Uses of undefined

Trabectedin is an intravenously administered drug.  It is used to treat liposarcoma (a type of cancer that starts in fat cells) or leiomyosarcoma (cancer that begins in smooth muscle tissue) that has spread to other parts of the body and cannot be treated with surgery in individuals who have already received treatment with certain anti-cancer medications. It is also indicated to treat ovarian cancer that has reoccurred after at least 1 previous therapy and not responding to other treatments. 

undefined Drug administaration and Dosage available

Trabectedin is available as 1mg injection. It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. Your doctor will give you certain medications to lessen the chance of getting side effects from the Trabectedin treatment.  

Warnings, Precautions and Side Effects of undefined

Warnings

This drug is intended to cause a severe decrease in white blood cell counts. Monitor complete blood count and other laboratory parameters regularly. Rhabdomyolysis (muscle tissue breakdown) may occur with this medicine; inform your physician if you experience any symptoms of muscle pain and other symptoms. This medicine may cause liver toxicity, and cardiac problems on long-term use.  This medicine should not be given during pregnancy because it can cause severe birth defects. 

Precautions

Inform your physician if you have an active infection or have suffered from any infections, liver disease, kidney problems, or heart diseases. This medicine may impair fertility; discuss with your doctor before planning for pregnancy. Do not take Trabectedin if you are allergic to Trabectedin or any other ingredients of this medicine, if you have serious infections, if you are breastfeeding, and if you will receive a yellow fever vaccine. Report to your physician if you face any symptoms of sudden difficulty in breathing, fever, redness or flushing of the skin, or a rash, nausea, or vomiting after administering the injection. Trabectedin is not recommended for children and young people under 18 years of age. Use an effective method of contraception while being treated with this injection. Avoid pregnancy and breastfeeding during the treatment.

Side Effects

The common side effects of trabectedin include constipation, decrease in appetite, diarrhea, nausea, vomiting, anemia, decreased albumin levels, decreased platelet count, headache, shortness of breath, tiredness. Other serious side effects of trabectedin include heart problems, skin rashes, liver problems, and severe muscle pain. 

Word Of Advice

Store Trabectedin in the refrigerator (2°C to 8°C). Do not freeze. Keep the injection away from the reach of children and pets. If you have missed any dosing appointments, inform your doctor and schedule immediately. Trabectedin may interfere with vaccines, inform your physician before taking yellow fever vaccine or any other vaccines. This injection may cause severe birth defects if taken during pregnancy. Female patients with reproductive potential should use effective contraception during the treatment. Male patients with female partners with reproductive potential should use effective birth control methods during the treatment and for at least 5 months after their last dose. Do not breastfeed during treatment with this injection. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy. 

Frequently Asked Question

• Can Trabectedin cause hair loss?
• Yes, Trabectedin can cause hair loss, although it is not a common side effect. Hair loss is usually temporary, and hair will grow back once treatment is completed.

• Can Trabectedin cause fertility problems?
• Yes, Trabectedin can cause fertility problems in both men and women. Men may experience decreased sperm count and quality, while women may experience irregular menstrual cycles or early menopause.

• Can Trabectedin be given at home?
• A healthcare professional typically administers bleomycin in a hospital or clinic setting. However, in some cases, it may be possible for patients to receive Trabectedin at home with the support of a healthcare professional.

• Can Trabectedin cause shortness of breath?
• Trabectedin can cause infusion-related reactions like shortness of breath. If you face any of these symptoms inform your doctor immediately and seek medical advice. 

• Can Trabectedin be given to patients with kidney problems?
• Trabectedin is primarily excreted through the kidneys, so patients with kidney problems may be at increased risk of side effects from the drug. Inform your physician if you have kidney problems before initiating the therapy.