This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Rizatriptan was initially approved by the United States Food and Drug Administration (FDA) on June 29, 1998.

Mechanism of Action of undefined

Rizatriptan binds to serotonin receptors (5-HT1B/1D receptors) in the brain's blood vessels. This causes vasoconstriction (narrowing of blood vessels) and reduces the release of certain chemicals that contribute to the inflammation and pain associated with migraines.

Uses of undefined

Rizatriptan is primarily utilized to treat acute migraine headaches. This medication helps relieve the pain, nausea, and sensitivity to light and sound associated with migraines, offering relief during the onset of migraine attacks.

undefined Drug administaration and Dosage available

Rizatriptan is available in various forms, including orally disintegrating tablets, standard tablets, and orally dissolving wafers. The medication is usually taken as soon as migraine symptoms appear. It is important to follow the dosing instructions the prescribing healthcare professional provides.

Warnings, Precautions and Side Effects of undefined


Serious cardiovascular events such as heart attacks and strokes are potential risks associated with its use. Although rare, allergic reactions could occur, showing symptoms like hives or difficulty breathing. Interactions with certain medications might trigger serotonin syndrome, a serious condition. Dizziness and drowsiness are common side effects, impacting activities like driving or operating machinery. Pregnant or breastfeeding individuals should exercise caution due to potential risks. 


Before taking Rizatriptan, inform your healthcare provider about your complete medical history, including cardiovascular issues, hypertension, liver problems, and migraines. Be aware of potential allergic reactions and seek medical attention promptly if any occur. Discuss potential interactions with other medications, particularly antidepressants or other migraine drugs. Be cautious about driving or using machinery if you experience dizziness or drowsiness. Pregnant or breastfeeding individuals should consult healthcare providers before using it.

Side Effects

Rizatriptan can lead to side effects, including common ones such as dizziness, drowsiness, nausea, fatigue, and a sensation of warmth or tingling. More serious side effects encompass cardiovascular events, chest pain, changes in heart rate, high blood pressure, and the potential for allergic reactions. Additionally, there's a rare risk of serotonin syndrome.

Word Of Advice

Blood pressure should be monitored during treatment with Rizatriptan. Inform your healthcare provider about your complete medical history, especially if you have a history of cardiovascular diseases, high blood pressure, liver problems, kidney problems, epilepsy, or certain headaches. Inform them of any other allergies you may have.  Take this medication as soon as migraine symptoms begin. Its effectiveness is generally higher when taken early during an attack. If you have a history of gastrointestinal disorders, such as gastroparesis, consult your healthcare provider before using this medication. This medication might cause warmth or tingling sensations, potentially affecting light sensitivity. Be cautious in bright environments.

Frequently Asked Question


  1. Glenmark Pharmaceuticals Europe Limited, Electronic Medicines Compendium (EMC), [Revised on 10th Jun 2021] [Accessed on 26th Aug 2023],
  2. J.P. Leach, R.J. Davenport, Neurological disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 1137-1230.
  3. IntelGenx Corp, US Food & Drug Administration, [Revised on 04th 2023] [Accessed on 26th Aug 2023],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.