This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Somatrogon is a long-acting recombinant human growth hormone (GH) analogue developed to address growth hormone deficiencies. It was approved by the U.S. FDA on January 21, 2022. Somatrogon, marketed under the name Ngenla, offers a more convenient weekly administration compared to daily injections of traditional growth hormone therapies.

Mechanism of Action of undefined

Somatrogon acts by stimulating the growth hormone receptors in target tissues, promoting the release of insulin-like growth factor 1 (IGF-1). IGF-1 subsequently stimulates growth in various tissues, aiding in bone and muscle development while also regulating metabolism, enhancing protein synthesis, and reducing fat stores.

Uses of undefined

Somatrogon is primarily used to treat pediatric patients with growth hormone deficiency (GHD), a condition where the body cannot produce adequate amounts of growth hormone. It helps promote normal growth in children with short stature due to insufficient GH levels.

undefined Drug administaration and Dosage available

Somatrogon is administered as a subcutaneous injection, typically once a week. The dosage is individualised based on patient weight and treatment response. It is available in prefilled pens with different dose strengths, allowing flexible dosing for pediatric patients.

Warnings, Precautions and Side Effects of undefined

Warnings

Somatrogon use may increase the risk of developing serious side effects like intracranial hypertension, glucose intolerance, and impaired glucose control. Patients with active malignancy, acute critical illness, or those with closed epiphyses should avoid the drug. Close monitoring is required during treatment.

Precautions

Before starting Somatrogon, patients should be screened for hypothyroidism, as it can affect their response to the therapy. Due to potential effects on glucose metabolism, regular monitoring of blood sugar levels is advised. Patients with pre-existing conditions like scoliosis may experience worsening symptoms.

Side Effects

Common side effects of Somatrogon include injection site reactions, headaches, and gastrointestinal disturbances like nausea or vomiting. More severe adverse reactions may include hyperglycemia, joint pain, and, in rare cases, an elevated risk of malignancy or cardiovascular issues.

Word Of Advice

Patients and caregivers should closely follow the prescribed dosage and administration schedule. Regular monitoring of growth and IGF-1 levels is important to assess treatment efficacy. If severe side effects occur, such as persistent headaches or changes in vision, consult your healthcare provider immediately.

Frequently Asked Question

Disclaimer

This information is for educational purposes only. Always consult a doctor before starting any new medicine or therapy.