Phostat 667mg tablet is used in the following:

• Hyperphosphatemia in CKD/ESRD
• Adjunct to dietary management in CKD/ESRD dialysis

Phostat 667mg tablet's therapeutic action is its ability to bind with dietary phosphate in the gastrointestinal tract. Upon ingestion, it dissociates into calcium and acetate ions. The calcium ions form insoluble complexes with phosphate ions from ingested foods, forming calcium phosphate salts that are not absorbed into the bloodstream. As a result, phosphate absorption from the diet is reduced, leading to lower phosphate levels in the blood.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Phostat 667mg tablet, reducing effectiveness by causing undesirable side effects. 

• Should be stored at room temperature, between 20°C to 25°C.
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Phostat 667mg tablet is typically administered orally, meaning it is taken by mouth as tablets or capsules. The medication is designed to be swallowed with water and should not be chewed or crushed unless specifically instructed by a healthcare provider. The oral route is the most common and effective way to use this medication to manage hyperphosphatemia in individuals with chronic kidney and end-stage renal disease.

Phostat 667mg tablet causes some side effects like all medications, although not everyone will experience them. 

Serious:

• Hypercalcemia
• Calcium-based tissue deposition
• Aluminum toxicity

Common:

• Upset stomach
• Constipation
• Abdominal pain
• Loss of appetite
• Itching
• Hypocalcemia

Inform your healthcare provider about your complete medical history, allergies, and ongoing medications or supplements to ensure safe usage. Regular monitoring of blood phosphate levels is important to assess the effectiveness of the Phostat 667mg tablet in managing hyperphosphatemia. Stick to dietary recommendations your healthcare provider provides to complement the medication's effects. Be vigilant for symptoms of hypercalcemia, such as nausea, vomiting, and confusion, as well as symptoms of hypocalcemia. If you experience any adverse effects, consult your healthcare provider, who may adjust the dosage or recommend alternative treatments. Pregnant and breastfeeding individuals should seek guidance from a healthcare provider before using this medication. Discuss your allergies, history of hypersensitivity reactions, or underlying conditions like liver or lung issues with your healthcare provider before starting them. Always consult your healthcare provider for personalized advice and guidance on the safe and effective use of this medication in your specific circumstances.

1. RenaCare NephroMed GmbH, Electronic Medicines Compendium (EMC), [Revised on Feb 2012] [Accessed on 22 August 2023], https://www.medicines.org.uk/emc/files/pil.4646.pdf
2. Genzyme Ireland Ltd, US Food and Drug Administration, [Revised on: 04/2020 ] [Accessed on 23rd August 2023] ,https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022127s019,022318s021lbl.pdf
3. J. Goddard, A.N. Turner, Kidney and Urinary Tract Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 461-523.