This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Rituximab is an immunomodulatory monoclonal antibody (a protein that attaches to a specific target) that was approved for its medical use on 26th November 1997.

Mechanism of Action of undefined

Rituximab Injection is a biological agent that belongs to the category of medications called monoclonal antibodies. It specifically targets and binds to the CD20 receptors, resulting in a significant decrease in the inflammatory mediators. The medicine inhibits the availability of B cells by depleting them and eventually stops the growth and multiplication of cancer cells.

Uses of undefined

Rituximab Injection has been developed to treat non-Hodgkin’s lymphoma, mature B-cell acute leukemia, chronic lymphocytic leukemia, granulomatosis, rheumatoid arthritis, and pemphigus vulgaris in patients who have not responded adequately to other treatments.

undefined Drug administaration and Dosage available

Rituximab is available as a single-use vial of injection intended for administration as an intravenous infusion. It is available in doses of 100mg and 500mg. The usual recommended starting dose is 375mg/m2. Your doctor will decide the dose, dosage, and duration of the treatment based on your medical condition. 

Warnings, Precautions and Side Effects of undefined


Contact your physician immediately if you experience severe stomach pain, allergic reactions, or any signs of a new infection. Rituximab is not recommended if you are allergic to any of its ingredients. During this treatment, your physician may monitor your heart, liver, blood, and kidney functions to prevent serious complications. Exercise caution while receiving this Injection if you have been diagnosed with HIV, active or latent tuberculosis, hepatitis B or C. Inform your health care provider if you are about to undergo any dental or surgical procedures while on treatment with this Injection. Seek immediate medical attention if you experience confusion, vision trouble, loss of balance, dizziness, or weakness on one side of your body.


Rituximab can affect the fertility of males and females. Ask your healthcare provider for advice if you are pregnant, think you might be pregnant, planning to have a baby, or breastfeeding your baby. It is probably unsafe during pregnancy it has the ability to cross the placental barrier and harm an unborn baby. It is mostly unsafe to breastfeed while on treatment with this injection. Discuss with your healthcare provider and either discontinue the treatment with this medicine or discontinue breastfeeding while on treatment with this injection. Discuss effective contraceptive methods with your healthcare provider and consider using them for 12 months after the last dose of Rituximab.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Rituximab Injection are infusion-related reactions, fever, lymphopenia, chills, infection, asthenia, upper respiratory tract infection, muscle spasms, headache, nausea, diarrhea, bronchitis, depression and changes in liver enzyme values. If you experience sickness, infection, blisters, or allergies during this treatment, report to your doctor immediately.

Word Of Advice

Check with your healthcare provider before receiving any vaccines and inform them if you are taking any other medications or herbal supplements.

Frequently Asked Question


  1. Genentech Inc., U.S. Food and Drug Administration, [Revised on Dec 2021] [Accessed on 15th Oct 2022],
  2. Ahmed A. Negm & Daniel E. Furst, Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 642-666.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.