This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

 Telmisartan, metoprolol, and cilnidipine is a combination medication and was approved for medical use which helps in controlling high blood pressure. It belongs to the class of antihypertensive drugs.

Mechanism of Action of undefined

The combination medication Telmisartan, metoprolol, and cilnidipine works by relaxing the blood vessels and making the heart pumping action efficient when single or dual drug therapy is ineffective. functions by preventing angiotensin II from attaching to its receptors.  By blocking these receptors, telmisartan stops angiotensin II vasoconstriction and aldosterone-releasing activities, causing blood vessels to widen and blood pressure to drop. Metoprolol is a beta blocker; it slows down the heart rate. Clonidine lowers the sympathetic outflow from the central nervous system, which lowers blood pressure, heart rate, and peripheral vascular resistance.

Uses of undefined

 Telmisartan, metoprolol, and cilnidipine are used for hypertension. This medication is recommended when single or dual therapy is not effective. It helps relax the blood vessels by making it easier for the heart to pump blood all over the body, and it lowers the risk of heart attack and stroke.

undefined Drug administaration and Dosage available

Telmisartan, metoprolol, and cilnidipine combination is available in oral dosage tablet form containing telmisartan 40 mg, cilnidipine 10 chew, crush succinate 23.75 mg. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. It should be consumed as a whole not to chew,crush or bite.

Warnings, Precautions and Side Effects of undefined

Warnings

Stopping this medication without proper advice will make the condition worse. It acts by lowering blood pressure and reduces the risk of heart attack and stroke, so don't stop this medication without the proper advice of a doctor.It may cause hypotension and renal impairment, clonidine may lead to severe hypotension and rebound hypertension if discontinued abruptly, and metoprolol may result in bradycardia and bronchospasm. Carefully monitor these side effects and report if you find any discomforts to your physician.

Precautions

Before starting the Telmisartan, metoprolol, and cilnidipine therapy inform your doctor about any kidney or liver-related problems. If you are a breastfeeding mother or planning for pregnancy, you need to inform your doctor before starting this medication. While using this medication, blood pressure should be monitored regularly, and a kidney function test should be performed to note if there are any abnormal changes.

Side Effects

Telmisartan, metoprolol, and cilnidipine can cause side effects like any other medicine. Sometimes it may cause some serious side effects that include swelling of ankles and feet, slow heart rate and hypotension and commonly, people may experience fever, increased potassium levels, tiredness, feeling sleepy, headaches, back pain, difficulty in breathing, stomach upset and nausea. 

Word Of Advice

 It is suggested to tell your doctor if there is any history of allergic reactions to avoid life-threatening complications. As it causes an increase in potassium, avoid taking potassium content in diet and potassium supplements. Tell your doctor before the treatment commencement if you are pregnant or having liver, kidney, or uterine problems. While using this medication, blood pressure should be monitored regularly, and a kidney function test should be performed to note if there are any abnormal changes.

Frequently Asked Question

References

 Boehringer Ingelheim Pharmaceuticals, Inc, Electronic medicines compendium (EMC), [Revised on March 2022) [Accessed date 4/11/2022] https://www.medicines.org.uk/emc/files/pil.3164.pdf 

2.  KD. Tripathi. Antianginal and Other Anti-ischemic Drugs & Drugs Affecting Renin-Angiotensin System. Eighth edition. June 2018, 596 & 536.

3. Torrent Pharmaceuticals Ltd. Telstar N (Telmisartan and Cilnidipine Tablets), [Revised in April 2020], [Accessed on 24/06/2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2909.pdF  
4. Boehringer Ingelheim Pharmaceuticals, Inc, US Food & Drug Administration, [Revised on 3/5/2011], [Accessed on 24/06/2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/ 2004/020850s011lbl.pdf 

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.