This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Rivastigmine is an acetylcholinesterase inhibitor which was approved for its medical use in 2000.
Mechanism of Action of undefined
Rivastigmine is a biological agent that is indicated to treat mild to moderate dementia caused by Alzheimer’s or Parkinson’s. It is classified as an acetylcholinesterase inhibitor. Acetylcholinesterase and butyrylcholinesterase are two breakdown enzymes of the neurotransmitter acetylcholine. In dementia, the neurotransmitter acetylcholine levels drop in the brain due to death of nerve cells. Rivastigmine blocks the breakdown enzymes acetylcholinesterase and butyrylcholinesterase to maintain the levels of acetylcholine and ultimately reduces the symptoms of dementia.
Uses of undefined
Rivastigmine has been developed to treat mild to moderate dementia in adults with either Alzheimer’s or Parkinson’s disease.
undefined Drug administaration and Dosage available
Rivastigmine is available in the form of capsules, oral solution and transdermal patches. Your healthcare provider will tell you which dosage form and dose to take depending on your health condition. The starting dose is 1.5mg twice a day for oral solution and capsule.
The transdermal patches are available in the doses 4.6 mg/24 h, 9.5 mg/24 h and 13.3 mg/24 h. Take the previous patch before using the new one. Use only one patch a day and do not cut them into pieces. Ensure that your skin is clean and dry before using a patch.
Warnings, Precautions and Side Effects of undefined
Discuss with your healthcare provider if you have or had irregular heartbeat, heart problems, stomach ulcer, difficulty passing urine, seizures, asthma, problem with liver or kidneys. Your healthcare provider will monitor you closely to prevent complications.
Tell your healthcare provider if you are pregnant, breastfeeding or planning to have a baby. Your healthcare provider will prescribe Rivastigmine only if it is necessary for you.
The most common side effects that are likely to occur with Rivastigmine treatment are nausea, vomiting, loss of appetite, asthenia, etc. People taking Rivastigmine oral solution are more likely to experience anxiety, sweating, headache, heartburn, stomach pain, weight loss, agitation, tiredness, weakness, confusion and nightmares. Loss of appetite, dizziness, agitation and urinary incontinence are more common among people using Rivastigmine patch.
Word Of Advice
Rivastigmine can cause dizziness and confusion, hence it is advisable to avoid driving or using machines during this treatment. If you are using a patch, make sure that you do not expose it to excessive heat for long periods of time.
Frequently Asked Question
- Novartis Pharmaceuticals UK Ltd., Electronic Medicines Compendium (EMC), [Revised on Nov 2020] [Accessed on 10th Aug 2022], https://www.medicines.org.uk/emc/files/pil.7764.pdf
- Rosemont Pharmaceuticals Ltd., Electronic Medicines Compendium (EMC), [Revised on Sep 2019] [Accessed on 10th Aug 2022], https://www.medicines.org.uk/emc/files/pil.6903.pdf
- Novartis Pharmaceuticals Ltd., Electronic Medicines Compendium (EMC), [Revised on Dec 2018] [Accessed on 10th Aug 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020823s036,021025s024lbl.pdf
- Serge Gauthier et al., Real-life effectiveness and tolerability of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer's disease: the EMBRACE study, Curr Med Res Opin, 2013 Aug;29(8):989-1000, https://pubmed.ncbi.nlm.nih.gov/23647369/
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.