This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Torasemide is an antidiuretic drug that belongs to the category of medicines known as loop diuretics. It was approved by the U.S. FDA in 1993 to treat hypertension and oedema.

Mechanism of Action of undefined

Torsemide inhibits the Na+/K+/2Cl- co-transporter (NKCC2) in the thick ascending limb of the loop of Henle. By blocking this transporter, it reduces the reabsorption of sodium, potassium, and chloride, increasing their concentration in the urine and promoting water excretion. 

Its diuretic effect depends on how much the body excretes in the urine rather than its blood concentration. Torsemide does not significantly affect glomerular filtration rate (GFR), renal plasma flow (RPF), or acid-base balance.

Uses of undefined

Torasemide is used in the treatment of hypertension (patients with high blood pressure). It is also used to treat low potassium levels in the body, otherwise known as hypokalemia. It is indicated in adults for the treatment of oedema associated with heart failure or renal disease.

undefined Drug administaration and Dosage available

Take this medication as directed by your doctor. It is best to take it in the morning to help avoid frequent urination at night. Try to take it at the same time each day. Do not break or chew the tablet; swallow it whole with a glass of water.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Risk of hypotension and renal dysfunction: Excessive diuresis can cause dehydration, hypotension, and worsening renal function, especially in salt-depleted patients or those using renin-angiotensin-aldosterone inhibitors. Monitor for signs of dehydration or low blood pressure.
  • Older adults and renal impairment: Use torsemide cautiously in older adults or patients with severe renal impairment, as they require close monitoring of renal function. 
  • Electrolyte imbalances: Torsemide can lower levels of potassium, sodium, magnesium, calcium, and chloride. Regularly monitor electrolytes during treatment. 
  • Ototoxicity: Higher doses or renal impairment may increase the risk of tinnitus and hearing loss. Contact your healthcare provider if you notice any changes in hearing.
  • Hyperglycemia and gout: Torsemide can raise blood glucose and uric acid levels, potentially triggering gout. Monitor blood glucose and uric acid levels, especially in patients with diabetes or a history of gout.

Precautions

Before starting torsemide, tell your doctor if you have active bleeding, a history of kidney problems, or any conditions that may affect renal function. Torsemide can cause electrolyte imbalances and dehydration, so stay hydrated and report symptoms like weakness or dizziness. Always inform your healthcare provider about all other medications you’re taking, mainly those that could interact with torsemide, like diuretics or ACE inhibitors. Use torsemide during pregnancy only if necessary, and avoid it while breastfeeding. Regular follow-up visits are important to monitor kidney function, electrolytes, and blood glucose levels.

Side Effects

Common side effects of Torsemide may include:

  • Stomach pain
  • Headache
  • Dizziness
  • Leg cramps
  • Hair loss
  • Nausea and vomiting

Serious side effects of Torsemide may include:

  • Irregular heartbeat
  • Skin rash
  • Breast pain
     

If you experience any allergic or unusual reactions, contact your doctor immediately.

Word Of Advice

You should inform your doctor if you have a history of allergic reactions to prevent potentially life-threatening complications. Take torsemide in the morning to avoid frequent urination during the night. Before starting treatment, tell your doctor if you are pregnant or have any heart, liver, kidney, or uterine conditions, and provide details of any other medications you are taking, as they may interact with torsemide. While on this medication, regular monitoring of kidney function, blood pressure, and potassium levels is recommended.

Frequently Asked Question

References

  1. DEMADEX (torsemide) tablets (Revised on August 8, 2022). Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020136s014lbl.pdf (Accessed on May 12, 2023).
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213218s000lbl.pdf
  3. Bioequivalence Study of Two Formulations of Torasemide Tablet 10 mg. (Revised on June 10, 2021). Available at:https://clinicaltrials.gov/ct2/show/NCT04921566  (Accessed on May 12, 2023).
  4. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Hypertension. Pharmacotherapy Handbook. Ninth edition. Page-87.

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.