Why Freezing Eggs Is A Smart Option For Preserving Fertility In The Future?
2 May 2025
8 mins
Why Freezing Eggs Is A Smart Option For Preserving Fertility In The Future?More and more women today are postponing motherhood, not because they don’t want kids, but because they want the right time, the right partner, or simply the space to build their lives first. But biology? It doesn’t always wait. That’s where egg freezing steps in, not as a last resort, but as a smart, proactive choice.   In India, conversations around fertility preservation are finally picking up. What was once whispered about in fertility clinics is now openly discussed among friends, doctors, and even in boardrooms. From rising interest in metro cities to celebrities sharing their stories, egg freezing is no longer a hush-hush topic; it’s a tool many women are exploring to take control of their future.   In this blog, we’ll break down what egg freezing really means and if you’ve ever wondered whether it could be the right choice for you (or someone you know), keep reading. You might be surprised at just how empowering it can be.   WHAT DOES FREEZING EGGS MEAN?   Let’s simplify. Freezing eggs, also known as oocyte cryopreservation, is a method where a woman’s eggs are harvested, frozen, and stored for future use. When she’s ready to get pregnant (maybe years later), those eggs can be thawed, fertilised with sperm, and implanted into the uterus.   It’s like hitting the pause button on your fertility, but in a totally safe, medically-backed way.   WHY ARE SO MANY WOMEN OPTING FOR THIS?   A woman’s fertility declines with age, especially after 35. Yet, the average age of motherhood is rising. Careers, education, finances, and not finding the right partner (ugh, dating apps) are all valid reasons women choose to wait.   And the numbers are speaking loud and clear. A study [https://pubmed.ncbi.nlm.nih.gov/38164426/] analysing data from the National Family Health Survey-5 (2019–21) found that the prevalence of infertility in India among women married for at least five years is approximately 18.7 per 1,000 women.   HOW DOES EGG FREEZING WORK?   You’re not alone if you’re wondering how egg freezing works. It's a pretty common question. Here's a simple breakdown of the egg freezing process:   1. Hormonal stimulation: You’ll take hormone injections for 10–14 days to stimulate your ovaries to produce multiple eggs.   2. Egg retrieval: Once your eggs are mature, a doctor collects them using a minor procedure under sedation.   3. Freezing: The eggs are frozen using a method called vitrification and stored safely in a lab.   That’s it! Think of it as your fertility insurance policy.     IS THERE A BEST AGE TO FREEZE EGGS?   Absolutely. The egg freezing age limit varies, but fertility experts agree that the best age to freeze eggs is between 27 and 35 years. Why? Because younger eggs = better quality = higher chances of success later on.   You can freeze your eggs up to age 40 (some clinics accept older), but the chances of a successful pregnancy decrease as you age. Quality matters more than quantity here.   Dr. Prachi Benara [https://birlafertility.com/blogs/best-age-to-freeze-your-eggs], a seasoned fertility expert, emphasises, "The best age for freezing your eggs is generally before 35, as egg quality and quantity decline significantly after this age."   Supporting this, a study [https://link.springer.com/epdf/10.1007/s10815-020-01791-w?sharing_token=5aJMPlNNTd2Lpy55EKMYUfe4RwlQNchNByi7wbcMAY52MkJi-03fy3R8QlAUPDUXI7F-oi_YXVldV0sf3AKhF6vLMpipo1fUorXJhOToCt5qlLs07g20-OrtikK0T3uGl7gWuuwJnFR_oK_wErpuO9oyTnBD-c-caiJgQ7uj3YE=] published in the Journal of Assisted Reproduction and Genetics indicates that a woman under 35 will need approximately nine eggs to achieve a 70% chance of having at least one live birth. However, if you're trying to conceive in your mid to late 30s, you may need twice as many eggs to achieve that same 70% success rate.  [https://www.cofertility.com/freeze-learn/a-breakdown-of-egg-freezing-success-rates-by-age?utm_source=chatgpt.com]   Moreover, data from FertilityIQ [https://www.fertilityiq.com/fertilityiq/articles/how-many-frozen-eggs-guarantees-success] reveals that women who stored 10 eggs after the age of 35 had a 30% success rate, whereas women under 35 with the same number of eggs had twice that success rate.   In summary, while egg freezing is possible up to age 40, the optimal window is between 27 and 35 years, where the balance between egg quality and quantity offers the highest chances of future pregnancy success.   IS EGG FREEZING PAINFUL?   We won’t sugarcoat it. The idea of injecting hormones into your belly and undergoing a procedure can feel intimidating. But according to most women, it’s uncomfortable, not painful.   You might experience bloating, mild cramping, or mood swings, think PMS on steroids (literally). But it's temporary and manageable.   Dr. Rajendra Shitole [https://timesofindia.indiatimes.com/life-style/parenting/getting-pregnant/as-interest-in-egg-freezing-increases-busting-a-few-myths-about-this-assisted-reproduction-method/photostory/101784359.cms], IVF Consultant and Endoscopic Surgeon at DPU Private Super Speciality Hospital, Pimpri, Pune, says, “Egg freezing is generally considered safe and has become a routine procedure.”   HOW MUCH DOES IT COST TO FREEZE EGGS IN INDIA?   Let’s talk about the cost because egg freezing is an empowering choice, but it doesn’t come cheap.   The cost of egg freezing in India typically ranges between ₹1,00,000 to ₹1,50,000 for the initial cycle. This includes ovarian stimulation drugs, hormone injections, ultrasound monitoring, and the egg retrieval procedure. The medications alone can account for about ₹50,000 to ₹80,000, depending on your hormonal response and the clinic’s protocol.   According to a study published in the Journal of Human Reproductive Sciences (JHRS), the average cost for elective egg freezing in India is around ₹1.2 lakh per cycle, though this can vary widely between metros and tier-2 cities.   After retrieval, the eggs are frozen and stored in liquid nitrogen tanks at -196°C. Storage fees generally range from ₹10,000 to ₹25,000 per year, depending on the clinic.   So if you freeze your eggs at age 30 and choose to store them for 5 years, you’re looking at a total of approximately ₹2 to ₹3.5 lakhs over that period.     WHERE CAN YOU FREEZE EGGS IN INDIA?   Many top-tier hospitals and fertility centres across India offer this service, including:   * Apollo Fertility (multiple cities) * Cloudnine Fertility (Pan India) * Nova IVF Fertility (30+ locations) * Fortis La Femme (Delhi, Bengaluru) * Morpheus IVF & Medicover Fertility   These clinics follow international cryopreservation protocols and are staffed by reproductive endocrinologists, embryologists, and counsellors to support your fertility journey.     ARE THERE ANY SUBSIDIES OR SCHEMES?   While egg freezing is not yet covered by insurance in most cases, some clinics offer EMIs or financial plans to make it more accessible. A few corporates (like Google, Meta, and Apple globally) also offer egg freezing benefits to employees, and this trend is slowly catching on in India, especially in the tech and finance sectors.   As of now, no government subsidy or Ayushman Bharat scheme directly covers elective egg freezing, though fertility preservation for cancer patients [https://www.mrmed.in/health-library/cancer-care/fertility-and-pregnancy-during-breast-cancer] may be partially covered in certain public healthcare programs or NGOs.     DOES FREEZING EGGS AFFECT FUTURE FERTILITY?   On the contrary, it preserves it. Freezing your eggs doesn’t reduce your chances of conceiving naturally in the future. In fact, it can improve your odds by giving you access to younger, healthier eggs later on.   Dr. Mallika Solanki [https://timesofindia.indiatimes.com/life-style/parenting/pregnancy/is-freezing-eggs-the-right-move-for-future-moms/articleshow/114422010.cms], Obstetrician & Gynaecologist, explains, “Freezing eggs does not harm the remaining ovarian reserve or reproductive function, and many women successfully conceive using frozen eggs without long-term complications.”     WHAT IS THE BIGGEST RISK OF EGG FREEZING?   Egg freezing is considered a safe and effective fertility preservation method, but it’s not without potential risks. The most serious, though rare, complication is ovarian hyperstimulation syndrome (OHSS). This occurs when the ovaries over-respond to fertility medications, causing them to swell and leak fluid. While mild OHSS (abdominal bloating, nausea) affects up to 33% of women, severe cases marked by rapid weight gain, shortness of breath, or blood clots occur in less than 1%.   Other possible side effects include:   * Abdominal bloating * Breast tenderness * Temporary weight gain * Mood swings * Constipation [https://www.mrmed.in/health-library/gastroenterology/types-of-constipation] * Mild pelvic discomfort   Women with polycystic ovary syndrome (PCOS) [https://www.mrmed.in/health-library/womens-health/pcos-symptoms-treatment] may be more prone to complications. Fortunately, most symptoms are short-lived, and advancements in hormone protocols have significantly reduced severe outcomes. Doctors now tailor medication doses, monitor patients closely, and may use a “freeze-only” strategy to minimise OHSS risk.   Staying hydrated and following your doctor’s guidance during stimulation is essential for a safe and smooth recovery.   SO… IS IT ACTUALLY SUCCESSFUL?   Good question! The success of egg freezing depends on several factors, such as age at freezing, number of eggs retrieved, and overall health. But here are some optimistic stats:   * Women under 35 who freeze 10–15 eggs have a 60–70% chance of live birth later. * Success rates are improving thanks to advanced vitrification techniques.   In 2022 [https://www.sciencedaily.com/releases/2022/05/220526181147.htm], a study published in Fertility and Sterility reported that women who froze eggs before 35 and used them later had similar success rates to IVF using fresh eggs [https://www.mrmed.in/health-library/health-care/complete-guide-ivf-treatment-medicines]. That's huge!     WHAT ARE THE ADVANTAGES AND DISADVANTAGES OF EGG FREEZING?   Egg freezing, or oocyte cryopreservation, offers women the opportunity to preserve their fertility for future family planning. While it provides several advantages, it's essential to consider the associated risks and limitations.   Advantages:   * Preservation of Fertility: Freezing eggs at a younger age allows women to use healthier eggs later, potentially reducing the risk of age-related infertility. * Reproductive Autonomy: Provides flexibility for women to delay childbearing due to personal, professional, or medical reasons. * Medical Necessity: Beneficial for women undergoing treatments like chemotherapy [https://www.mrmed.in/health-library/cancer-care/chemotherapy-breast-cancer] that may affect fertility.   Disadvantages:   * Cost: The procedure can be expensive, and insurance coverage varies. * Medical Risks: Involves hormone injections and egg retrieval, which carry risks such as ovarian hyperstimulation syndrome (OHSS). * No Guarantee: While success rates have improved, there's no certainty of achieving pregnancy from frozen eggs.   It's crucial to consult with a fertility specialist to understand the potential outcomes and make an informed decision.   FREQUENTLY ASKED QUESTIONS (FAQS)   Q. 1) Should you freeze your eggs?   Egg freezing can be a good option for women who want to delay childbearing for personal, professional, or medical reasons. It allows you to preserve your fertility at a younger age, ensuring healthier eggs for future use. However, it’s important to consider the costs, medical risks, and the fact that it doesn’t guarantee a successful pregnancy.     Q. 2) What is the best age to freeze eggs?   The best age to freeze eggs is between 27 and 35 years, as this is when egg quality and quantity are optimal. Freezing eggs earlier increases the chances of success, as eggs are healthier and more viable for future use.     Q. 3) How successful is egg freezing?   Women under 35 who freeze their eggs have up to a 70% success rate if enough eggs are retrieved and stored. Success rates decline as women age, particularly after 38, as egg quality diminishes over time.     Q. 4) Why Did Priyanka Chopra Freeze Her Eggs?   Priyanka Chopra froze her eggs in her early 30s on the advice of her mother, a physician, so she could focus on her career without the pressure of fertility concerns. This is a growing trend among women, especially in India, who are planning their futures and choosing to delay motherhood.     Q. 5) What Are the Benefits of Freezing Your Eggs?   Egg freezing allows women to preserve fertility for future family planning, reducing age-related infertility concerns. It provides reproductive flexibility, especially for those facing medical treatments or those who aren’t ready for children but want to ensure options in the future.     Q. 6) Does freezing eggs stop periods?   No, freezing eggs does not stop your periods. Your menstrual cycle and ovulation will continue as usual during the egg retrieval process. Only the eggs that would naturally be released that month are harvested, and it does not impact your overall egg count or cause early menopause [https://www.mrmed.in/health-library/womens-health/manage-menopause-symptoms].   IT’S YOUR TIMELINE, YOUR RULES.   Egg freezing offers women the opportunity to take control of their reproductive future, providing flexibility to delay motherhood without sacrificing fertility. While it can be an empowering option for those focusing on their careers, personal goals, or medical treatments, it’s important to weigh the costs, risks, and success rates. Consulting with a fertility specialist is essential to make an informed decision tailored to your unique needs. Take charge of your timeline and ensure you have the options available when you’re ready.   READ ALSO   * MrMed Women's Health Library [https://www.mrmed.in/health-library/womens-health] * Can Diabetes Cause Infertility in Women? [https://www.mrmed.in/health-library/womens-health/can-diabetes-cause-infertility-in-females]   REFERENCES   1. https://www.rcog.org.uk/for-the-public/browse-our-patient-information/ovarian-hyperstimulation-syndrome/ [https://www.rcog.org.uk/for-the-public/browse-our-patient-information/ovarian-hyperstimulation-syndrome/] 2. https://www.nhlbi.nih.gov/news/2019/egg-consumption-linked-higher-risk-heart-disease-and-death [https://www.nhlbi.nih.gov/news/2019/egg-consumption-linked-higher-risk-heart-disease-and-death] 3. https://newsinhealth.nih.gov/2022/07/having-kids-later-life [https://newsinhealth.nih.gov/2022/07/having-kids-later-life] 4. https://pubmed.ncbi.nlm.nih.gov/25881876/ [https://pubmed.ncbi.nlm.nih.gov/25881876/]
Dr. Tejashwin Adiga
Understanding Liver Health: Preventive Measures and Treatment Options
30 Apr 2025
8 min
Understanding Liver Health: Preventive Measures and Treatment OptionsThe liver plays a key role in maintaining your health. It filters toxins, supports digestion, and stores energy. However, liver problems often go unnoticed until symptoms appear, which is why it's important to understand the early signs and take steps to protect the liver.   Whether you're worried about liver disease [https://www.mrmed.in/health-library/liver-care/liver-disease-awareness], have a family history of liver disease, or just want to feel your best, this guide will walk you through everything you need to know, without the medical Knowledge.   WHY YOUR LIVER DESERVES MORE ATTENTION? Your liver does over 500 vital tasks like detoxifying your blood, breaking down fats, supporting metabolism, and storing important nutrients like iron and vitamins. But it's also surprisingly quiet when things go wrong. You may not notice any symptoms of liver problems until damage is already done.     WHAT ARE THE SYMPTOMS OF LIVER PROBLEMS? Here are a few symptoms that show you might have liver problems:   * Persistent fatigue or weakness * Swelling in the legs or abdomen * Dark-colored urine or pale stool * Itchy skin * Nausea * Mild pain in the upper right abdomen.     WHAT ARE THE CAUSES OF LIVER PROBLEMS?   1. Liver cirrhosis   Liver cirrhosis [https://my.clevelandclinic.org/health/diseases/15572-cirrhosis-of-the-liver] is a condition where healthy liver tissue is gradually replaced by scar tissue, leading to permanent liver damage. It develops over time, often due to continuous injury or inflammation in the liver.   Common causes of cirrhosis include:   * Long-standing hepatitis B or C infection * Excessive alcohol use over several years * Untreated non-alcoholic fatty liver disease (NAFLD), often linked to obesity or diabetes.   2. Fatty liver disease   Fatty liver disease occurs when too much fat builds up in the liver cells. It’s often silent in the early stages, meaning many people don’t know they have it until it’s found on a test or scan.   Common risk factors include:   * Being overweight or obese * Type 2 diabetes or insulin resistance * High triglyceride or cholesterol levels * Poor diet and lack of physical activity   Dr. Sachin Palnitkar, a renowned hepatologist [https://www.drpalnitkarsclinic.com/2020/12/23/india-diet-plan-non-alcoholic-fatty-liver-disease/], emphasises that maintaining liver health is crucial. He highlights that just as an unhealthy and imbalanced diet can lead to the development of a fatty liver, giving up on unhealthy dietary habits can help reverse the condition.   CAN FATTY LIVER DISEASE BE PREVENTED?   Yes, most cases of fatty liver disease can be prevented with simple lifestyle changes. Here’s how:   * Eat a balanced diet: Focus on vegetables, fruits, whole grains, and lean proteins.   * Exercise regularly: Walking for 30 minutes a day can help reduce liver fat.   * Manage chronic conditions: Control diabetes, high blood pressure, [https://www.mrmed.in/health-library/hypertension/high-blood-pressure-symptoms] and cholesterol.   Dr. Ashish Kumar, Senior Consultant at Sir Ganga Ram Hospital, [https://timesofindia.indiatimes.com/city/mangaluru/regular-exercise-balanced-diet-key-to-prevent-liver-ailments-experts/articleshow/81109393.cms?utm_source=chatgpt.com] emphasises the importance of maintaining a healthy weight and exercising regularly, as both are crucial in preventing and suppressing symptoms of non-alcoholic fatty liver disease.     HOW TO PREVENT HEPATITIS INFECTION?   Hepatitis [https://www.mrmed.in/health-library/viral-infections/hepatitis-types] is inflammation of the liver, which is caused by viruses like Hepatitis A, B, or C. Here’s how to lower your risk:   * Get vaccinated against Hepatitis A and B * Avoid sharing personal items like toothbrushes * Practice safe sex * Make sure sterile equipment is always used for any medical or tattoo procedures.     WHY IS LIMITING ALCOHOL ESSENTIAL FOR A FATTY LIVER?   Alcohol can be especially harmful if you already have fatty liver disease. Even small amounts may speed up liver damage and lead to serious complications. It's best to avoid alcohol altogether or keep your consumption minimal, as recommended by healthcare professionals.   LIVER SUPPLEMENTS: DO THEY WORK?   Some liver supplements claim to "detox" or "cleanse" the liver. While ingredients like milk thistle and turmeric may offer mild benefits, they aren’t miracle cures. Always talk to your doctor before starting any supplement, if you already have a liver condition or are on medication.     WHAT ARE THE TREATMENT OPTIONS FOR LIVER CIRRHOSIS?   While cirrhosis can’t be cured, it can be managed. Treatment may include:   1. Treating the underlying cause 1. Antiviral medicines for hepatitis B or C 2. Abstinence and counselling for alcohol-related liver disease 3. Lifestyle changes (like weight loss and diabetes control) for fatty liver disease   2. Medications to manage complications 1. Diuretics to reduce fluid buildup (ascites) 2. Beta-blockers or nitrates to lower portal hypertension 3. Lactulose for confusion caused by liver-related toxin buildup (hepatic encephalopathy)   3. Nutritional support 1. High-protein, low-sodium diet with vitamin supplementation 2. Avoiding raw seafood and alcohol completely.   DID YOU KNOW? YOUR LIVER DOESN’T FEEL PAIN UNTIL IT’S TOO LATE   Strange but true, your liver has no pain receptors like your skin or muscles. That means liver damage can silently progress for months or even years without obvious symptoms. Most people only discover a problem when the condition has advanced to fatty liver, hepatitis, or even cirrhosis.   That’s why regular health checkups, liver function tests, and being mindful of fatigue, digestive issues, or abdominal swelling are so important. Your liver might be quiet, but it’s constantly working and it deserves your attention.   FREQUENTLY ASKED QUESTIONS (FAQS)   1. What is fatty liver disease?   Fatty liver disease happens when too much fat builds up in your liver. It can cause damage over time, even if you don’t feel symptoms right away.   2. What causes fatty liver disease?   Poor diet, lack of exercise, obesity, and heavy alcohol use are common triggers. Other causes include diabetes, high cholesterol, and certain medications.   3. What does the liver do?   Your liver filters toxins, helps with digestion, and stores energy for your body. It also makes proteins and supports your immune system every single day.   4. What are the reasons for hepatitis A?   Hepatitis A spreads through contaminated food, water, or close contact with an infected person. Poor hand hygiene and lack of clean sanitation are the main causes.   5. What heals the liver faster?   The fastest way to heal the liver is to stop alcohol, eat a balanced diet, exercise regularly, and treat any underlying conditions.     FINAL THOUGHTS: TAKE CHARGE OF YOUR LIVER HEALTH   Your liver is one of the most vital organs in your body. It filters toxins, aids digestion, and keeps your system in balance. But it needs your support to stay strong. Simple habits like eating fresh foods, staying active, limiting alcohol, and avoiding unnecessary medications can go a long way in protecting it.   If you ever notice signs like fatigue, yellowing of the skin, or digestive problems, don’t ignore them. These could be early signs of liver trouble, and early action can make all the difference.   Remember, you don’t need fancy detoxes or extreme diets. A balanced lifestyle, regular check-ups, and informed choices are your best tools for long-term liver health. Treat your liver with care, Your liver quietly protects your health every day—take small steps today to return the favour for life. Start today with small steps, and your liver will thank you for a lifetime.   READ ALSO   1. What foods should I eat to support my liver health? [https://www.mrmed.in/health-library/liver-care/foods-to-support-liver-health] 2. Is your medication hurting your liver? 12 drugs to be aware of [https://www.mrmed.in/health-library/liver-care/liver-damage-from-medications] 3. Suffering from liver disease? 6 fruits & veggies to get rid of it [https://www.mrmed.in/health-library/liver-care/liver-disease] 4. How to recognise liver problems in 3 simple steps [https://www.mrmed.in/health-library/liver-care/recognize-liver-problems] 5. What are the symptoms of liver damage? [https://www.mrmed.in/health-library/liver-care/liver-damage-symptoms]     REFERENCES 1. https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-patients-liver-scarring-due-fatty-liver-disease [https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-patients-liver-scarring-due-fatty-liver-disease] 2. https://pmc.ncbi.nlm.nih.gov/articles/PMC10890057/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC10890057/] 3. https://globalliver.org/wp-content/uploads/2022/08/Liver-Health-Basics-Booklet.pdf [https://globalliver.org/wp-content/uploads/2022/08/Liver-Health-Basics-Booklet.pdf] 4. https://www.sciencedirect.com/science/article/pii/S0168827812009245 [https://www.sciencedirect.com/science/article/pii/S0168827812009245]
Dr. Vijayalakshmi
Easy Ways to Stay Healthy This Summer
16 Apr 2025
8 mins
Easy Ways to Stay Healthy This SummerSummer has its perks, long days, beach vibes, mangoes on repeat, but it can also leave you feeling totally wiped out if you’re not careful. Remember that old Glucon-D ad where the sun is shown drinking your energy through a straw? Yeah, it’s kinda like that.   The heat can sneak up on you, causing dehydration, fatigue, and that sluggish, can’t-move-from-the-sofa feeling. But here’s the good part: staying healthy in summer doesn’t need to be complicated. With a few smart, doable summer health tips, from simple diet tweaks to sun safety musts, you can beat the heat like a pro.   Consider this your go-to summer season health tips guide. Save it, share it, and thank us when the sun starts turning up the heat!   WHAT ARE THE BEST WAYS TO STAY HEALTHY IN THE SUMMER?   Think of summer as a wellness boot camp, minus the boot camp. It’s the perfect time to eat better, move more, and hydrate like your life depends on it (because, sometimes, it does).   Here are the basics:   * Drink water like it’s your job * Load up on cooling foods * Protect your skin from UV damage * Avoid peak sun hours * Keep your body moving, but wisely * Listen to your body signals   And if you’re still winging it without sunscreen [https://www.mrmed.in/molecule/sunscreen] or skipping meals because “it’s too hot to eat,” we need to talk.   HOW TO MAINTAIN HYDRATION DURING HOT WEATHER?   First rule of summer season health tips? Hydration. According to the CDC [https://www.cdc.gov/nchs/products/databriefs/db242.htm], adults should aim for at least 2.7 to 3.7 litres of fluids per day, and this need increases significantly in summer due to sweating. Yet, surveys show that nearly 75% of adults in India are chronically dehydrated.   Hydration tips to live by:   * Don’t wait to feel thirsty. Sip water throughout the day. If your mom’s anti-fridge (like mine), go old-school. Matka (earthen pot) water is naturally cool [https://timesofindia.indiatimes.com/life-style/food-news/benefits-of-drinking-earthen-pot-water-in-summer/articleshow/109248841.cms]and even studies say it’s good for digestion and sunstroke prevention. * Add natural electrolytes. Instead of falling for flashy powder drink ads (you know the ones), stick to healthy tips for summer drinks [https://www.mrmed.in/health-library/health-care/top10-summer-drinks] like lemon water, coconut water, or homemade nimbu pani with a pinch of salt and sugar. * Eat water-rich foods like watermelon, cucumbers, oranges, and strawberries. You can also freeze fruit chunks in water or make popsicles for the kids (or yourself, no shame) and make this summer fun. * Carry a reusable bottle, seriously, make it your summer accessory.   WHAT SHOULD I EAT TO STAY COOL AND HEALTHY IN SUMMER?   When it’s blazing outside, your body naturally craves light, refreshing food—and honestly, it’s smart like that. Studies say that eating more fruits and veggies in the heat can actually help lower your core body temperature by up to 2°C. That’s a game-changer when you’re melting under the sun. Knowing how to stay healthy in summer starts with knowing what to eat.   Nutritionist Nmami Agarwal [https://www.ndtv.com/health/what-should-your-summer-plate-look-like-nutritionist-nmami-agarwal-reveals-2411587] recommends loading up on seasonal produce and light meals to keep your energy up and digestion happy during summer. Think easy-to-digest, hydrating foods that won’t weigh you down.   Here’s your go-to summer food [https://www.mrmed.in/health-library/health-care/top10-summer-foods] list:   * Fruits: Watermelon, mangoes, lychees, berries, papayas * Veggies: Cucumber, tomato, zucchini, leafy greens * Dairy: Buttermilk, curd, chilled smoothies * Extras: Coconut water, mint, fennel seeds, chia seeds   What to skip? Heavy fried stuff and red meat. They build up heat in the body and can make you feel sluggish. Try wrapping up dinner before 8 PM and keep it light. Your gut will sleep better, and so will you.   HOW CAN I PREVENT DEHYDRATION IN HOT WEATHER?   Dehydration doesn’t always feel dramatic. Sometimes, it's just fatigue, dry mouth, or dizziness.    SIGNS TO WATCH FOR:   * Dry lips and skin * Reduced urination or dark-colored pee * Muscle cramps * Irritability or lack of focus   Stay ahead of it:   * Keep ORS or electrolyte drinks handy. * Add fruits like musk melon and pomegranate to meals. * Avoid carbonated drinks and alcohol—they dehydrate faster than you think.   TIPS FOR EXERCISING SAFELY IN THE SUMMER HEAT   Yes, you can still work out. No, it shouldn’t be under the 2 PM sun.   Tips that keep you safe:   * Stick to shaded or indoor areas. * Choose breathable fabrics. Do not wear dark coloured clothes. * Listen to your body, pause if you feel dizzy or too hot. * Try swimming or yoga as low-impact, summer-friendly options.   Bonus tip: Post-workout? Coconut water > energy drinks. Always.   WHAT’S THE IMPORTANCE OF SUNSCREEN IN SUMMER?   Let’s keep it simple - sunscreen is not optional.   Even on cloudy days, UV rays do their sneaky damage. Over time, unprotected exposure can lead to skin ageing, sunburns, or worse - skin cancer.   Dr. Mona Gohara, a board-certified dermatologist, [https://www.glamour.com/story/does-sunscreen-prevent-tanning] recommends using SPF 50+ broad-spectrum sunscreen, reapplying every two hours, and incorporating other sun protection measures like wearing protective clothing and seeking shade during peak UV hours.   Remember these sunscreen rules:   * Apply 15 minutes before stepping out * Don’t skip ears, neck, and feet * Use a gel-based formula if you have oily skin * Reapply, no matter how waterproof it claims to be   WHAT’S AN IDEAL SUMMER SKINCARE ROUTINE FOR OILY SKIN?   Oily skin in summer = breakouts, grease, and shine. But don’t worry, it’s manageable with a simple summer skincare [https://www.mrmed.in/health-library/skin-care/skincare-tips-summer] routine.   Your no-fuss routine:   1. Cleanse: Twice a day with a gel-based face wash. Products like CeraVe Foaming Facial Cleanser and Neutrogena's Ultra Gentle Daily Cleanser are known for effective oil removal without over-drying.   2. Tone: Use rose water or an alcohol-free toner.   3. Moisturise: Yes, even oily skin needs moisture. Go for non-comedogenic gel moisturisers.   4. Sunscreen: Lightweight, matte finish SPF 50.   5. Weekly Detox: Try a clay mask or charcoal pack. Don’t overwash your face. It’ll trigger more oil production.   HOW TO PREVENT HEATSTROKE AND STAY COOL NATURALLY?   Heatstroke can be dangerous, and it creeps up fast. India experienced nearly 25,000 suspected heatstroke cases [https://www.reuters.com/world/india/heat-wave-kills-least-56-india-nearly-25000-heat-stroke-cases-march-may-2024-06-03/] and at least 56 deaths between March and May 2024 due to severe heat waves.   Stay ahead of it by watching your exposure and energy levels.   Top prevention tips:   * Stay indoors from 11 AM to 4 PM. * Use cooling herbs like mint or coriander in food and drinks. * Wear loose, cotton clothes in light shades. * Drink herbal teas like hibiscus or chamomile iced.   Quick fix: Soak your feet in cold water after being out—instant body temp relief.   WHAT ARE SOME EASY WAYS TO STAY HEALTHY DURING THE SUMMER AT HOME?   Summer wellness doesn’t always need big changes—just smart tweaks.   * Keep curtains closed to block heat * Switch to cotton bedsheets * Drink herbal teas before bed * Wake up early for morning walks * Add lemon and cucumber slices to your water pitcher   FREQUENTLY ASKED QUESTIONS (FAQS)   1. How much water is enough during summer?   In hot weather, adult men should aim for 3.7–4 litres and women for 2.7–3 litres of fluids daily, including water, beverages, and moisture from foods. If you're sweating heavily or exercising, increase your intake by 0.5–1 litre per hour of activity. Monitoring urine colour, pale yellow, indicates good hydration, which is a practical way to assess your fluid needs.  [https://timesofindia.indiatimes.com/life-style/health-fitness/diet/how-much-water-should-you-drink-in-summer-to-feel-hydrated-in-summer/articleshow/110704251.cms?utm_source=chatgpt.com]   2. Can I skip sunscreen on indoor days?   No, it's advisable to wear sunscreen indoors. UVA rays can penetrate glass windows, potentially leading to skin ageing and damage over time. Additionally, blue light from screens may contribute to skin issues. Applying a broad-spectrum SPF daily helps protect your skin, even when you're inside.   3. Are smoothies okay in summer diets?   Absolutely! Smoothies made with fresh fruits, vegetables, and yoghurt or plant-based milk are hydrating and nutrient-rich. They provide essential vitamins, minerals, and fibre, supporting overall health. Just be cautious with added sugars; opt for natural sweetness from fruits.   4. What’s a quick summer snack that’s also healthy?   Frozen grapes are a refreshing and hydrating treat. Fruit chaat, combining various fruits with a dash of chaat masala, offers a flavorful and nutritious option. Cucumber sticks paired with hummus provide a crunchy, fibre-rich snack that's both satisfying and cooling.   5. How often should I shower in summer?   Showering once daily is generally sufficient for most people. If you're sweating heavily or exposed to pollutants, a second shower may be beneficial. Use lukewarm water to prevent skin dryness, and avoid harsh soaps to maintain the skin's natural barrier.   LET’S WRAP THIS UP    Summer doesn't have to drain you. In fact, it can be your healthiest season yet—with the right habits. Prioritise hydration, eat smart, take sun protection seriously, and move your body when it feels right.   You don’t need perfection, you need consistency.   So go ahead, chill your watermelon, grab that SPF, and soak up the sunshine (safely). Your summer glow-up starts now!   READ ALSO   * Home Remedies For Glowing Skin [https://www.mrmed.in/health-library/skin-care/home-remedies-for-glowing-skin]   REFERENCES   1. https://timesofindia.indiatimes.com/life-style/health-fitness/diet/how-much-water-should-you-drink-in-summer-to-feel-hydrated-in-summer/articleshow/11070425 [https://timesofindia.indiatimes.com/life-style/health-fitness/diet/how-much-water-should-you-drink-in-summer-to-feel-hydrated-in-summer/articleshow/110704251.cms] 2. https://www.nhs.uk/live-well/eat-well/how-to-eat-a-balanced-diet/eight-tips-for-healthy-eating/ [https://www.nhs.uk/live-well/eat-well/how-to-eat-a-balanced-diet/eight-tips-for-healthy-eating/] 3. https://www.cdc.gov/nutrition/features/healthy-eating-tips.html [https://www.cdc.gov/nutrition/features/healthy-eating-tips.html] 4. https://www.cdc.gov/ncird/whats-new/stay-healthy-during-holidays.html [https://www.cdc.gov/ncird/whats-new/stay-healthy-during-holidays.html]
Dr. Tejashwin Adiga
India’s Risdiplam Launch Cuts SMA Drug Cost to ₹15K
14 Apr 2025
8 mins
India’s Risdiplam Launch Cuts SMA Drug Cost to ₹15KA major breakthrough has just made waves in India’s healthcare scene — a new treatment for spinal muscular atrophy (SMA) is finally here. This isn’t just medical news; it’s life-changing for hundreds of families across the country who’ve been waiting for hope, access, and affordability.   For years, SMA patients in India have faced two tough choices: either import an expensive treatment or go without. Now, with the launch of a cost-effective oral medication by Natco Pharma, things are finally looking up.   In this blog, we’ll walk you through everything you need to know — what SMA is, why this launch matters, how it’s stirring legal debates between Natco and Roche, and most importantly, what this means for Indian families. We've also included expert opinions, current pricing updates, and answers to common questions. Let’s break it all down.   WHAT’S ALL THE BUZZ ABOUT THIS NEW DRUG LAUNCH IN INDIA?   Known globally for its effectiveness, the drug has now entered the Indian market in a more accessible form. The credit goes to Natco Pharma, which introduced a generic version of the original molecule developed by Swiss giant Roche.   Until now, Indian patients were largely cut off from this life-saving medication [https://www.mrmed.in/] because of high costs and limited availability. Natco’s move is being called a “ray of hope” by several health experts. In fact, Dr. Sheffali Gulati [https://health.economictimes.indiatimes.com/news/industry/the-recent-launch-of-the-oral-drug-evrysdi-risdiplam-in-india-is-a-ray-of-hope-for-sma-patients-dr-sheffali-gulati-child-neurology-division-aiims/86054972], Head of Child Neurology at AIIMS, New Delhi, told ET Healthworld, “This launch is a significant step forward for SMA patients in India, especially for early-stage cases where timely treatment can transform outcomes”   HOW SERIOUS IS SPINAL MUSCULAR ATROPHY, AND WHY IS THIS DRUG A BIG DEAL?   SMA is a progressive genetic disorder that affects nerve cells in the spinal cord, leading to muscle wasting and weakness. It’s among the top genetic causes of infant mortality worldwide.   In India, access to SMA therapies has been particularly grim. The injectable alternatives required hospitalisation and cost crores annually. This new oral solution brings a massive shift, not just in how it's administered but also in who can afford it. It can be taken at home, sparing families from endless hospital visits and medical procedures.   WHO’S BEHIND THE LAUNCH, AND WHY IS THERE LEGAL DRAMA?   The excitement comes with some courtroom tension. Natco Pharma launched its version of the drug amidst a high-profile patent dispute with Roche. Natco claims its move is protected under India’s compulsory licensing provisions, which allow the production of generics for public health needs.   The Natco Pharma vs Roche patent battle has been playing out in Indian courts and is now one of the most significant pharmaceutical IP cases in recent memory. On the other side, Roche is holding firm on its patent rights, arguing that the launch undermines years of research investment.   But, according to Dr. Melissa Barber [https://www.indiatoday.in/health/story/how-rare-genetic-disease-sma-drug-risdiplam-priced-at-rs-72-lakh-can-be-developed-in-rs-3000-2627702-2024-11-05] from Yale University, India has every reason to make this move. In a presentation cited by the Times of India, she noted, “If India chooses to manufacture locally, the same drug could cost as little as ₹3,000 per year”   HOW MUCH DOES THE TREATMENT COST IN INDIA NOW?   Let’s talk numbers. Before this launch, families paid an astronomical ₹6 - 8 lakh every month or over ₹70 lakh a year. That’s not something the average household could even dream of affording.   This significant price drop is a major relief for patients and advocacy groups who have long campaigned for more affordable rare disease [https://www.mrmed.in/health-library/health-care/rare-disease-day] treatments in India.   IS IT APPROVED AND SAFE TO USE?   Yes, this isn’t a grey-market drug. The Risdiplam approval in India followed a rigorous evaluation by national regulatory bodies. Authorities reviewed international clinical trial data along with Indian studies to ensure the generic was up to the mark.   The drug is already approved in over 80 countries and has shown strong safety and efficacy profiles, especially in early-stage SMA cases. Its oral form is particularly beneficial for children and patients with mobility issues.   WHAT’S NEXT FOR THE SMA COMMUNITY IN INDIA?   This isn’t just about one medicine. The ripple effects of this launch could be felt across the rare disease landscape in India. More pharmaceutical companies may now consider pursuing compulsory licenses for other high-cost treatments, especially for rare and orphan diseases [https://www.mrmed.in/health-library/health-care/orphan-drugs-rare-diseases].   It also puts pressure on the government to formalise frameworks for rare disease management and funding. Financial aid schemes have started rolling out, but families still report bureaucratic delays.   Still, hope is in the air—and it's not just because of a single drug. It's because of a shift in mindset. Accessibility is becoming a priority, and that could lead to real, long-term change.   FREQUENTLY ASKED QUESTIONS (FAQS)   Q.1) What is the name of the new SMA drug launched in India? The new SMA drug launched in India is a generic version of risdiplam, recently introduced by Natco Pharma. It offers a more affordable alternative to the brand-name drug Evrysdi. This launch marks a significant step toward making SMA treatment more accessible in India.     Q.2) How much is a bottle of risdiplam?   The price of a bottle of risdiplam in India varies significantly depending on the manufacturer. Roche's brand-name version, marketed as Evrysdi, is priced at approximately ₹6.2 lakh per bottle. In contrast, Natco Pharma has introduced a generic version of risdiplam at a much lower cost of ₹15,900 per bottle. This stark price difference highlights ongoing efforts to improve accessibility and affordability for patients who rely on this essential medication.     Q.3) Who can use Risdiplam? Risdiplam is prescribed for individuals diagnosed with Spinal Muscular Atrophy (SMA) Types 1, 2, and 3. A healthcare professional will determine eligibility based on the patient’s condition and medical history. It is important to undergo proper evaluation before starting the treatment.     Q.4) What about side effects? Common side effects of risdiplam may include diarrhea, rash, and fever. Some patients might experience other symptoms, which should be reported to a doctor immediately. Always consult a healthcare provider before starting the medication to assess potential risks and benefits.     Q.5) Can we get financial help for this treatment? Yes, financial assistance is available through various avenues in India. The National Policy for Rare Diseases (NPRD) [https://sansad.in/getFile/annex/258/AU1551.pdf] 2021 provides up to ₹50 lakh per patient for treatment at designated Centers of Excellence. Additionally, NGOs like the Care and Protection of Children Trust (CPCT) have partnered with pharmaceutical companies to offer lifelong free access to Risdiplam for eligible children. Some state governments, such as Karnataka, have also initiated programs to support SMA patients. It's advisable to consult with local SMA support groups and healthcare providers to explore these options.   PARTING WORDS   This launch represents more than just a new drug; it signifies a shift in India's approach to treating rare diseases. The introduction of an affordable, effective treatment for SMA sets a precedent for future developments in the healthcare sector.   The ongoing patent case between Natco Pharma and Roche underscores the importance of balancing intellectual property rights with public health needs. As the situation evolves, it may pave the way for increased accessibility to essential medications for rare diseases [https://www.mrmed.in/speciality] in India.   Stay informed as this story continues to develop, potentially reshaping the landscape of rare disease treatment in the country.   READ ALSO   * Rare Disease Day [https://www.mrmed.in/health-library/health-care/rare-disease-day] * Orphan Drug Treatments For Rare Diseases [https://www.mrmed.in/health-library/health-care/orphan-drugs-rare-diseases]     REFERENCES   1. https://health.economictimes.indiatimes.com/news/policy/sc-to-hear-pleas-over-rs-50-lakh-cap-on-centre-aid-for-rare-diseases/120115704 [https://health.economictimes.indiatimes.com/news/policy/sc-to-hear-pleas-over-rs-50-lakh-cap-on-centre-aid-for-rare-diseases/120115704] 2. https://timesofindia.indiatimes.com/india/rs-72-lakh/year-rare-disease-drug-can-be-made-for-rs-3000/year-hc-told/articleshow/114666406.cms [https://timesofindia.indiatimes.com/india/rs-72-lakh/year-rare-disease-drug-can-be-made-for-rs-3000/year-hc-told/articleshow/114666406.cms] 3. https://www.pharmabiz.com/NewsDetails.aspx?aid=177199&sid=2 [https://www.pharmabiz.com/NewsDetails.aspx?aid=177199&sid=2] 4. https://economictimes.indiatimes.com/industry/healthcare/biotech/healthcare/health-groups-raise-concerns-over-patents-for-rare-disease-drugs/articleshow/114991405.cms [https://economictimes.indiatimes.com/industry/healthcare/biotech/healthcare/health-groups-raise-concerns-over-patents-for-rare-disease-drugs/articleshow/114991405.cms] 5. https://pubmed.ncbi.nlm.nih.gov/35284988/ [https://pubmed.ncbi.nlm.nih.gov/35284988/] 6. https://pmc.ncbi.nlm.nih.gov/articles/PMC10977425/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC10977425/]
Dr. Vijayalakshmi
Turmeric & Curcumin: Can This Golden Spice Support Cancer Care?
11 Apr 2025
7 mins
Turmeric & Curcumin: Can This Golden Spice Support Cancer Care?Turmeric - the spice in your kitchen that turns curry bright yellow has been around for over 4,000 years. It’s not just there to stain your countertops. Turmeric contains curcumin, the superstar compound researchers are obsessing over.   To be clear, turmeric doesn't cure cancer. However, studies suggest [https://www.mdpi.com/2227-9059/9/9/1086] it might assist in the fight. Curcumin has demonstrated anti-inflammatory, antioxidant, and potential anticancer properties in laboratory settings. This is noteworthy because chronic inflammation can contribute to cancer development.   A 2020 review in Frontiers in Oncology [https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1438040/full] showed that curcumin might interfere with cancer cell signaling. In simple terms, it could slow down or even stop cancer cells from growing or spreading.   Turmeric is often part of natural cancer treatment [https://www.mrmed.in/health-library/cancer-care/herbal-remedies-lung-cancer-benefits] discussions, not because it's magic but because it's potentially supportive. Plus, it’s low-risk and easy to add to your diet. So yes, turmeric could be good for cancer patients, but only as part of a bigger plan your doctor approves. Dr. Sandeep Nayak, a renowned oncologist in Bangalore, emphasises [https://drsandeepnayak.com/blogs/turmeric-as-a-cure-for-cancer/]: “While turmeric shows promise in preliminary studies for its anti-inflammatory and antioxidant properties, it should not replace conventional treatments. Patients should rely on evidence-based medical care.”    Let's read further to understand how turmeric and curcumin might support cancer care [https://www.mrmed.in/health-library/cancer-care].   WHAT’S THE DEAL WITH CURCUMIN AND CANCER?   Let’s start with the golden question (literally). Curcumin [https://www.mrmed.in/molecule/curcumin] is turmeric’s most active compound. Think of it as the Beyoncé of the spice world - stealing the spotlight with its powerful moves.   Curcumin and cancer research has exploded in the last two decades. Over 3,000 studies, to be exact. Researchers are exploring its potential in nearly every cancer type - breast, prostate, lung, colorectal, and even brain tumours [https://www.mrmed.in/health-library/cancer-care/world-brain-tumor-day-2023].   Here’s what’s fascinating:   * Curcumin may inhibit tumor growth by cutting off the blood supply (anti-angiogenesis). * It might also boost the body’s natural defenses, like enhancing apoptosis (aka programmed cell death) in cancer cells. * Some studies [https://www.cancer.gov/about-cancer/treatment/cam/hp/curcumin-pdq] show that curcumin could make chemo or radiation work better by sensitising cancer cells to these treatments.   The catch? Curcumin has low bioavailability [https://pmc.ncbi.nlm.nih.gov/articles/PMC5630447/]; your body doesn’t absorb it well. That’s where supplements or nano curcumin (we’ll get to that) come in.   HOW DOES CURCUMIN ACTUALLY AFFECT CANCER CELLS?   The effect of curcumin on cancer cells boils down to how it interrupts their bad behavior. In lab settings, curcumin seems to:   * Stop cancer cells from multiplying by disrupting their cell cycle. * Encourage them to self-destruct (yes, like little cancer cell kamikazes). * Reduce inflammation that creates a cozy home for tumors.   In fact, researchers have seen positive effects in colorectal cancer, in particular. That’s because the digestive tract is where curcumin gets the most exposure. Colorectal cancer studies [https://pmc.ncbi.nlm.nih.gov/articles/PMC9072734/] have shown that curcumin might slow down tumour growth and reduce markers like COX-2 and NF-kB (both are linked to inflammation and cancer spread).   That’s one reason curcumin is being looked at seriously in cancer clinical trials, especially for digestive tract cancers.   NANO CURCUMIN VS. REGULAR CURCUMIN – WHICH IS BETTER?   Ah, the new kid on the block: nano curcumin [https://www.mrmed.in/molecule/nano-curcumin]. Remember how we said curcumin doesn’t absorb well? Nano curcumin solves that by making curcumin particles teeny-tiny—so your body actually soaks it up.   That means nano curcumin tablets could deliver more benefits with less quantity. People ask, “What’s the difference between curcumin and nano curcumin?” Here it is:   Feature Regular Curcumin Nano Curcumin Absorption Poor Enhanced (~20-40x better) Dosing Higher required Lower doses effective Bioavailability Low High Supplement options Powder, capsules Tablets, liquids, injectables   Nano curcumin tablet uses? They’re being studied for everything from inflammation reduction to support in cancer treatment.   CAN TURMERIC SLOW CANCER GROWTH?   Short answer? Maybe.   Long answer? It depends on the type of cancer, your body, and what else is going on.   Can curcumin slow cancer growth? In vitro (test tube) and animal studies say yes. It slows down certain proteins and genes that help tumors grow, kind of like putting the brakes on a runaway car.   For example:   * It blocks VEGF [https://www.sciencedirect.com/science/article/abs/pii/S1043661818315032] (vascular endothelial growth factor), which helps cancer cells grow new blood vessels. * It slows down mTOR [https://link.springer.com/article/10.1007/s10787-025-01643-y], a protein that tells cancer cells to keep multiplying.   Clinical trials are still catching up, but the early signs are hopeful. Just remember: turmeric alone isn't a treatment, but it might be a helpful sidekick.   HOW CAN YOU USE TURMERIC FOR CANCER TREATMENT NATURALLY?   Let’s make this practical. Here’s how to get turmeric’s benefits:   1. Golden Milk – Warm plant milk, turmeric, black pepper, and honey.   2. Curcumin Supplement – Choose ones with piperine or liposomal delivery for better absorption.   3. Nano Curcumin Tablets – Best absorption [https://journal.ppcr.org/index.php/ppcrjournal/article/view/296], but often more expensive.   4. Turmeric in Cooking – Curries, soups, smoothies.   Pro Tip: Always pair turmeric with black pepper; it boosts curcumin absorption by 2000% [https://pmc.ncbi.nlm.nih.gov/articles/PMC3535097/] (yep, really).   If you’re thinking about adding turmeric or curcumin supplements to your routine, chat with your healthcare provider first, especially if you're undergoing treatment.   WHAT HERBS HELP FIGHT CANCER BESIDES TURMERIC?   Turmeric might be the golden star, but it’s not working solo in the herb squad. “I think people can forget, or don’t realise, that herbs are plants and contain a wide variety of phytochemicals, vitamins, minerals and antioxidants,” says Candice Schreiber, RD, CSO, LD, a JamesCare for Life [https://cancer.osu.edu/for-patients-and-caregivers/support-for-patients-and-caregivers/support-programs/jamescare-for-life] outpatient clinical dietician.   Several other herbs and spices are being explored for their potential cancer-supporting benefits:   * Ginger – Known for its anti-inflammatory powers, ginger is especially helpful for managing chemo-induced nausea and digestive discomfort. * Green Tea (EGCG) – The antioxidant epigallocatechin gallate (EGCG) in green tea has shown promise in slowing the growth of certain cancer cells in lab studies. * Garlic – Packed with allicin, garlic may help boost immunity and has shown anticancer activity in both animal and population studies. * Ashwagandha – This adaptogenic herb may help the body manage stress and is being researched for its potential to limit cancer cell growth. * Milk Thistle – Traditionally used for liver support, milk thistle may help protect the liver during chemotherapy and reduce oxidative stress.   Again, none of these are cures, but they might support the body’s healing process when used wisely.   FREQUENTLY ASKED QUESTIONS (FAQS)   Q. 1) Is curcumin an anticancer agent?   Curcumin, the active compound in turmeric, has demonstrated anticancer properties in laboratory studies by inhibiting cancer cell proliferation and inducing apoptosis (programmed cell death). It affects various biological pathways involved in cancer development. However, clinical trials have shown limited effectiveness, partly due to curcumin's low bioavailability in the human body.     Q. 2) What are the benefits of turmeric and curcumin?   Turmeric and its primary component, curcumin, offer several health benefits. They possess potent anti-inflammatory and antioxidant properties, which may help reduce joint pain in osteoarthritis and support heart health. Additionally, curcumin has been explored for its potential to improve mood disorders and cognitive function. However, more extensive human studies are needed to confirm these effects.     Q. 3) Which vitamin is known as an anti-cancer vitamin?   Vitamin D has been studied for its potential role in cancer prevention. Some research suggests [https://www.health.harvard.edu/staying-healthy/vitamin-d-supplements-linked-to-lower-risk-of-advanced-cancer] a link between low levels of vitamin D and an increased risk of certain cancers. However, the evidence is not conclusive, and health professionals do not currently recommend vitamin D supplements specifically for cancer prevention.     Q. 4) How much curcumin is in 1 kg of turmeric?   Turmeric powder contains approximately 3% curcumin by weight. This means that 1 kilogram of turmeric powder would contain about 30 grams of curcumin. The exact curcumin content can vary depending on factors such as the turmeric variety and growing conditions.   FINAL THOUGHTS   Turmeric and curcumin aren’t miracle cures, but they’re seriously promising sidekicks. They’ve been used for centuries, and now science is finally catching up. Whether it’s reducing inflammation, helping treatments work better, or supporting your body’s own defenses, curcumin deserves a spot at the table (literally and figuratively).    Adding turmeric to your meals is generally safe and can even be tasty. But remember, it should complement, not replace, medical treatment. Always talk to your healthcare provider before making changes to your cancer care because real healing comes from a full plan, not a single spice.   READ ALSO   * Herbal Remedies for Lung Cancer [https://www.mrmed.in/health-library/cancer-care/herbal-remedies-lung-cancer-benefits] * High-Protein Foods for a Cancer Patient [https://www.mrmed.in/health-library/cancer-care/high-protein-foods-for-cancer-patients] * Cancer Patient Diet During Chemotherapy [https://www.mrmed.in/health-library/cancer-care/diet-during-chemotherapy] * Nutrition Before, During, And After Cancer Treatment [https://www.mrmed.in/health-library/cancer-care/nutrition-cancer-diet]   REFERENCES   1. https://pmc.ncbi.nlm.nih.gov/articles/PMC9072734/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC9072734/] 2. https://pmc.ncbi.nlm.nih.gov/articles/PMC5630447/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC5630447/] 3. https://pmc.ncbi.nlm.nih.gov/articles/PMC11537944/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC11537944/] 4. https://www.mdpi.com/2076-3921/13/3/331 [https://www.mdpi.com/2076-3921/13/3/331] 5. https://pmc.ncbi.nlm.nih.gov/articles/PMC5563402/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC5563402/]  6. https://pubmed.ncbi.nlm.nih.gov/27290916/ [https://pubmed.ncbi.nlm.nih.gov/27290916/] 
Dr. Vijayalakshmi
High Cortisol Know the Signs of Cushing’s
10 Apr 2025
8 Mins
Cushing's syndrome: Everything you need to knowCushing's syndrome is a rare but serious condition caused by prolonged exposure to high levels of cortisol, a hormone produced by the adrenal glands. Cortisol plays an essential role in various bodily functions, including regulating metabolism, blood sugar levels [https://www.mrmed.in/health-library/health-care/know-your-blood-sugar-numbers], and the body's response to stress. However, when cortisol levels are abnormally high for extended periods, it can lead to a range of symptoms and health complications.  The objective of this blog is to provide a comprehensive overview of Cushing's syndrome, including its causes, symptoms, and available treatment options, to help readers better understand and manage the condition effectively.   WHAT IS CUSHING'S SYNDROME?   Cushing’s syndrome, also known as Hypercortisolism, is a condition in which the body is exposed to elevated levels of cortisol over a prolonged period. Cortisol [https://www.mrmed.in/health-library/neurology/stress-cortisol-effects] is an essential hormone produced by the adrenal glands, playing a key role in the body’s stress response, metabolism, and immune function [https://www.mrmed.in/health-library/health-care/top-10-ways-to-improve-immune-system].    However, when cortisol levels become excessively high, it can lead to a variety of physical changes, such as weight gain, muscle weakness, high blood pressure [https://www.mrmed.in/health-library/hypertension/high-blood-pressure-symptoms], and more.   The Cushing syndrome definition refers to a set of symptoms resulting from chronic exposure to excess cortisol. In contrast, Cushing's disease is a specific type of Cushing's syndrome caused by a tumour in the pituitary gland that stimulates the adrenal glands to produce too much cortisol.   Understanding Cushing's syndrome physiology is crucial in comprehending the impact of high cortisol levels on the body. Cortisol affects many systems, including the metabolism of fats, proteins, and carbohydrates, leading to the development of common symptoms like abdominal fat accumulation, thinning skin, and increased susceptibility to infections.   A 2024 study [https://www.ncbi.nlm.nih.gov/books/NBK279088/] found that Cushing's disease, the most common cause of endogenous Cushing's syndrome, accounts for 60-80% of cases. The incidence is estimated to be between 0.7 and 2.4 per million per year, with a higher prevalence in women aged 25 to 40.   WHAT IS THE DIFFERENCE BETWEEN CUSHING SYNDROME VS CUSHING’S DISEASE?   It’s important to distinguish between Cushing's syndrome and Cushing's disease. While both conditions involve excessive cortisol, Cushing’s disease is a more specific diagnosis, where the underlying cause is a pituitary adenoma (a benign tumour of the pituitary gland).    In contrast, Cushing's syndrome can be caused by other factors, such as long-term use of corticosteroid medications or tumours in the adrenal glands.   Dr. Pranav A Ghody [https://www.wockhardthospitals.com/doctor/dr-pranav-ghody/], Endocrinologist, Wockhardt Hospital, Mumbai Central said, “Cortisol has effects on almost every organ in our body; it is essential for maintaining blood pressure, blood sugar, energy metabolism and inflammation control. This hormone is often called the stress hormone as the adrenal glands produce more cortisol to regulate the stress response. Excessive cortisol levels over a period cause a complex disorder called Cushing’s syndrome”   WHAT ARE THE CAUSES OF CUSHING'S SYNDROME?   Several factors can lead to the development of Cushing’s syndrome, ranging from medication use to more complex physiological issues. Some of the common Cushing syndrome causes include:   * Corticosteroid Medications: Long-term use of oral or injected steroids, such as prednisone, is one of the most common causes of Cushing's syndrome. These medications mimic cortisol in the body and, when used over time, can lead to hypercortisolism.   * Pituitary tumours (Cushing’s Disease): A benign tumour in the pituitary gland can lead to the overproduction of adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to produce excessive cortisol. This is referred to as Cushing’s disease.   * Adrenal tumours: Tumours in the adrenal glands can also cause overproduction of cortisol, leading to hypercortisolism.   * Ectopic ACTH Syndrome: In rare cases, tumours in other parts of the body (such as the lungs) may produce ACTH, triggering excessive cortisol production.   * Genetic Factors: Some rare genetic conditions can predispose individuals to developing Cushing's syndrome or other related disorders.   WHAT ARE THE SIGNS AND SYMPTOMS OF CUSHING'S SYNDROME?   The symptoms of Cushing's syndrome vary from person to person but generally result from prolonged exposure to high cortisol levels. Common Cushing syndrome symptoms include:   * Weight Gain: One of the hallmark symptoms of Cushing syndrome is the accumulation of fat around the face, upper back, and abdomen, leading to a characteristic "moon face" and "buffalo hump."   * Skin Changes: Individuals with Cushing's syndrome may experience thinning of the skin, easy bruising, and the development of purple or pink stretch marks (striae), especially on the abdomen, thighs, and arms.   * Muscle Weakness: The excess cortisol leads to muscle breakdown, causing weakness, particularly in the arms and legs.   * High Blood Pressure: Cortisol can increase blood pressure, and many individuals with Cushing's syndrome also have hypertension.   * Mood Changes: Elevated cortisol levels can cause mood swings, irritability, anxiety, and even depression.   * Irregular Menstrual Cycles: Women with Cushing's syndrome may experience irregular periods or even amenorrhea (absence of menstruation).   * Fatigue: Chronic fatigue and a general feeling of being unwell are common among those suffering from Cushing's syndrome.   In more severe cases, Cushing's syndrome can lead to diabetes, osteoporosis, and even an increased risk of infections.   WHAT ARE THE DIAGNOSIS FOR CUSHING'S SYNDROME?   Cushing's Syndrome Diagnosis can be challenging due to the wide variety of symptoms that overlap with other medical conditions. A doctor may start by performing several tests, including:   * 24-Hour Urinary Free Cortisol Test: This test measures the amount of cortisol excreted in the urine over a 24-hour period.   * Blood and Saliva Tests: These tests measure cortisol levels at various times of the day. Normally, cortisol levels should be lower in the evening than in the morning.   * Dexamethasone Suppression Test: This test involves taking a dose of dexamethasone [https://www.mrmed.in/molecule/dexamethasone] (a synthetic steroid) and measuring cortisol levels afterward. In people with Cushing's syndrome, the cortisol levels typically do not decrease as they would in a healthy individual.   * Imaging Tests: CT scans or MRIs may be used to detect tumours in the pituitary or adrenal glands.   WHAT ARE THE BEST TREATMENTS FOR CUSHING'S SYNDROME?   Treatment for Cushing's syndrome depends on the underlying cause of the condition. Cushing's syndrome treatment options include the following:   1. Surgical Removal of tumours: If a tumour is responsible for excessive cortisol production, surgical removal is often the first line of treatment.   2. Radiation Therapy: For pituitary tumours that cannot be removed surgically, radiation therapy [https://www.mrmed.in/health-library/cancer-care/cancer-treatment-using-radiation-therapy] may be recommended.   3. Medications: In some cases, medications may be prescribed to block cortisol production or its effects on the body. These include drugs like ketoconazole [https://www.mrmed.in/molecule/ketoconazole], metyrapone, or mitotane.   4. Corticosteroid Reduction: If Cushing syndrome is caused by long-term use of corticosteroid medications, the doctor may gradually taper off the steroids, but only under careful medical supervision.   5. Lifestyle and Diet Changes: A Cushing syndrome diet that focuses on managing weight, controlling blood pressure, and reducing the risk of diabetes [https://www.mrmed.in/health-library/diabetes/common-side-effects-of-diabetes] can be essential for recovery. A healthy diet and regular exercise can help manage many symptoms.   WHAT FOODS ARE GOOD FOR CUSHING'S SYNDROME?   A balanced Cushing's syndrome diet can significantly help manage symptoms by regulating cortisol levels, blood pressure, and weight. Whether dealing with mild Cushing's syndrome or the more severe form, proper nutrition is essential for recovery.    Below is a sample diet chart for Cushing's syndrome, featuring Indian foods that can aid in managing this condition. Here’s a sample diet chart for Cushing’s syndrome:   Time Food to prefer Reason Early MorningWarm water with lemon and a pinch of turmericHelps detoxify the body and reduce inflammation.BreakfastOats porridge with chia seeds, nuts (almonds, walnuts), and fresh fruits (like apple or papaya)High in fiber, antioxidants, and healthy fats, which are good for weight management and metabolism.Mid-Morning SnackFresh coconut water and a small bowl of mixed fruits (like berries, pomegranate)Hydrates and replenishes electrolytes.LunchBrown rice with dal (lentils), vegetable curry (like spinach, cauliflower, and carrots), and roti (whole wheat)Protein-rich dal supports muscle health, and veggies provide essential vitamins.Afternoon SnackButtermilk (chaas) with roasted flax seedsGood for digestion and provides probiotics.Evening SnackBaked or roasted chickpeas (chana) or a small serving of mixed nutsHigh in protein and fibre and supports blood sugar control and muscle recovery.DinnerGrilled or steamed fish (like mackerel or tilapia) or tofu with steamed vegetables (like broccoli or zucchini)Lean protein helps in muscle repair and stabilises cortisol levels.Post-DinnerA warm cup of herbal tea (like chamomile or peppermint)Helps reduce stress and promotes better sleep.   WHAT FOODS SHOULD CUSHING PATIENTS AVOID?   * High-Sodium Foods: Processed foods, canned foods, and salty snacks can exacerbate high blood pressure.   * Refined Sugars: Sweets, sugary beverages, and pastries can lead to blood sugar spikes, worsening the condition.   * Excessive Caffeine: Limit coffee or caffeinated beverages, as they can increase cortisol production.   CUSHING SYNDROME BEFORE AND AFTER DIETARY CHANGES   Before adopting a healthier diet, individuals with Cushing's syndrome may experience significant weight gain, fatigue, and high blood pressure. After following a well-structured Cushing syndrome diet, including more whole foods, lean proteins, and fiber-rich vegetables, many people notice improvements in weight management, reduced bloating, and a reduction in blood pressure.   FREQUENTLY ASKED QUESTIONS    Q1. What is the difference between Cushing syndrome vs Addison's disease?   Cushing's syndrome is caused by high levels of cortisol in the body, often due to overproduction or steroid use, leading to symptoms like weight gain and high blood pressure. In contrast, Addison's disease results from insufficient cortisol production, causing symptoms like fatigue, weight loss, and low blood pressure.   Q2. What is the difference between Primary vs secondary hypercortisolism?   Primary hypercortisolism, also known as Cushing's disease, occurs when the adrenal glands produce excess cortisol, usually due to a tumour. Secondary hypercortisolism is caused by excessive production of ACTH (adrenocorticotropic hormone) from the pituitary gland, which stimulates the adrenal glands to produce more cortisol.   Q3. What are the three symptoms of Cushing's syndrome?   Three symptoms of Cushing's syndrome include weight gain, particularly around the abdomen and face (moon face), high blood pressure, and muscle weakness.   Q4. Can corticosteroids cause Cushing's syndrome?   Yes, corticosteroids can cause Cushing's syndrome when taken in high doses or for extended periods, leading to increased cortisol levels in the body.   Q5. Are you born with Cushing's syndrome?   Cushing's syndrome is typically not something you're born with; it usually develops due to factors like tumours or prolonged steroid use. However, some rare genetic conditions can cause it. Hypercortisolemia vs hypercortisolism refers to the same condition—both terms describe the excessive presence of cortisol in the body, but hypercortisolemia is a broader term that may encompass other causes beyond Cushing's syndrome.   WRAPPING UP   Cushing syndrome is an endocrine disorder caused by prolonged high cortisol levels resulting from factors like medication use or pituitary tumours. Early symptom recognition, accurate diagnosis, and appropriate treatment are crucial for effective management.    If you suspect Cushing's syndrome, consult a healthcare provider to explore causes and treatment options, helping you manage the condition and improve your quality of life.   ALSO, READ OUR OTHER RELATED ARTICLES:   1. Top 10 Triggers of Mental Stress You Can’t Ignore [https://www.mrmed.in/health-library/mental-wellness/mental-stress-causes] 2. What’s Really Weakening Your Immune System? [https://www.mrmed.in/health-library/health-care/weak-immune-system]   REFERENCES    1. Chaudhry HS, Singh G. Cushing Syndrome. [Updated 2023 Jun 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470218/ [https://www.ncbi.nlm.nih.gov/books/NBK470218/] 2. Lodish MB, Keil MF, Stratakis CA. Cushing's Syndrome in Pediatrics: An Update. Endocrinol Metab Clin North Am. https://pubmed.ncbi.nlm.nih.gov/29754644/ [https://pubmed.ncbi.nlm.nih.gov/29754644/] 3. Osswald A, Deutschbein T, Berr CM, Plomer E, Mickisch A, Ritzel K, Schopohl J, Beuschlein F, Fassnacht M, Hahner S, Reincke M. Surviving ectopic Cushing's syndrome: quality of life, cardiovascular and metabolic outcomes in comparison to Cushing's disease during long-term follow-up. Eur J Endocrinol. https://pubmed.ncbi.nlm.nih.gov/29875286/ [https://pubmed.ncbi.nlm.nih.gov/29875286/]
Dr. Vijayalakshmi