This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Zoledronic Acid is an anti-resorptive medication which was approved for its medical use on 22nd February 2002.
Mechanism of Action of undefined
Zoledronic Acid Injection is an anti-resorptive medication that belongs to the class of bisphosphonates. Zoledronic acid works by inhibiting the cell signaling pathways that produce osteoclasts. This process further inhibits bone resorption and also induces programmed cell death of cancer cells.
Uses of undefined
Zoledronic Acid Injection has been developed to treat osteoporosis and prevent bone complications in patients diagnosed with bone cancer. A condition called tumor-induced hypercalcemia is common among people diagnosed with cancer. Zoledronic acid Injection is indicated to reduce blood calcium levels in such conditions.
undefined Drug administaration and Dosage available
Zoledronic Acid Injection is available as a single-dose vial for injection in doses 4mg and 5mg. It is intended for administration as an intravenous infusion after reconstitution. Your healthcare provider will prescribe an accurate dose depending on your health condition. If you have been diagnosed with a kidney problem, your doctor will administer a lower dose.
Warnings, Precautions and Side Effects of undefined
During the Zoledronic Acid Injection treatment, your doctor may periodically monitor your blood calcium, phosphorus, and magnesium and kidney parameters to prevent serious complications. Get a dental appointment before starting treatment with Zoledronic Acid Injection. Tell your healthcare provider before starting treatment with Zoledronic Acid Injection if you have been diagnosed with hypocalcemia, a problem in your heart or kidneys, or you are undergoing chemotherapy/radiotherapy. Get immediate medical attention if you have breathlessness or allergies.
Zoledronic Acid Injection is not recommended for use during pregnancy and breastfeeding. Tell your healthcare provider before starting this treatment if you are pregnant, think you might be pregnant, breastfeeding, or planning to have a baby.
The common side effects that are likely to occur while you are on the treatment with Zoledronic Acid Injection are low levels of calcium and phosphorus, headache, flu, tiredness, weakness, drowsiness, chills, pain in the bone, joint and muscle, nausea, vomiting, conjunctivitis and anemia. If you experience any reactions like rashes, bruising, swelling, and itching at the Injection site, report to your doctor immediately.
Word Of Advice
Zoledronic Acid Injection rarely causes dizziness and sickness. However, it is advisable to avoid driving or handling machines during this treatment if you feel uncomfortable. Drink sufficient water before treatment to prevent dehydration.
Frequently Asked Question
1. KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.
2. Seacross Pharmaceuticals Ltd, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 14th Sep 2022], https://www.medicines.org.uk/emc/files/pil.7205.pdf
3. Wang, L., Fang, D., Xu, J. et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer 20, 1059, Published on 2020, [Accessed on 14th Sep 2022], https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-020-07568-9.pdf
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.