency and timing of the intake.

Warnings, Precautions and Side Effects of undefined


When using ranitidine and domperidone, it is important to be aware of certain warnings. There have been concerns about potential contamination with a probable human carcinogen for ranitidine, and its use should be by guidance from regulatory authorities. Hypersensitivity reactions, including allergic reactions, can occur. Ranitidine can also interact with other medications. Domperidone has been associated with an increased risk of cardiac arrhythmias, especially in individuals with underlying heart conditions. It can cause central nervous system effects such as drowsiness and dizziness.


This medication should be used cautiously in individuals with Parkinson's disease and avoided in gastrointestinal bleeding or obstruction cases. It can also interact with certain medications and may prolong the QT interval (heart problem), potentially leading to serious irregular heart rhythms. Discussing these warnings and any specific concerns with your healthcare provider before using ranitidine or domperidone is important.

Side Effects

Ranitidine and domperidone can cause certain side effects. Common side effects of ranitidine include headache, dizziness, diarrhea, and constipation. Less frequently reported side effects include skin rash, muscle or joint pain, and changes in liver function tests. In rare cases, they may also increase the risk of cardiac arrhythmias.

Word Of Advice

Regarding your health and medication usage, it is important to prioritize open communication with your healthcare provider. Make sure to provide them with a comprehensive overview of your medical history, including any existing conditions, medications you are currently taking, or any allergies you may have. Breastfeeding and pregnant women should discuss this with their healthcare provider before using it. It should be used cautiously in individuals with Parkinson's disease and avoided in gastrointestinal bleeding or obstruction cases. Follow the doctor's instructions regarding dosage, frequency, and duration of medication use. If you experience any unexpected or concerning symptoms while taking Ranitidine, Domperidone, or any other medications, don't hesitate to contact your healthcare provider for guidance.

Frequently Asked Question


  1. Aurobindo Pharma, Electronic medicines compendium (EMC), [Revised on 15 April 2021], [Accessed on 3rd June 2023],
  2. GlaxoSmithKline, US Food and Drug Administration, [Revised on April 2009],[Accessed on 3rd June 2023],,019675s035,020251s019lbl.pdf


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.