This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Sildenafil is a phosphodiesterase-5 inhibitor which was approved for its medical use on 27th March 1998.

Mechanism of Action of undefined

Sildenafil is a medication that belongs to the category of phosphodiesterase-5 inhibitors. it mimics cyclic guanosine monophosphate (cGMP) and protects cGMP from degradation. Adequate cGMP levels enhance protein kinase activity and relaxation of smooth muscles, which improves blood flow.

Uses of undefined

Sildenafil is indicated to treat erectile dysfunction and pulmonary arterial hypertension. It increases exercise capacity in patients diagnosed with pulmonary arterial hypertension.

undefined Drug administaration and Dosage available

Sildenafil is available as tablets in the doses 50mg and 100mg, injection in the dose 10mg and as a 5gm oral suspension. Your healthcare provider will administer the injection as an intravenous bolus three times a day. The tablet and oral suspension are recommended three times a day, 4-6 hours apart.

Warnings, Precautions and Side Effects of undefined


Sildenafil is not recommended for people who are hypersensitive to Sildenafil or its ingredients. Your healthcare provider will monitor your blood pressure, heart function, liver and kidney parameters to prevent complications. Tell your healthcare provider if you have been diagnosed with heart problems, sickle cell anaemia, vision problems, stomach ulcer, or pulmonary veno-occlusive disease. Seek immediate medical attention if you experience sudden loss of vision or hearing.


Sildenafil is not recommended for use during pregnancy as it has the tendency to cause fetal harm. Tell your physician before starting this treatment if you are pregnant or planning to get pregnant. It is not known if Sildenafil passes into the breast milk. If you are a breastfeeding mother, your health care provider will suggest whether to discontinue breastfeeding or discontinue this treatment based on your condition.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Sildenafil are headache, dyspepsia, flushing, insomnia, erythema, breathlessness and rhinitis. If you experience any allergic reactions after taking this medicine, report to your healthcare provider immediately.

Word Of Advice

Eat a well-balanced diet and consume plenty of water to maintain hydration. Monitor your blood pressure at regular intervals.

Frequently Asked Question


  1. Pfizer Ltd., [Revised on Feb 2020] [Accessed on 11th Oct 2022],
  2. Smith BP, Babos M. Sildenafil, [Updated 2022 May 3], In: StatPearls [Internet], [Accessed on 11th Oct 2022],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.