Uses of undefined

Regorafenib has been developed to treat colon and rectum cancer, a type of stomach cancer (Gastrointestinal stromal tumour), and liver cancer (hepatocellular carcinoma) after disease progression and inadequate response to other anticancer therapies.

undefined Drug administaration and Dosage available

Regorafenib is available in the form of film-coated tablets in the dose 40mg. The usual recommended adult dose is four tablets of Regorafenib 40mg a day. Your healthcare provider will prescribe for three weeks followed by a gap of one week and adjust the dosing according to how well your body tolerates this medication. Take this tablet at the same time after a low-fat meal.

Warnings, Precautions and Side Effects of undefined

Warnings

Contact your doctor immediately if you experience shortness of breath, rapid heartbeat, infection, or severe bleeding. During the Regorafenib treatment, your doctor may periodically monitor your complete blood counts, blood sugar, electrolytes, thyroid panel, urine test (for proteinuria) and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with diabetes, hypertension, problems in your heart, liver, skin, kidneys or blood disorders. It is not recommended undergo surgical procedure while on treatment with Regorafenib Tablet due to high risk of bleeding. Tell your physician before you undergo surgery or dental procedures. Get immediate medical attention if you experience itching, vision changes, confusion or dizziness.

Precautions

Regorafenib may cause harm to an unborn baby. Tell your healthcare provider before beginning this treatment if you are pregnant or planning to have a baby. It is advised for both men and women to follow proper contraceptive methods during and eight weeks after the last dose of Regorafenib. Avoid breastfeeding your baby while you are on the treatment as Regorafenib can impact the growth and development of the baby by passing into the breast milk.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Regorafenib are high blood pressure, anaemia, thrombocytopenia, nausea, vomiting, dry mouth, diarrhoea, changes in voice, blisters, loss of appetite, fever, weight loss, constipation, rashes, hypothyroidism, dehydration, heart burn, hair loss, muscle spasms, proteinuria, weakness, etc. If you experience severe headache, chest pain, blood in cough/vomit, weakness on one side of the body, trouble speaking, or confusion, report to your doctor immediately.

Word Of Advice

Regorafenib can make you feel dizzy and weak. Avoid driving or operating heavy machines if you experience dizziness, confusion or tiredness while on treatment with Regorafenib. Drink sufficient water to prevent dehydration.

Frequently Asked Question

• What precautions should you follow while on treatment with Regorafenib?
• Do not receive vaccination or immunization without consulting your doctor while on treatment with Regorafenib.

• What tests will you undergo while on treatment with Regorafenib?
• Your healthcare provider will suggest tests to measure complete blood count, electrolytes, liver, kidney parameters, INR and blood pressure.

• Is it safe to undergo a surgery during the treatment with Regorafenib?
• Regorafenib is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and tell your physician before you undergo surgery or dental procedures. Your healthcare provider will suggest stopping the medication a day prior to surgical procedure.

• What should you do if you overdose on Regorafenib Tablet?
• If you take additional dose of Regorafenib Tablet, report to your healthcare provider right away and go to the emergency department of a hospital.

• What should you not take with Regorafenib?
• It is not recommended to take grapefruit and grapefruit juice while on treatment with Regorafenib. Tell your healthcare provider if you are taking any prescription medicines, over the counter drugs, vitamins or herbal supplements.

• When should you notify your physician?
• Get in touch with your healthcare provider immediately if you experience fever > 100˚F, infection, itching, shortness of breath, dark urine, dizziness, confusion, blood in urine or stools.

• How should you store Regorafenib?
• Store Regorafenib tablets below 30˚C, away from the reach of children.