This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Ribociclib is an anticancer medication containing the active ingredient ribociclib. Cancer is a condition in which cells multiply uncontrolled and abnormally. It is used in women to treat a type of breast cancer (hormone receptor-positive, HER2-negative breast cancer) that is locally advanced or has spread to other parts of the body. This medication is given in combination with other medications. It can also be used to treat endometrial cancer in combination with other drugs. It works by inhibiting the activity of certain proteins, which regulate cell growth and division. By blocking these proteins, it can slow down or stop the growth of cancer cells. It is not recommended for adolescents and children under 18 years of age.
Ribociclib was developed by Novartis Pharmaceuticals and was approved by the U.S. Food and Drug Administration (FDA) on 13 March 2017. It was initially approved for use in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor-positive, HER2-negative advanced, or metastatic breast cancer. Before taking this medication, it is vital to inform your doctor if you have any signs of infections (fever, mouth ulcers, or sore throat), liver disorders, heart disorders, or if you are allergic to peanut or soya. You should not drink grapefruit juice or eat grapefruits during the treatment with this tablet. It should not be used in persons with a known hypersensitivity or allergy to Kryxana 200 mg Tablet or any of its components.
Mechanism of Action of undefined
Ribociclib works by inhibiting the activity of two proteins called CDK4 and CDK6, which regulate cell growth and division. By blocking these proteins, Ribociclib can slow down or stop the growth of cancer cells.
Uses of undefined
Ribociclib is a medication used to treat certain types of breast cancer. Ribociclib is used in combination with other anticancer medications to treat advanced or metastatic (cancer that can spread to other regions of the body) breast cancer. It can also be used in combination with fulvestrant for women who have gone through menopause and have metastatic breast cancer.
undefined Drug administaration and Dosage available
Ribociclib is usually taken orally, with or without food. The tablets should be swallowed whole with a glass of water and not crushed, chewed or broken. The dosage and frequency of Ribociclib will depend on a variety of factors, including the patient's age, weight, overall health, and the type and stage of cancer being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first.
Warnings, Precautions and Side Effects of undefined
Ribociclib comes with several warnings and precautions that patients and healthcare providers should be aware of. It can harm a developing foetus or nursing infant. It can cause liver damage or dysfunction, so it is important to monitor liver function regularly during treatment. It can cause diarrhoea, which can lead to dehydration and electrolyte imbalances. It can also suppress the immune system, increasing the risk of infections.
To ensure the safe use of Ribociclib, patients should inform their healthcare provider of any medical conditions they have, disclose all medications they are taking, avoid exposure to sunlight and tanning beds, use sunscreen and wear protective clothing when outdoors, and stay hydrated by drinking plenty of fluids. You should not drink grapefruit juice or eat grapefruits during the treatment with this Tablet. Pregnancy and breastfeeding should be avoided during treatment with this medication can it can cause harm to developing foetus. It is important to follow these precautions to reduce the risk of potential side effects and to ensure that it is effective in treating the intended condition. It can interact with other medications, so it is important to inform your healthcare provider about all your medications, supplements, and herbal products.
Ribociclib can cause several side effects, which may vary in severity from person to person. Some common side effects include fatigue, nausea, vomiting, diarrhea, decreased appetite, and hair loss. Other possible side effects may include low white blood cell count, infections, fever, headache, dizziness, and abnormal heart rhythm. In rare cases, it may cause severe allergic reactions or liver damage.
Word Of Advice
Suppose you have been prescribed Ribociclib or any other medication. In that case, it is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly. It can cause serious side effects, so it is important to monitor your symptoms and seek medical attention if you experience any concerning changes in your health. It is also important to avoid alcohol and to follow any safety recommendations provided by your healthcare provider while taking it. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure that your treatment is effective and any side effects are managed appropriately. With proper monitoring and management, Ribociclib can be an effective treatment option for certain types of cancer. If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It is important not to take a double dose of Ribociclib to make up for a missed dose. It is recommended to avoid pregnancy and breastfeeding while taking this medication is important. Use effective birth control during treatment and for at least 3 weeks after the last dose. Stay hydrated and reporting any immediate reaction or symptoms to your healthcare provider is important.
Frequently Asked Question
- Novartis Pharmaceuticals UK Ltd, Electronic medicines compendium (emc), [Revised on 18 Jan 2023], [Accessed on 29th March 2023], https://www.medicines.org.uk/emc/product/8110/smpc
- Novartis Pharmaceuticals, U. S National Library of Medicine, [ Revised on Dec 2022] [Accessed on 28th March 2023], https://clinicaltrials.gov/ct2/show/NCT03701334
- Novartis Pharmaceuticals Corporation, U.S. Food and Drug Administration. Highlights of Prescribing Information: Ribociclib. [Last revised 2017], [Accessed on 29th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209092s000lbl.pdf
- Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A. Rosenberg, Cancer Chemotherapy: Principles and Practice Authors, 10th Edition, 2020, 993-994
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.