This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Ustekinumab is a monoclonal antibody that belongs to the group of medications called interleukin inhibitors. The FDA approved this medicine for its medical use on September 24, 2013

Mechanism of Action of undefined

Ustekinumab is a monoclonal antibody that binds specifically to certain signaling proteins (interleukin-12 and interleukin-23) in the body, which is involved in inflammatory and immune responses. It works by targeting, neutralizing, and stopping the action of certain cells in the body that causes the symptoms of certain diseases. 

Uses of undefined

It treats moderate to severe plaque psoriasis (skin disease with red and scaly patches on some body areas). It is used alone or in combination with other medicines to treat active psoriatic arthritis (a condition that causes joint pain, swelling, and scales on the skin) in adults. Ustekinumab is also indicated to treat moderate to severe Crohn's disease and ulcerative colitis in adults.

undefined Drug administaration and Dosage available

Ustekinumab is available as an injection in two doses, 130mg, and 90mg. It will be given to you by a doctor or nurse in a hospital or clinic setting. It is given as an intravenous infusion (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Warnings, Precautions and Side Effects of undefined


This drug is indicated to cause serious, life-threatening allergic reactions. Inform your physician immediately if you experience sudden allergic reactions such as difficulty breathing or wheezing, swelling, rash, itching, fever, and chills. Ustekinumab may increase the risk of infections and reactivation of latent infections, including serious infections. It's important to promptly report any signs of infection to your healthcare provider, such as fever, cough, or flu-like symptoms. Do not take Ustekinumab if you are allergic to Ustekinumab or any of the other ingredients of this medicine. Do not take this medicine if you have any active infections. Do not use this medicine if you are pregnant or breastfeeding.


Inform your doctor if you recently had tuberculosis, skin diseases, allergies, or other diseases. Tell your doctor if you are taking other treatments for psoriasis or psoriatic arthritis. This medicine is not recommended for use in children under 18 years of age with Crohn's disease or ulcerative colitis. Inform your healthcare provider about all the medicines that you take, including prescription, over-the-counter, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Ustekinumab and reduce its effectiveness by causing undesirable side effects. 

Side Effects

The common side effects of Ustekinumab are swelling at the site of injection, redness in the skin, abdominal pain, diarrhea, nausea, vomiting, tiredness, headache, sore throat, back, muscle, or joint pain. Other serious side effects include severe allergic reactions (anaphylaxis), skin cancer, infections, lung inflammation and infection, and heart attack.

Word Of Advice

Store Ustekinumab in the refrigerator (2°C to 8°C). Do not freeze. Keep the injection away from the reach of children and pets. Do not shake the vials because prolonged shaking may damage the effectiveness of the medicine. If you have missed any dosing appointments, inform your doctor and schedule immediately. 

Ustekinumab may increase your risk for heart attack and strokes. Your doctor will regularly check your risk factors for heart disease and stroke to ensure that they are appropriately prevented. If you develop chest pain, weakness, or abnormal sensation on one side of your body, facial droop, or visual or speech difficulties, seek medical attention immediately. If you are a female patient with reproductive potential, use effective contraception during the treatment to avoid pregnancy.

Frequently Asked Question


  1. Janssen Biologics B.V., Electronic medicines compendium (EMC), [Revised on March 2023] [Accessed on June 21 2023]
  2. Janssen Biotech, Inc., US Food and Drug Administration [Revised on September 2016] [Accessed on June 21 2023]
  3. Cite this Page Colquhoun M, Kemp AK. Ustekinumab. [Updated 2023 March 27]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; [Accessed on June 2023]


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.