This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Ulinastatin contains an active component as Ulinastatin. It is also known as a urinary trypsin inhibitor (UTI). It is a medication used in some countries for its anti-inflammatory and immunomodulatory effects. It was initially isolated from human urine and has been studied for potential therapeutic benefits. 

Mechanism of Action of undefined

Ulinastatin's mechanism of action involves inhibiting various proteolytic enzymes, such as trypsin and elastase, which are crucial in promoting inflammation and tissue damage. By suppressing these enzymes, this medication reduces the activation of inflammatory pathways and modulates the immune response, ultimately leading to decreased inflammation and potential mitigation of tissue injury. 

Uses of undefined

Ulinastatin treats acute pancreatitis, sepsis, and acute respiratory distress syndrome (ARDS).

undefined Drug administaration and Dosage available

Ulinastatin is administered intravenously (vein injection) under medical supervision. Your healthcare professional will determine the specific dosage and administration guidelines based on your condition and needs.

Warnings, Precautions and Side Effects of undefined


Ulinastatin's impact on patients with liver impairment is not well-established. The safety during pregnancy and breastfeeding is not fully established. intravenous administration of may lead to fluid overload, especially in patients with existing heart or kidney conditions. This medication’s immunomodulatory effects could increase the risk of infections. It may cause a decrease in platelet counts (thrombocytopenia) in some patients. It may impact on the central nervous system may cause dizziness, headache, or other neurological symptoms in some individuals. Patients with pre-existing autoimmune disorders should be closely monitored during treatment. The immunomodulatory effects of this medication may influence autoimmune conditions.


Caution is advised when using the medication in individuals with liver conditions, and close monitoring may be necessary. Pregnant or breastfeeding individuals should use the medication only if needed and under the supervision of a healthcare professional. Careful fluid management and monitoring are essential during treatment. Patients should be monitored for signs of new or worsening infections during therapy. Regular blood tests to monitor platelet levels may be necessary, especially in those with a history of bleeding disorders.

Side Effects

Ulinastatin may cause side effects, including nausea, vomiting, diarrhea, skin rashes, headache, injection site reactions, and in rare cases, severe allergic reactions or anaphylaxis; patients should seek immediate medical attention if they experience any signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, hives, or itching.

Word Of Advice

Patients with known hypersensitivity to ulinastatin or any of its components should not use the medication. Regular monitoring of kidney and liver function is essential, and dose adjustments may be necessary for patients with impaired organ function. Caution is advised in pregnant and breastfeeding individuals, and the medication should only be used if needed and under medical supervision. Close monitoring for signs of allergic reactions, infections, and changes in blood counts is recommended. Patients with a history of gastrointestinal or bleeding disorders should be closely monitored during treatment. It's important to discuss all medical conditions and medications with the healthcare provider to ensure the safe and effective use of this medication.

Frequently Asked Question


  1. Bharat Serums and Vaccines Limited, [Accessed on 27th July 2023],
  2. Qiancheng Xu et al; Ulinastatin is effective in reducing mortality for critically ill patients with sepsis: a causal mediation analysis; Scientific Reports; [Published on 25/09/2018]; [Accessed on 27/07/2023];
  3. Ling-Zhang wang et al; Effect of ulinastatin on serum inflammatory factors in Asian patients with acute pancreatitis before and after treatment: a meta-analysis; International Journal of Clinical Pharmacology and Therapeutics; [Published on Nov 2016]; [Accessed on 27/07/2023];


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.