This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Tacrolimus is an immunosuppressant that was approved for its medical use on 8th April 1994.

Mechanism of Action of undefined

Tacrolimus is an immunosuppressant that prevents organ rejection in organ transplantation. It is classified as an immunosuppressant belonging to the category of Calcineurin inhibitors. Tacrolimus works by binding to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response. Tacrolimus is often prescribed along with other immunosuppressants like azathioprine and mycophenolate mofetil.

Uses of undefined

Tacrolimus has been developed to prevent organ rejection in adult and pediatric patients receiving an allogeneic transplant of the liver, kidney, heart, or lung.

undefined Drug administaration and Dosage available

Tacrolimus is available in the form of capsules, injections, oral suspensions, and ointments. Tacrolimus Capsule is available in doses 0.5mg, 1mg, and 5mg. your healthcare provider will administer Tacrolimus Injection (5mg/ml) if you are unable to tolerate an oral capsule or suspension. Your healthcare provider will prescribe the accurate dose based on the organ transplanted, body weight, and health condition. Patients diagnosed with cystic fibrosis might require higher doses.

Warnings, Precautions and Side Effects of undefined


Contact your doctor immediately if you experience fever, lightheadedness, or breathing difficulty. During the Tacrolimus treatment, your doctor may periodically monitor your complete blood count, blood pressure, blood sugar, electrolytes and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with blood disorders (pure red cell aplasia), diabetes, hypertension, and heart and kidney problems. Avoid receiving live vaccines during this treatment. 


Tacrolimus has the ability to cause fetal harm, so it is advisable to tell your physician if you are pregnant or planning to have a baby. This medicine also has the tendency to increase blood pressure and blood sugar levels in pregnant women. Avoid breastfeeding your baby while you are on the treatment as Tacrolimus can impact the growth and development of the baby by passing into the breast milk. Discuss effective contraceptive options with your healthcare provider before starting this treatment to prevent unwanted pregnancy.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Tacrolimus are abnormal kidney function, hypertension, diabetes mellitus, fever, CMV infection, tremor, high blood glucose levels, leukopenia, infection, anemia, bronchitis, pericardial effusion, urinary tract infection, constipation, diarrhea, headache, stomach pain, insomnia, paraesthesia, nausea, high levels of blood cholesterol, potassium and magnesium. If you experience any allergic reactions such as excessive sweating, chest pain, or tremors report them to your doctor immediately.

Word Of Advice

Tacrolimus can make your skin sensitive. Apply sunscreen with a good SPF and wear protective clothing before you step out in the sun. Tell your healthcare provider before starting this treatment if you have been diagnosed with lactose intolerance.

Frequently Asked Question


1. Astellas Pharma, [Revised on Aug 2021] [Accessed on 5th Sep 2022],

2. Alan M. Krensky, Jamil R. Azzi, and David A. Hafler, Goodman & Gilman’s Pharmacological Basis of Therapeutics, Immunosuppressants and Tolerogens, 13th Edition, 2018, 637-653.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.