• Uremic pruritus in CKD and Hemodialysis patients
• Atopic dermatitis in CKD Patients

Koza91 lotion reduces the overactivation of mast cells, preventing excessive immune responses that cause itching. It inhibits the release of histamines, which contribute to skin irritation. Simultaneously, the solution decreases inflammatory markers and cytokines, reducing redness and swelling. It has an antinociceptive effect, acting as a pain reliever. Stimulating the skin's cold receptors creates a cooling sensation and dilates blood vessels, improving blood flow. This dual action acts as an effective analgesic and functions as a soothing coolant when applied topically. The solution addresses skin barrier function issues by boosting lipid synthesis, making the skin more resilient. It also enhances skin hydration, ensuring your skin feels nourished and moisturized.

Inform your doctor if you are taking topical medications before using Koza91 lotion solution to avoid undesirable side effects.

• Store below 25°C.
• Keep out of reach of children.
• Protect from moisture, heat, and direct sunlight.
• Do not use Koza91 lotion solution after the expiry date.

It is for external use only. Always use Koza91 lotion solution exactly as advised by your doctor. Take the required amount of the solution in your palm and apply it to the required areas as often as needed. Do not wash the application site right after applying the solution.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious

• Allergic reactions

Common

• Skin irritation
• Burning sensation
• Dryness

Before using Koza91 lotion solution, following your healthcare provider's instructions is essential. Apply the lotion as directed and avoid using more than the recommended amount. If you notice any skin irritation, redness, or itching that doesn't improve or worsen, contact your healthcare professional promptly. Additionally, be aware of any signs of allergic reactions such as rash, swelling, dizziness, or difficulty breathing; seek immediate medical help if you experience any of these symptoms. Remember to keep your skin well-moisturized, and if you have any concerns or questions about the solution, don't hesitate to discuss them with your healthcare provider.

1. La Renon Healthcare Pvt Limited, [Revised on Feb 2020] [Accessed on Oct 2023] https://www.larenon.com/wp-content/uploads/2020/02/Koza91-LBL.pdf
2. Leon Kircik; A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis; Published on April 2010; Accessed on 09/10/2023; https://pubmed.ncbi.nlm.nih.gov/20514790/
3. Elise Herro, et al., ; Mentha piperita (peppermint); Dermatitis; Published on Dec 2010; Accessed on 09/10/2023; https://pubmed.ncbi.nlm.nih.gov/21144345/